Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

Rao, Shanshan; He, Zehui; Wang, Zun; Yin, Hao; Hu, Xiongke; Tan, Yijuan; Wan, Tengfei; Zhu, Hao; Luo, Yi; Wang, Xin; Li, Hongming; Wang, Zhenxing; Hu, Xinyue; Hong, Chungu; Wang, Yiyi; Luo, Mingjie; Du, Wei; Qian, Yuxuan; Tang, Siyuan; Xie, Hui; Chen, Chunyuan

doi:10.1016/j.apsb.2023.12.009

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2024

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Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway

Chen,

Liu,

Wang

et al. 2024

Acta Pharmaceutica Sinica B

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Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway

Chen,

Liu,

Wang

et al. 2024

Acta Pharmaceutica Sinica B

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Feasibility of intravenous injections of pig plasma extracellular particles into rats — an acute study

Cherñavsky,

de Campos Zani,

Mori

et al. 2024

Preprint

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Background: Extracellular particles (EPs), especially small extracellular vesicles (EVs), extracted from young animals are increasingly being studied in animal models as agents for regeneration and rejuvenation, with studies using EPs from one species injected into another showing no immune reaction. In this study, we aimed to investigate if the injection of Pig Plasma Extracellular Particles (PPEPs) into rats would produce an acute immune or toxic reaction. Methods: Blood from a young pig was collected, PPEPs were isolated by size exclusion chromatography and injected into young male Sprague-Dawley rats, while the control group received a sterile saline injection. After 9 days, the animals were euthanized and their organs were histologically analyzed for signs of cellular damage or immune infiltration. Results: The treated rats showed no signs of acute immunological reaction, behaving normally immediately after the injections and during the 9 days since the first injection. Throughout the trial period, the animals continued gaining weight normally and the histological analysis of their liver, kidney and spleen showed no signs of acute toxicity. Conclusions: PPEPs from young animals do not cause an acute immune or toxic response when injected intravenously into young male Sprague-Dawley rats.

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Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

Cited by 2 publications

References 64 publications

Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway

Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway

Feasibility of intravenous injections of pig plasma extracellular particles into rats — an acute study

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