Extracellular micronutrient levels and pro-/antioxidant status in trauma patients with wound healing disorders: results of a cross-sectional study

Blaß, Sandra; Goost, H.; Burger, C.; Tolba, René; Stoffel‐Wagner, Birgit; Stehle, Peter; Ellinger, Sabine

doi:10.1186/1475-2891-12-157

Cited by 26 publications

(9 citation statements)

References 29 publications

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“…Trauma patients with skin wound healing disorder present with reduced serum selenium status. Therefore, lower selenium restricts the abundance of GPX2 protein; providing patients with selenium supplementation helps to improve GPX2 protein level (Blass et al 2013). Appropriate mechanism responsible for this needs to be further experimented.…”

Section: Role Of Glutathione Peroxidases-a Type Of Selenoprotein In Wmentioning

confidence: 99%

Selenium and selenoproteins: it’s role in regulation of inflammation

2020

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Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.

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Section: Role Of Glutathione Peroxidases-a Type Of Selenoprotein In Wmentioning

confidence: 99%

Selenium and selenoproteins: it’s role in regulation of inflammation

2020

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“…Prealbumin has been suggested to be a more suitable biochemical marker for monitoring nutritional status, due to its short half-life of two days and its sensitivity to changes in protein-energy status within four to eight days, in both the presence and absence of inflammation [ 27 , 28 ]. Prealbumin reflects more recent protein intake as opposed to albumin, which reflects long-term protein supply [ 29 , 30 ]. The current study investigated the use of prealbumin as a marker of nutritional status compared to albumin in adults singly or dually infected with HIV and intestinal helminth parasites with or without inflammatory conditions as indicated by C-reactive protein (CRP) in different BMI categories in an adult population in KwaZulu-Natal, South Africa.…”

Section: Introductionmentioning

confidence: 99%

The Investigation of the Use of Prealbumin as a Tool for Nutritional Assessment in Adults Coinfected with HIV and Intestinal Helminth Parasites in KwaZulu-Natal, South Africa

Mkhize

Mabaso

Madurai³

et al. 2018

BioMed Research International

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Serum prealbumin is considered to be as important as albumin in the nutritional status assessment. However, there is relatively little evidence of its advantage over the commonly used albumin. This study investigated the use of prealbumin compared to albumin as a marker of nutritional status in adults singly and dually infected with human immunodeficiency virus (HIV) and intestinal helminths, with or without inflammatory conditions, in different body mass index (BMI) categories. This cross-sectional study was conducted in a periurban setting in KwaZulu-Natal, South Africa. Multivariate multinomial logistic regression models were fitted to investigate the effect of prealbumin and albumin in nutritional assessment among HIV and helminth individuals with or without inflammation, indicated by elevated and normal C-reactive protein (CRP) levels. In normal CRP, albumin was significantly lower in unadjusted BMI [RRR = 0.8, p = 0.001] and in normal weight [RRR = 0.7, p = 0.003] and overweight [RRR = 0.5, p = 0.001] participants. In elevated CRP, albumin was significantly lower [RRR = 0.8, p = 0.050] and prealbumin was significantly higher in unadjusted BMI [RRR = 1.2, p = 0.034] and overweight [RRR = 1.4, p = 0.052] individuals. The current study found that prealbumin can differentiate between inflammation-induced reduction of albumin and true malnutrition in adults singly or coinfected with HIV and intestinal helminths in the presence or absence of inflammation in various BMI categories.

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“…Notably, the availability of selenium restricts the abundance of the GPX1 protein. Almost a quarter of trauma patients with skin wound healing disorders show an insufficient serum selenium status [56], suggesting the possible involvement of GPX in the pathogenesis. Selenium supplementation to macrophages in vitro can switch macrophages from M1, which generates ROS, to M2, which promotes cell proliferation [57].…”

Section: Glutathione Peroxidase (Gpx)mentioning

confidence: 99%

Roles of Antioxidative Enzymes in Wound Healing

Kurahashi

Fujii

2015

JDB

187

114

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Abstract:Since skin is the first barrier separating the body from the external environment, impaired wound healing can be life threatening to living organisms. Delayed healing processes are observed in animals under certain circumstances, such as advanced age, diabetes, and immunosuppression, but the underlying mechanisms of the abnormality remain elusive. Redox homeostasis is defined as the balance between the levels of reactive oxygen species (ROS) and antioxidants in which antioxidative enzymes play central roles in scavenging ROS. In addition to deleterious effects, ROS also exert beneficial functions on some cellular processes such as transducing phosphorylation signaling, but excessive antioxidants may impede the healing process. Hence, strict control over the amounts of antioxidants is desirable when applied for therapeutic purposes. Here we overview recent findings regarding the relationships between antioxidative enzymes and wound healing. Unveiling the role of antioxidative enzymes is expected to contribute to our understanding of the wound healing processes.

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Extracellular micronutrient levels and pro-/antioxidant status in trauma patients with wound healing disorders: results of a cross-sectional study

Cited by 26 publications

References 29 publications

Selenium and selenoproteins: it’s role in regulation of inflammation

Selenium and selenoproteins: it’s role in regulation of inflammation

The Investigation of the Use of Prealbumin as a Tool for Nutritional Assessment in Adults Coinfected with HIV and Intestinal Helminth Parasites in KwaZulu-Natal, South Africa

Roles of Antioxidative Enzymes in Wound Healing

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