Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes

Wei, J L; Wang, Zhenghao; Han, Tingrui; Chen, Jiaoting; Ou, Yiran; Lan, Wei; Zhu, Xinyue; Wang, Ke; Yan, Zhe; Han, Yuan‐Ping; Zheng, Xiaofeng

doi:10.3389/fendo.2023.1170237

Cited by 7 publications

(4 citation statements)

References 158 publications

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“…Proteins and nucleic acids (miRNA, mRNA, and lncRNA) are abundant in content found in EVs. Due to their genetic material carrying capacity, EVs are crucial in various diseases ( 51 ).…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

Wang,

et al. 2024

Front. Immunol.

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Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper focuses on the regulatory role of tumor-derived EVs on macrophages. It aims to investigate the causes of tumor progression and therapeutic directions. Tumor-derived EVs can cause macrophages to shift to M1 or M2 phenotypes. This indicates they can alter the M1/M2 cell ratio and have pro-tumor and anti-inflammatory effects. This paper discusses several key points: first, the factors that stimulate macrophage polarization and the cytokines released as a result; second, an overview of EVs and the methods used to isolate them; third, how EVs from various cancer cell sources, such as hepatocellular carcinoma, colorectal carcinoma, lung carcinoma, breast carcinoma, and glioblastoma cell sources carcinoma, promote tumor development by inducing M2 polarization in macrophages; and fourth, how EVs from breast carcinoma, pancreatic carcinoma, lungs carcinoma, and glioblastoma cell sources carcinoma also contribute to tumor development by promoting M2 polarization in macrophages. Modified or sourced EVs from breast, pancreatic, and colorectal cancer can repolarize M2 to M1 macrophages. This exhibits anti-tumor activities and offers novel approaches for tumor treatment. Therefore, we discovered that macrophage polarization to either M1 or M2 phenotypes can regulate tumor development. This is based on the description of altering macrophage phenotypes by vesicle contents.

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“…Proteins and nucleic acids (miRNA, mRNA, and lncRNA) are abundant in content found in EVs. Due to their genetic material carrying capacity, EVs are crucial in various diseases ( 51 ).…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

Wang,

et al. 2024

Front. Immunol.

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“…Furthermore, emerging evidence suggests that extracellular vesicle (EVs)-mediated crosstalk between pancreatic islet cells and between organs is involved in the progression of diabetes. EVs derived from β-cells can also affect recipient β-cells and further exert negative effects through autocrine signaling in type 2 diabetes ( Wei et al, 2023 ).…”

Section: The Pathological Mechanisms In Elderly Diabetes Mellitusmentioning

confidence: 99%

Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application

Zhang,

Hu,

Jin

et al. 2024

Front. Pharmacol.

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Objective: Affected by aging, the elderly diabetes patients have many pathological characteristics different from the young people, including more complications, vascular aging, cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis and the mechanism of Traditional Chinese medicine (TCM) intervention, and use the method of systematic review to evaluate the clinical application of TCM in elderly diabetes.Method: Searching for randomized controlled trials (RCTs) published from January 2000 to November 2023 in the following databases: Web of Science, Pubmed, Embase, Cochrane Library, Sinomed, China National Knowledge Internet, Wanfang and VIP. They were evaluated by three subgroups of Traditional Chinese Prescription, Traditional Chinese patent medicines and Traditional Chinese medicine extracts for their common prescriptions, drugs, adverse reactions and the quality of them.Results and Conclusion: TCM has the advantages of multi-target and synergistic treatment in the treatment of elderly diabetes. However, current clinical researches have shortcomings including the inclusion of age criteria and diagnosis of subjects are unclear, imprecise research design, non-standard intervention measures, and its safety needs further exploration. In the future, the diagnosis of elderly people with diabetes needs to be further clarified. Traditional Chinese patent medicines included in the pharmacopoeia can be used to conduct more rigorous RCTs, and then gradually standardize the traditional Chinese medicine prescriptions and traditional Chinese medicine extracts, providing higher level evidence for the treatment of elderly diabetes with traditional Chinese medicine.

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“…Much less is known about the role of mitochondria in other islet cell types, however, these are likely to be important as other islet cells are responsive to glucose, have alternate hormonal action to β-cells, and can impact β-cells activity through a paracrine-and glucose-dependent manner (Capozzi et al, 2019). Another area of interest is the study of inter-organ crosstalk (Evans and Wei, 2022;Langlois et al, 2022), for example, understanding how the gut microbiome impacts β-cell function, survival and inflammation and the role of mitochondria and related-secreted factors/exosomes is an understudied area (Fernandez-Millan and Guillen, 2022;Wei et al, 2023). Overall, our current understanding supports that mitochondrial bioenergetics, metabolism, structure, and biomass are determinants of β-cell health and their dysfunction likely plays a causal role in diabetes development.…”

Section: Conclusion and Additional Considerationsmentioning

confidence: 99%

Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes

Rivera Nieves,

Wauford,

2024

Front. Mol. Biosci.

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In Type 1 and Type 2 diabetes, pancreatic β-cell survival and function are impaired. Additional etiologies of diabetes include dysfunction in insulin-sensing hepatic, muscle, and adipose tissues as well as immune cells. An important determinant of metabolic health across these various tissues is mitochondria function and structure. This review focuses on the role of mitochondria in diabetes pathogenesis, with a specific emphasis on pancreatic β-cells. These dynamic organelles are obligate for β-cell survival, function, replication, insulin production, and control over insulin release. Therefore, it is not surprising that mitochondria are severely defective in diabetic contexts. Mitochondrial dysfunction poses challenges to assess in cause-effect studies, prompting us to assemble and deliberate the evidence for mitochondria dysfunction as a cause or consequence of diabetes. Understanding the precise molecular mechanisms underlying mitochondrial dysfunction in diabetes and identifying therapeutic strategies to restore mitochondrial homeostasis and enhance β-cell function are active and expanding areas of research. In summary, this review examines the multidimensional role of mitochondria in diabetes, focusing on pancreatic β-cells and highlighting the significance of mitochondrial metabolism, bioenergetics, calcium, dynamics, and mitophagy in the pathophysiology of diabetes. We describe the effects of diabetes-related gluco/lipotoxic, oxidative and inflammation stress on β-cell mitochondria, as well as the role played by mitochondria on the pathologic outcomes of these stress paradigms. By examining these aspects, we provide updated insights and highlight areas where further research is required for a deeper molecular understanding of the role of mitochondria in β-cells and diabetes.

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Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes

Cited by 7 publications

References 158 publications

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application

Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes

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