Extracellular Vesicles Derived from Mesenchymal Stem Cells

Gomzikova, Marina O.; James, Victoria; Rizvanov, Albert A.

doi:10.1007/978-981-19-2655-6_48

Cited by 2 publications

(1 citation statement)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another method to potentially reduce immune rejection could be through the encapsulation of mitochondria by microvesicles or liposomes. It has been proven that the membrane of extracellular vesicles aids in maintaining the functional integrity and lifespan of mitochondria in the bloodstream [114,115]. To further improve the uptake and targeting efficacy, extra modifications could be made to the membranes of these transport vehicles, as discussed previously (Fig.…”

Section: Mitochondria: a Potential Rejuvenation Tool Against Agingmentioning

confidence: 99%

Mitochondria: A Potential Rejuvenation Tool against Aging

2023

Aging dis

View full text Add to dashboard Cite

Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related diseases. In response to the remarkable increase in human life expectancy, there has been a substantial rise in research focusing on the development of anti-aging therapies and pharmacological interventions. Mitochondrial dysfunction, a critical factor in the aging process, significantly impacts overall cellular health. In this extensive review, we will explore the contemporary landscape of anti-aging strategies, placing particular emphasis on the promising potential of mitotherapy as a ground-breaking approach to counteract the aging process. Moreover, we will investigate the successful application of mitochondrial transplantation in both animal models and clinical trials, emphasizing its translational potential. Finally, we will discuss the inherent challenges and future possibilities of mitotherapy within the realm of aging research and intervention.

show abstract

Section: Mitochondria: a Potential Rejuvenation Tool Against Agingmentioning

confidence: 99%

Mitochondria: A Potential Rejuvenation Tool against Aging

2023

Aging dis

View full text Add to dashboard Cite

show abstract

Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies

Salomon

2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundCerebral palsy (CP) is a common neurodevelopmental disorder characterized by impaired mobility and posture caused by brain injury or abnormal development. CP relates to a variety of neurological mechanisms and pathways that impact the type and severity of motor disability, as well as comorbidities. The heterogeneity in clinical phenotype, pathogenesis, and etiology poses significant challenges for effective therapeutic intervention.ObjectivesThe review aims to provide a comprehensive analysis of the neurobiological mechanisms underlying CP and evaluate current and prospective therapeutic strategies, highlighting the necessity for targeted interventions to address the disorder's multifaceted nature.MethodsA thorough literature review was conducted, focusing on studies published in peer‐reviewed journals that explore the pathophysiological mechanisms, clinical interventions, and therapeutic strategies for CP.ResultsThe pathogenesis of CP involves a complex interplay of genetic, environmental, and perinatal factors leading to brain injury. Inflammatory processes, oxidative stress, and excitotoxicity are critical in CP development. Current therapeutic approaches primarily focus on symptom management through physical and occupational therapy, as well as pharmacological interventions. Emerging therapies, including anti‐inflammatory agents, antioxidants, and neuroprotective and neurotrophic agents, show potential but require further validation. Notably, although steroids provide anti‐inflammatory benefits, their use in pediatric patients raises concerns regarding long‐term adverse effects such as osteoporosis.ConclusionDespite advances in understanding CP's neurobiological underpinnings, effective therapeutic targets remain elusive. A comprehensive approach addressing CP's heterogeneity is essential. Future research should emphasize in‐depth evaluations of the efficacy and safety of therapeutic agents, particularly in pediatric populations, to develop targeted and effective treatments for CP.

show abstract

Extracellular Vesicles Derived from Mesenchymal Stem Cells

Cited by 2 publications

References 133 publications

Mitochondria: A Potential Rejuvenation Tool against Aging

Mitochondria: A Potential Rejuvenation Tool against Aging

Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies

Contact Info

Product

Resources

About