Extracellular superoxide produced by <i>Enterococcus faecalis</i> reduces endometrial receptivity via inflammatory injury

Zhang, Zhanhu; Li, Tianqi; Xu, Lili; Wang, Qiuhong; Li, Haibo; Wang, Xingmin

doi:10.1111/aji.13453

Cited by 7 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Superoxide-producing E. faecalis OG1RF infection of endometrial epithelial cells causes the production of inflammatory cytokines, encourages apoptosis, and suppresses the expression of receptivity indicators. Extracellular superoxide is a virulence factor of E. faecalis -induced endometritis that might result in decreased receptivity of endometrial epithelial cells and potentially lead to infertility [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Didziokaite

Biliute

Gudaite

et al. 2023

IJMS

View full text Add to dashboard Cite

Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometriosis development. While the link between endometriosis and infertility is well established, minimal or mild stages of endometriosis are not considered to cause infertility. Increasing evidence of OS as a leading agent in the development of endometriosis has brought up a theory of minimal/mild endometriosis itself being one of the manifestations of high OS rather than a separate disease which directly causes infertility. Moreover, further development of the disease is thought to contribute to an increased production of reactive oxygen species (ROS) thus leading to the progression of endometriosis itself as well as to other pathological processes in the female reproductive system. Therefore, in case of minimal or mild endometriosis, the less invasive treatment could be offered in order to stop the ongoing cycle of endometriosis-reinforced excess ROS production and to reduce their harmful effects. In this article the existing connection between OS, endometriosis, and infertility is explored.

show abstract

Section: Discussionmentioning

confidence: 99%

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Didziokaite

Biliute

Gudaite

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Enterococcus spp. are rare to find in the uterus of healthy mares; however, E. faecalis has been isolated from mares with chronic endometritis and infertility [ 67 ]. Acinetobacter baumannii has been found in the uterus of healthy mares, and in equine patients with wounds, septicemia, eye infections, bronchopneumonia, neonatal encephalopathy, and venous catheter [ 36 , 37 , 68 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance and Extended-Spectrum Beta-Lactamase Genes in Enterobacterales, Pseudomonas and Acinetobacter Isolates from the Uterus of Healthy Mares

Thomson,

García,

Río

et al. 2023

Pathogens

View full text Add to dashboard Cite

Antibiotic-resistant bacteria are a growing concern for human and animal health. The objective of this study was to determine the antimicrobial resistance and extended-spectrum beta-lactamase genes in Enterobacterales, Pseudomonas spp. and Acinetobacter spp. isolates from the uterus of healthy mares. For this purpose, 21 mares were swabbed for samples, which were later seeded on blood agar and MacConkey agar. The isolates were identified using MALDI-TOF and the antimicrobial susceptibility test was performed using the Kirby–Bauer technique. To characterize the resistance genes, a polymerase chain reaction (PCR) scheme was performed. Of the isolates identified as Gram-negative, 68.8% were Enterobacterales, represented by E. coli, Enterobacter cloacae, Citrobacter spp., and Klebsiella pneumoniae; 28.1% belonged to the genus Acinetobacter spp.; and 3.1% to Pseudomonas aeruginosa. A 9.3% of the isolates were multidrug-resistant (MDR), presenting resistance to antibiotics from three different classes, while 18.8% presented resistance to two or more classes of different antibiotics. The diversity of three genes that code for ESBL (blaTEM, blaCTX-M and blaSHV) was detected in 12.5% of the strains. The most frequent was blaSHV, while blaTEM and blaCTX-M were present in Citrobacter spp. and Klebsiella pneumoniae. These results are an alarm call for veterinarians and their environment and suggest taking measures to prevent the spread of these microorganisms.

show abstract

Endometrial preparation protocols did not impact pregnancy outcomes of patients with cured chronic endometritis

Zhang,

Qiu,

Liu

et al. 2024

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Extracellular superoxide produced by Enterococcus faecalis reduces endometrial receptivity via inflammatory injury

Cited by 7 publications

References 24 publications

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Antimicrobial Resistance and Extended-Spectrum Beta-Lactamase Genes in Enterobacterales, Pseudomonas and Acinetobacter Isolates from the Uterus of Healthy Mares

Endometrial preparation protocols did not impact pregnancy outcomes of patients with cured chronic endometritis

Contact Info

Product

Resources

About