Extracellular measurements of averaged ionic currents with the light-addressable potentiometric sensor (LAPS)

Stein, Bernhard

doi:10.1016/j.snb.2003.10.034

Cited by 75 publications

(32 citation statements)

References 50 publications

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“…As established in many studies, LAPSs can be used to build cell-semiconductor compound systems for monitoring extracellular electric potentials. (51,52) Xu et al (53) used LAPSs to monitor single excitable cell membrane electric potentials without damage. LAPS technology has many advantages.…”

Section: Biomimetic Olfactory Sensors Based On Light Addressable Potementioning

confidence: 99%

Recent Advances in Olfactory Receptor (OR) Biosensors and Cell Signaling Cascade Amplification Systems

2018

Sensors and Materials

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There are a variety of methods to detect odorant molecules, including gas chromatography (GC) and its related coupled techniques, electronic noses, and olfactory receptor (OR)-based biosensors. Nevertheless, studies in which cell and cell signaling amplifier systems were directly utilizied to detect odors are very few. In this review, we aim to provide some references and suggestions for researchers in related fields by summarizing OR sensors and olfactory cell signaling cascade amplifier systems. In this paper, we summarize the detection methods for odorants, introduce the research and progress on OR sensors, and present a proposal of utilizing cell or tissue signaling cascade amplifier systems to amplify electrochemical signals and the use of the G protein signaling cascade amplifier system to prepare electrochemical biosensors. In recent years, the detection technology of electrochemical sensors has matured. Meanwhile, olfactory sensation within organisms basically transfer nerve signals or metabolic endocrine signals in the form of electrochemical signals. Therefore, ORs combined with cell signaling cascade amplifier systems, as well as electrochemical sensors of signal cascade amplifier systems, have incredible prospects for development and application. The proposal of OR electrochemical biosensors and their cell signaling cascade amplifier systems, provides a new idea and a quantitative method for the detection and assessment of odorants and their physiologic processes in the nervous system.

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Section: Biomimetic Olfactory Sensors Based On Light Addressable Potementioning

confidence: 99%

Recent Advances in Olfactory Receptor (OR) Biosensors and Cell Signaling Cascade Amplification Systems

2018

Sensors and Materials

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show abstract

“…Lots of experiments have been done that investigate on LAPS as a possible cell-semiconductor hybrid system to monitor the extracellular potentials of the cells [21,22]. Based on basic detection theories of the extracellular potential, olfactory neurons can be cultivated on the surface of LAPS to monitor their potentials ( Fig.…”

Section: Theories Of Cell Electrophysiological Recordingmentioning

confidence: 99%

Olfactory Cell-Based Smell Sensors

Liu

2015

Bioinspired Smell and Taste Sensors

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“…Table 1 lists pioneering works and currently active groups or companies that have developed or commercialized key MEA technologies. Light-addressable devices were omitted (Bucher et al, 2001;Stein et al, 2004;Starovoytov et al, 2005;Suzurikawa et al, 2006). The terminology 'passive devices' refers to substrates with microelectrodes, tracks and connection pads that need to be connected to external amplification and signal processing hardware.…”

Section: In Vitro Microelectrode Arraysmentioning

confidence: 99%

Prospects for Neuroprosthetics: Flexible Microelectrode Arrays with Polymer Conductors

Blau¹

2011

Applied Biomedical Engineering

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Extracellular measurements of averaged ionic currents with the light-addressable potentiometric sensor (LAPS)

Cited by 75 publications

References 50 publications

Recent Advances in Olfactory Receptor (OR) Biosensors and Cell Signaling Cascade Amplification Systems

Recent Advances in Olfactory Receptor (OR) Biosensors and Cell Signaling Cascade Amplification Systems

Olfactory Cell-Based Smell Sensors

Prospects for Neuroprosthetics: Flexible Microelectrode Arrays with Polymer Conductors

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