Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system

van Griensven, Martijn; Balmayor, Elizabeth R.

doi:10.1016/j.addr.2024.115203

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115203

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Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system

Martijn van Griensven,

Elizabeth R. Balmayor

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Cited by 7 publications

References 165 publications

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Adipogenic differentiation effect of human periodontal ligament stem cell initial cell density on autologous cells and human bone marrow stromal cells

Wang,

Gu,

Sun

et al. 2024

Cell Biochemistry & Function

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Stem cells demonstrate differentiation and regulatory functions. In this discussion, we will explore the impacts of cell culture density on stem cell proliferation, adipogenesis, and regulatory abilities. This study aimed to investigate the impact of the initial culture density of human periodontal ligament stem cells (hPDLSCs) on the adipogenic differentiation of autologous cells. Our findings indicate that the proliferation rate of hPDLSCs increased with increasing initial cell density (0.5–8 × 104 cells/cm2). After adipogenic differentiation induced by different initial cell densities of hPDLSC, we found that the mean adipose concentration and the expression levels of lipoprotein lipase (LPL), CCAAT/enhancer binding protein α (CEBPα), and peroxisome proliferator‐activated receptor γ (PPAR‐γ) genes all increased with increasing cell density. To investigate the regulatory role of hPDLSCs in the adipogenic differentiation of other cells, we used secreted exocrine vesicles derived from hPDLSCs cultivated at different initial cell densities of 50 μg/mL to induce the adipogenic differentiation of human bone marrow stromal cells. We also found that the mean adipose concentration and expression of LPL, CEBPα, and PPARγ genes increased with increasing cell density, with an optimal culture density of 8 × 104 cells/cm2. This study provides a foundation for the application of adipogenic differentiation in stem cells.

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Adipogenic differentiation effect of human periodontal ligament stem cell initial cell density on autologous cells and human bone marrow stromal cells

Wang,

Gu,

Sun

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

Synergistic effects of curcumin and stem cells on spinal cord injury: a comprehensive review

Arefnezhad,

Jahandideh,

Rezaei

et al. 2024

Mol Biol Rep

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Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy?

Al-Ward,

Chen,

Gao

et al. 2024

Stem Cell Rev and Rep

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Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system

Cited by 7 publications

References 165 publications

Adipogenic differentiation effect of human periodontal ligament stem cell initial cell density on autologous cells and human bone marrow stromal cells

Adipogenic differentiation effect of human periodontal ligament stem cell initial cell density on autologous cells and human bone marrow stromal cells

Synergistic effects of curcumin and stem cells on spinal cord injury: a comprehensive review

Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy?

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