Extracellular vesicles for improved tumor accumulation and penetration

Bie, Nana; Yong, Tuying; Wei, Zhaohan; Gan, Lu; Yang, Xiangliang

doi:10.1016/j.addr.2022.114450

Cited by 37 publications

(21 citation statements)

References 165 publications

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“…The circulation stability of MP‐based drug‐delivery systems limited their intracellular drug release, restricting their anticancer therapeutic efficacy. [ 9,10 ] In this work, the in vitro drug release analysis showed that DOX@SP‐MPs exhibited the highest DOX release at pH 4.5 and 37 °C compared with DOX@MPs and DOX@IP‐MPs. Moreover, intracellular DOX trafficking analysis also revealed that more DOX was translocated from lysosomes to nuclei in DOX@SP‐MPs‐treated cells, confirming that DOX@SP‐MPs can efficiently release DOX in lysosomes after internalization into tumor cells and CSCs.…”

Section: Discussionmentioning

confidence: 76%

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Hydrophobicity‐Adaptive Polymers Trigger Fission of Tumor‐Cell‐Derived Microparticles for Enhanced Anticancer Drug Delivery

Liu,

Xu,

Yong

et al. 2023

Advanced Materials

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Tumor‐cell‐derived microparticles (MPs) can function as anticancer drug‐delivery carriers. However, short blood circulation time, large‐size‐induced insufficient tumor accumulation and penetration into tumor parenchyma, as well as limited cellular internalization by tumor cells and cancer stem cells (CSCs), and difficult intracellular drug release restrict the anticancer activity of tumor‐cell‐derived MP‐based drug‐delivery systems. In this work, hydrophobicity‐adaptive polymers based on poly(N‐isopropylacrylamide) are anchored to tumor‐cell‐derived MPs for enhanced delivery of the anticancer drug doxorubicin (DOX). The polymers are hydrophilic in blood to prolong the circulation time of DOX‐loaded MPs (DOX@MPs), while rapidly switching to hydrophobic at the tumor acidic microenvironment. The hydrophobicity of polymers drives the fission of tumor‐cell‐derived MPs to form small vesicles, facilitating tumor accumulation, deep tumor penetration, and efficient internalization of DOX@MPs into tumor cells and CSCs. Subsequently, the hydrophobicity of polymers in acidic lysosomes further promotes DOX release to nuclei for strong cytotoxicity against tumor cells and CSCs. The work provides a facile and simple strategy for improved anticancer drug delivery of tumor‐cell‐derived MPs.

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Section: Discussionmentioning

confidence: 76%

“…[7,8] In addition, the insufficient intracellular drug release of MP-based drugdelivery systems after internalization into tumor cells and CSCs further prevented to exert anticancer activity. [9,10] Thus, improving the drug-delivery efficiency of tumor-cell-derived MPs will contribute to increasing their anticancer therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobicity‐Adaptive Polymers Trigger Fission of Tumor‐Cell‐Derived Microparticles for Enhanced Anticancer Drug Delivery

Liu,

Xu,

Yong

et al. 2023

Advanced Materials

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“…Thus, EVs are able to penetrate tissue and cells deeper. 173 It should be noted that EVs (particularly stem cell-derived EVs) are typically less effective due to a lack of targeting ability in the heart and in the infarct region. 174 The recently developed injectable hydrogels show the potential to conquer this issue.…”

Section: Cell or Cell Derivative-laden Hydrogels For MI Therapymentioning

confidence: 99%

Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Xiong,

An,

Chen

et al. 2023

J. Mater. Chem. B

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“…Because of their biological signals, exosomes can be seen as an enhanced drug delivery method for cancer treatment. Compared to synthetic drug carriers like synthetic polymer-based nanoparticles, micellar systems, liposomes, etc., exosomes have unique, innate properties, including tumor targeting and interaction with tumor vessels and stroma, which makes them capable of delivering drugs deep inside tumors despite tissue and cellular barriers [ 130 ]. Exosomes can be indicated as a less drastic approach to diagnosing cancer.…”

Section: Therapeutic Applications Of Exosomesmentioning

confidence: 99%

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

Rajput

Varshney²,

Bajaj³

et al. 2022

Molecules

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Currently, particular interest among the scientific community is focused on exploring the use of exosomes for several pharmaceutical and biomedical applications. This is due to the identification of the role of exosomes as an excellent intercellular communicator by delivering the requisite cargo comprising of functional proteins, metabolites and nucleic acids. Exosomes are the smallest extracellular vesicles (EV) with sizes ranging from 30–100 nm and are derived from endosomes. Exosomes have similar surface morphology to cells and act as a signal transduction channel between cells. They encompass different biomolecules, such as proteins, nucleic acids and lipids, thus rendering them naturally as an attractive drug delivery vehicle. Like the other advanced drug delivery systems, such as polymeric nanoparticles and liposomes to encapsulate drug substances, exosomes also gained much attention in enhancing therapeutic activity. Exosomes present many advantages, such as compatibility with living tissues, low toxicity, extended blood circulation, capability to pass contents from one cell to another, non-immunogenic and special targeting of various cells, making them an excellent therapeutic carrier. Exosome-based molecules for drug delivery are still in the early stages of research and clinical trials. The problems and clinical transition issues related to exosome-based drugs need to be overcome using advanced tools for better understanding and systemic evaluation of exosomes. In this current review, we summarize the most up-to-date knowledge about the complex biological journey of exosomes from biogenesis and secretion, isolation techniques, characterization, loading methods, pharmaceutical and therapeutic applications, challenges and future perspectives of exosomes.

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Extracellular vesicles for improved tumor accumulation and penetration

Cited by 37 publications

References 165 publications

Hydrophobicity‐Adaptive Polymers Trigger Fission of Tumor‐Cell‐Derived Microparticles for Enhanced Anticancer Drug Delivery

Hydrophobicity‐Adaptive Polymers Trigger Fission of Tumor‐Cell‐Derived Microparticles for Enhanced Anticancer Drug Delivery

Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

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