Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma

Grange, Cristina; Brossa, Alessia; Bussolati, Benedetta

doi:10.3390/ijms20081832

Cited by 45 publications

(45 citation statements)

References 110 publications

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“…Exosomes transport a distinct molecular cargo of proteins and nucleic acids (mRNA, miRNA and genomic dNA) in peripheral blood (PB) and other bio-fluids (e.g., urine and saliva), and are recognized as relevant for the diagnosis and prognosis of certain pathologies, particularly solid tumors. Several studies have demonstrated that the proteins and nucleic acids contained within the exosomes of cancer patients can be isolated and identified as exosomal markers associated with cancer evolution (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

et al. 2019

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due to the discovery of their role in intra-cellular communications, exosomes, which carry information specific to the cell of origin, have garnered considerable attention in cancer research. Moreover, there is evidence to suggest the possibility of isolating different exosome sub-populations based on target antigens at the cell surface. Philadelphia chromosome-positive (Ph +) chronic myeloid leukemia (cML) is a clonal myeloproliferative neoplasia characterized by the breakpoint cluster region-proto-oncogene 1 tyrosine-protein kinase (BcR-ABL1) fusion-gene, derived from the t (9;22) translocation. Tyrosine kinase inhibitors (TKIs) target BcR-ABL1 protein and induce major or deep molecular responses in the majority of patients. despite the fact that several studies have demonstrated the persistence of leukemic cells in the bone marrow niche, even following treatment, TKIs prolong patient survival time and facilitate treatment-free remission. These characteristics render cML a plausible model for investigating the feasibility of tumor-derived exosome fraction enrichment. In the present study, patients in the chronic phase (cP) of CML were treated with TKIs, and the quantification of the BCR-ABL1 exosomal transcript was performed using digital PcR (dPcR). The possibility of tumor-derived exosomes enrichment was confirmed, and for the first time, to the best of our knowledge, the detection of the BcR-ABL1 transcript highlighted the presence of active leukemic cells in patients with CP-CML. According to these findings, tumor-derived exosomes may be considered a novel tool for the identification of active leukemic cells, and for the assessment of innovative monitoring focused on the biological functions of exosomes in cML.

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Section: Introductionmentioning

confidence: 99%

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

et al. 2019

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“…The corresponding ligands CXCL12 and CCL21 are present at elevated levels in lymph nodes, lung, liver and bone marrowpreferred distant metastatic sites of breast cancer (288,290). (b) The formation of a pre-metastatic niche (PMN) (290)(291)(292)(293)(294)(295)(296). It is the result of the ability of respective solid tumors, already before tumor cell embolization occurs, to weaken defense mechanisms which are directed against tumor cells in potential host organs.…”

Section: Pathomechanisms Leading To Ispmmentioning

confidence: 99%

“…By disturbing humoral and cellular defense mechanisms in host organs, the subsequent tumor cell embolization and colonization can take place successfully and metastases can form in this organ. The formation of a PMN requires the interaction of three components: primary tumor derived components (273,296,297), tumor mobilized bone marrow derived cells (298) and organ components of the future host organ (292,294,299,300). In pre-metastatic niche formation, the capabilities of tumor cells and host organs are involved, this causes organotropy in niche formation (294).…”

Section: Pathomechanisms Leading To Ispmmentioning

confidence: 99%

Isolated Pancreatic Metastases of Renal Cell Carcinoma—A Paradigm of a Seed and Soil Mechanism: A Literature Analysis of 1,034 Observations

Sellner

2020

Front. Oncol.

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Previously documented arguments, in favor of the suspected impact of a seed and soil mechanism, in the development and progression of isolated pancreatic metastasis of renal cell carcinomas (isPM) are: (1) uniform and independent from the side of the primary tumor distribution of isPM within the pancreas and, (2) the similar survival rates for singular and multiple isPM. In addition, the present study adds new arguments that further confirm the importance of an seed and soil mechanism in isPM: (1) Within the singular isPM, the size of the metastasis does not affect the overall survival; (2) Within the group of multiple isPMs, the overall survival does not depend on the number of metastases; (3) For synchronous and metachronous isPM, survival rates are also not different, and (4) Within the group of metachronous isPM there is also no correlation between the overall survival and interval until metastases occurs. This unusual ineffectiveness of otherwise known risk factors of solid cancers can be explained plausibly by the hypothesis of a very selective seed and soil mechanism in isPM. It only allows embolized renal carcinoma cells in the pancreas to complete all steps required to grow into clinically manifest metastases. In all other organs, on the other hand, the body is able to eliminate the embolized tumor cells or at least put them into a dormant state for many years. This minimizes the risk of occult micrometastases in distant organs, which could later-after isPM treatment-grow into clinically manifest metastases, so that the prognosis of the isPM is only determined by an adequate therapy of the pancreatic foci, and prognostic factors, such as total tumor burden or interval until the occurrence of the isPM remain ineffective.

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“…Moreover, increased levels of miR-210 are directly correlated with poor patient outcomes, suggesting that it could be a potential biomarker for RCC diagnosis and prognosis [27]. The significance of miRNAs in RCC has been comprehensively summarized in a recent excellent review [28]. Accumulating evidence also suggests the involvement and potential importance of lncRNAs in gene regulation in human diseases, including RCC [29,30].…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

et al. 2020

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Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution and diverse cellular functions. They are highly stable and have organ- and tissue-specific expression patterns. CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. Recent reports have shown that circRNAs are abnormally expressed in RCC and act as important regulators of RCC carcinogenesis and progression. Moreover, circRNAs have emerged as potential biomarkers for RCC diagnosis and prognosis and targets for developing new treatments. However, further studies are needed to better understand the functions of circRNAs in RCC. In this review, we summarize and discuss the recent research progress on RCC-associated circRNAs, with a focus on their potential for RCC diagnosis and targeted therapy.

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Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma

Cited by 45 publications

References 110 publications

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

Isolated Pancreatic Metastases of Renal Cell Carcinoma—A Paradigm of a Seed and Soil Mechanism: A Literature Analysis of 1,034 Observations

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

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