Extracellular Vesicle lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Released From Glioma Stem Cells Modulates the Inflammatory Response of Microglia After Lipopolysaccharide Stimulation Through Regulating miR-129-5p/High Mobility Group Box-1 Protein Axis

Yang, Jian; Sun, Guibo; Hu, Yuhua; Yang, Jianhui; Shi, Yijun; Liu, Hongjiang; Li, Chen; Lv, Zhongqiang; Niu, Jianxing; Liu, Honglei; Shi, Xianglin; Wang, Haiping; Li, Pan; Jiao, Baohua

doi:10.3389/fimmu.2019.03161

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…The miR-129-5p/HMGB1 axis is widely involved in biological processes such as inflammation, cell proliferation and autophagy, and affects the progression of several diseases including chronic constriction injuries, cerebral hemorrhage and lung cancer. 8,17–21…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury

2021

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Objectives To investigate the mechanisms underlying the protective effect of sufentanil against acute lung injury (ALI). Material and Methods Rats were administered lipopolysaccharide (LPS) by endotracheal instillation to establish a model of ALI. LPS was used to stimulate BEAS-2B cells. The targets and promoter activities of IκB were assessed using a luciferase reporter assay. Apoptosis of BEAS-2B cells was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling. Results Sufentanil treatment markedly reduced pathological changes in lung tissue, pulmonary edema and secretion of inflammatory factors associated with ALI in vivo and in vitro. In addition, sufentanil suppressed apoptosis induced by LPS and activated NF-κB both in vivo and in vitro. Furthermore, upregulation of high mobility group box protein 1 (HMGB1) protein levels and downregulation of miR-129-5p levels were observed in vivo and in vitro following sufentanil treatment. miR-129-5p targeted the 3ʹ untranslated region and its inhibition decreased promoter activities of IκB-α. miR-129-5p inhibition significantly weakened the protective effect of sufentanil on LPS-treated BEAS-2B cells. Conclusion Sufentanil regulated the miR-129-5p/HMGB1 axis to enhance IκB-α expression, suggesting that sufentanil represents a candidate drug for ALI protection and providing avenues for clinical treatment.

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury

2021

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“… 194 Studies have shown that glioblastomas are infiltrated with a large number of microglial cells, which interact with glioblastomas and induce tumor immunosuppression. 195 Recently, a study performed by Yang and his colleagues demonstrated that EVs lncRNA MALAT1 released from GSCs mediated LPS-induced inflammatory response of microglia by targeting miR-129-5p/HMGB1 (high mobility group box-1) protein alix. 195 When co-incubating with GSCs-derived EVs, IL-6, IL-8, and TNF-α secreted by LPS-stimulated microglial increased significantly.…”

Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 99%

The key roles of cancer stem cell-derived extracellular vesicles

Zhang

Yarden

et al. 2021

Sig Transduct Target Ther

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Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metastasis. Extracellular vesicles (EVs) are nano-sized particles released by different kinds of cells and have the capacity to deliver certain cargoes, such as nucleic acids, proteins, and lipids, which have been recognized as a vital mediator in cell-to-cell communication. Recently, more and more studies have reported that EVs shed by CSCs make a significant contribution to tumor progression. CSCs-derived EVs are involved in tumor resistance, metastasis, angiogenesis, as well as the maintenance of stemness phenotype and tumor immunosuppression microenvironment. Here, we summarized the molecular mechanism by which CSCs-derived EVs in tumor progression. We believed that the fully understanding of the roles of CSCs-derived EVs in tumor development will definitely provide new ideas for CSCs-based therapeutic strategies.

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“…Decidual natural killer cells (dNKs) account for approximately 70% of the immune cells at the maternal–fetal interface, comprise the largest specific immune cell population and decrease with increasing gestational age 8 . dNK cells are distinct from the majority of peripheral blood NK cells (pNKs).…”

Section: Introductionmentioning

confidence: 99%

“…dNK cells are distinct from the majority of peripheral blood NK cells (pNKs). Approximately 90% of pNKs have a CD56 dim CD16 + surface phenotype that represents cytotoxic NK cells 8 , but almost all dNKs are CD56 + CD16 – 9 , representing cytokine-producing NK cells. The presence of dNKs in early pregnancy can help the decidualization of the endometrium and the invasion of trophoblasts 9 .…”

Section: Introductionmentioning

confidence: 99%

The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells

Jiang

Shen

Zhou

et al. 2021

Sci Rep

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Despite the advances made in the management of pregnancies in women with systemic lupus erythematosus (SLE), the rate of adverse pregnancy outcomes is still higher than that in the general population. In the last few years, neutrophil extracellular traps (NETs) were proven to be detrimental in both autoimmune diseases and placental injury. We investigated whether NETs could be detected in the placentas of pregnant individuals with SLE and explored the relationship between NETs and decidual natural killer cells (dNKs), which comprise the majority of immune cells at the maternal–fetal interface, using clinical samples and animal models. In this study, we found that the infiltration of NETs and dNKs, especially CD56+CD16+ NK cells, was significantly increased in pregnant individuals with SLE with placental insufficiency. In the murine models of SLE, the number of dNKs was significantly decreased due to the decreased formation of NETs affected by Ly6G. Moreover, the histopathological placental injury was reduced, with a remarkable increase in fetal birth weight. This study shows that NETs may contribute to immunological disorder in the placenta and the pathological changes in pregnancies with SLE, which provides a research basis for further explorations of the mechanism of SLE in placental impairment.

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Extracellular Vesicle lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Released From Glioma Stem Cells Modulates the Inflammatory Response of Microglia After Lipopolysaccharide Stimulation Through Regulating miR-129-5p/High Mobility Group Box-1 Protein Axis

Cited by 34 publications

References 27 publications

In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury

In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury

The key roles of cancer stem cell-derived extracellular vesicles

The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells

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