Extracellular vesicles from Leishmania (Leishmania) infantum contribute to stimulate the immune response and immunosuppression in hosts with visceral leishmaniasis
Francieli Marinho Carneiro,
Allecineia Bispo Da Cruz,
Marta Marques Maia
et al.
Abstract:Visceral leishmaniasis (VL) is a chronic systemic disease. In Brazil this infection is caused by Leishmania (Leishmania) infantum. Extracellular vesicles (EVs) released by Leishmania species have different functions like modulation of host immune system, inflammatory response, among others. This study evaluated the participation of EVs from L. (L.) infantum (Leish-EVs) in stimulation of the humoral and cellular immune responses of hosts with VL. Promastigotes were cultivated in 199 medium and, in the log phase… Show more
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