2020
DOI: 10.3390/v12020239
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Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line

Abstract: In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an oxidative stress pathway. To test the hypothesis, we treated an HIV-1-infected macrophage cell line (U1) with HPV-infected Caski cell culture supernatant (CCS). We observed a significant increase in HIV-1 replication, which was associated with an increase in the expre… Show more

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Cited by 17 publications
(16 citation statements)
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“…During infection, EVs can amplify inflammation and deflagrate antiviral responses (Urbanelli et al, 2019) and can also mediate communication between immune cells and other cell types (Isola and Chen, 2017). The involvement of EVs in viral infection and/or host interactions in disease has already been described for several viruses, such as rabies (Wang et al, 2019b), coronaviruses (Maeda et al, 1999;Kuate et al, 2007;Börger et al, 2020;Deffune et al, 2020;Hassanpour et al, 2020;Inal, 2020a;Inal, 2020b;Kumar et al, 2020;O'Driscoll, 2020;Tsuchiya et al, 2020;Urciuoli and Peruzzi, 2020), HCV (Bartosch et al, 2003;Timpe et al, 2008;Dreux et al, 2012;Bukong et al, 2014), HBV (Jia et al, 2017;, HIV (Princen et al, 2004;Khatua et al, 2009;Xu et al, 2009;Lenassi et al, 2010;Bernard et al, 2014;Raymond et al, 2016;Sampey et al, 2016;Kodidela et al, 2018;Haque et al, 2020;Ranjit et al, 2020), HPV (Honegger et al, 2015;Guenat et al, 2017;Sadri Nahand et al, 2019;Chiantore et al, 2020), HSV (Temme et al, 2010;Han et al, 2016;Deschamps and Kalamvoki, 2018) dengue (Martins et al, 2018;…”
Section: Evs In Immune Communication and Cytokine Responses During Inmentioning
confidence: 98%
See 1 more Smart Citation
“…During infection, EVs can amplify inflammation and deflagrate antiviral responses (Urbanelli et al, 2019) and can also mediate communication between immune cells and other cell types (Isola and Chen, 2017). The involvement of EVs in viral infection and/or host interactions in disease has already been described for several viruses, such as rabies (Wang et al, 2019b), coronaviruses (Maeda et al, 1999;Kuate et al, 2007;Börger et al, 2020;Deffune et al, 2020;Hassanpour et al, 2020;Inal, 2020a;Inal, 2020b;Kumar et al, 2020;O'Driscoll, 2020;Tsuchiya et al, 2020;Urciuoli and Peruzzi, 2020), HCV (Bartosch et al, 2003;Timpe et al, 2008;Dreux et al, 2012;Bukong et al, 2014), HBV (Jia et al, 2017;, HIV (Princen et al, 2004;Khatua et al, 2009;Xu et al, 2009;Lenassi et al, 2010;Bernard et al, 2014;Raymond et al, 2016;Sampey et al, 2016;Kodidela et al, 2018;Haque et al, 2020;Ranjit et al, 2020), HPV (Honegger et al, 2015;Guenat et al, 2017;Sadri Nahand et al, 2019;Chiantore et al, 2020), HSV (Temme et al, 2010;Han et al, 2016;Deschamps and Kalamvoki, 2018) dengue (Martins et al, 2018;…”
Section: Evs In Immune Communication and Cytokine Responses During Inmentioning
confidence: 98%
“…EVs facilitate viral transmission HSV-1 (Bello-Morales and López-Guerrero, 2020), KSHV (Chen et al, 2020)., NDV (Zhou C. et al, 2019), PRRSV (Wang et al, 2017), enterovirus 71 (Gu et al, 2020), HCV (Bukong et al, 2014), HIV (Kadiu et al, 2012), SFTS (Silvas et al, 2016) Viral RNAs/proteins inside EVs Coronavirus (Maeda et al, 1999), EBV (Keryer-Bibens et al, 2006), HCV (Kouwaki et al, 2017)., HTLV-1, (Jaworski et al, 2014), RVFV (Ahsan et al, 2016), ZIKV (Zhou W. et al, 2019;MartıƄez-Rojas et al, 2020) Infectious virus-like particles/cloaked virions inside EVs DENV (Reyes-Ruiz et al, 2019), enterovirus 71 (Gu et al, 2020), HCV (Bartosch et al, 2003;Timpe et al, 2008) Transfer of infective RNA through EVs withouth complete viral particles HCV (Longatti et al, 2015), FMDV (Zhang et al, 2019), EVs turn cells more permissive to infection, membrane/receptor modulation HIV (Arenaccio et al, 2014;Dubrovsky et al, 2020), Rhinovirus (Miura, 2019) Host molecules in EVs facilitate viral stability and replication in recipient cells HBV , HCV (Bukong et al, 2014;Altan-Bonnet, 2016), HIV (Arenaccio et al, 2014;Ranjit et al, 2020) Amplification of EV production ZIKV (Zhou W. et al, 2019) EVs from uninfected cells can activate latent viruses HIV (Barclay et al, 2020) EVS RELATED TO IMMUNE RESPONSES…”
Section: Mechanism Virusmentioning
confidence: 99%
“…Some oxidative stress-related proteins have been reported in EVs of cervical cancer, such as the cytochrome P450 family proteins CYP1A1, CYP1B, and CYP2A6, as well as the antioxidant enzyme superoxide dismutase 1 (SOD1). These EVs isolated from the CaSki cell line are taken up by the U1 cell line of macrophages infected with HIV-1 and increase HIV-1 replication through the CYP pathways and oxidative stress by increasing ROS levels and decreasing antioxidant capacity, cell death, and DNA damage in U1 cells [ 24 ].…”
Section: Protein Cargo In Extracellular Vesiclesmentioning
confidence: 99%
“…EVs may also mediate the interaction between the human papilloma virus (HPV) and human immunodeficiency virus (HIV)-1. In this way, exosomes secreted from cells infected with HPV may increase HIV-1 replication in U1 cells via an oxidative stress pathway and treatment with antioxidants reduced EV-mediated enhancement of HIV-1 replication [ 72 ].…”
Section: Evs In Viral Infectionsmentioning
confidence: 99%