Extracellular protection of the vascular wall with the covalently connected antioxidant enzymes against oxidative damage

Neoglycoenzymes

“…To prepare a more potent antithrombotic adduct, these authors developed an original approach based on the bienzymatic cross-linking of SOD and catalase with chondroitin sulfate. The bienzymatic neoglycoconjugate showed a noticeable antithrombotic activity, being effective at doses 2 orders of magnitude smaller than those for native SOD and catalase, and an order of magnitude smaller than that for the chondroitin sulfate-modified enzymes, administered either individually or as a mixture. ,, …”