Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Hoshino, Ayuko; Kim, Han Sang; Bojmar, Linda; Gyan, Kofi K.; Cioffi, Michèle; Hernandez, Jonathan M.; Zambirinis, Constantinos P.; Rodrigues, Gonçalo; Molina, Henrik; Heissel, Søren; Mark, Milica Tešić; Steiner, Loïc; Benito-Martín, Alberto; Lucotti, Serena; Giannatale, Angela Di; Offer, Katharine; Nakajima, Miho; Williams, Caitlin; Nogués, Laura; Vatter, Fanny A. Pelissier; Hashimoto, Ayako; Davies, Alexander E.; Freitas, Daniela; Kenific, Candia M.; Ararso, Yonathan; Buehring, Weston; Lauritzen, Pernille; Ogitani, Yusuke; Sugiura, Kei; Takahashi, Naoko; Alečković, Maša; Bailey, Kayleen; Jolissant, Joshua S.; Wang, Huajuan; Harris, Ashton; Schaeffer, Laurent; García-Santos, Guillermo; Posner, Zoe; Balachandran, Vinod P.; Khakoo, Yasmin; Raju, G. Praveen; Scherz, Avigdor; Sagi, Irit; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Malladi, Mahathi; Petriccione, Mary; Braganca, Kevin C. De; Donzelli, Maria; Fischer, Cheryl; Vitolano, Stephanie; Wright, Geraldine P.; Ganshaw, Lee; Marrano, Mariel; Ahmed, Amina; DeStefano, Joe; Danzer, Enrico; Roehrl, Michael H. A.; Lacayo, Norman J.; Vincent, C. Theresa; Weiser, Martin R.; Brady, Mary S.; Meyers, Paul A.; Wexler, Leonard H.; Ambati, Srikanth R.; Chou, Alexander J.; Slotkin, Emily K.; Modak, Shakeel; Roberts, Stephen S.; Basu, Ellen M.; Diolaiti, Daniel; Krantz, Benjamin A.; Cardoso, Fátima; Simpson, Amber L.; Berger, Michael F.; Rudin, Charles M.; Simeone, Diane M.; Jain, Maneesh; Ghajar, Cyrus M.; Batra, Surinder K.; Stanger, Ben Z.; Bui, Jack D.; Brown, Kristy A.; Rajasekhar, Vinagolu K.; Healey, John H.; Sousa, Maria de; Krämer, Kim; Sheth, Sujit; Baisch, Jeanine; Pascual, Virginia; Heaton, Todd E.; Quaglia, Michael P. La; Pisapia, David; Schwartz, Robert E.; Zhang, Haiying; Liu, Yuan; Shukla, Arti; Blavier, Laurence; DeClerck, Yves A.; LaBarge, Mark A.; Bissell, Mina J.; Caffrey, Thomas C.; Grandgenett, Paul M.; Hollingsworth, Michael A.; Bromberg, Jacqueline; Costa-Silva, Bruno; Peinado, Héctor; Kang, Yibin; García, Benjamin A.; O'Reilly, Eileen Mary; Kelsen, David P.; Trippett, Tanya M.; Jones, David R.; Matei, Irina; Jarnagin, William R.; Lyden, David

doi:10.1016/j.cell.2020.07.009

Cited by 858 publications

(717 citation statements)

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“…More recently, the composition of EVs has been extensively reassessed, and some previous findings have been overturned. [ 248,249 ] In future, it will be necessary to interrogate EV composition at the single‐vesicle level and also to dissect EV biogenesis at the single‐cell level in order to provide a basis for proper design and engineering of EVs for therapeutic applications.…”

Section: Discussionmentioning

confidence: 99%

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

2020

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Extracellular vesicles (EVs) are biocompatible, nano-sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next-generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.

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Section: Discussionmentioning

confidence: 99%

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

2020

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“…Future investigation will enable the identification of which EV biomolecules mediate the transcription reprogramming here described. In addition, based on previous works that utilized plasma EVs as biomarkers for diagnosis, prognosis, and follow-up of cancer patients (Peinado et al, 2012;Costa-Silva et al, 2015;Hoshino et al, 2015Hoshino et al, , 2020Melo et al, 2015), it is possible that EV biomolecules linked with PC-CD11b + BM cell communication may enable early detection of this process through the study of circulating plasma EVs. We will here discuss on genes regulated by PC-EVs with potential relevance to tumor microenvironments and the biology of monocytes/macrophages.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles

Maia

Otake

Poças

et al. 2020

Front. Cell Dev. Biol.

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Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and expression of inflammatory molecules. Together, these results show for the first time the existence of a PC–BM communication axis mediated by EVs with a potential role in PC tumor microenvironments.

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“…More recently, there has been a growing interest in EVs as biomarkers for viral-associated CLD and HCC. An EV-based liquid biopsy is useful because EVs from diseased individuals often carry specific proteins, nucleic acids, and metabolites that can reveal the status of disease (Whiteside, 2017;Hoshino et al, 2020). Unlike standard liver biopsy, liquid biopsy is non-invasive and less costly to perform.…”

Section: The Role Of Extracellular Vesicles As a Biomarker For Virus-mentioning

confidence: 99%