Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Michel, Lauriane Y. M.

doi:10.3390/ijms24097745

Cited by 13 publications

(4 citation statements)

References 120 publications

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“…EVs were also shown to be secreted by the adipose tissue [ 99 ]. A lipidomic analysis was recently performed on adipocyte-derived EVs derived from adipose tissue of lean and obese mice [ 100 ], and a specific ceramide enrichment was observed in adipocyte-derived EVs compared to the original adipose tissue (visceral adipose tissue), regardless of the metabolic status [ 100 ].…”

Section: Ceramides and Extracellular Vesiclesmentioning

confidence: 99%

Circulating Sphingolipids and Glucose Homeostasis: An Update

Ali-Berrada,

Guitton,

Tan-Chen

et al. 2023

IJMS

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Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. Of all sphingolipids, two species, ceramides and sphingosine-1-phosphate (S1P), are also found abundantly secreted into the bloodstream and associated with lipoproteins or extracellular vesicles. Plasma concentrations of these sphingolipids can be altered upon metabolic disorders and could serve as predictive biomarkers of these diseases. Recent important advances suggest that circulating sphingolipids not only serve as biomarkers but could also serve as mediators in the dysregulation of glucose homeostasis. In this review, advances of molecular mechanisms involved in the regulation of ceramides and S1P association to lipoproteins or extracellular vesicles and how they could alter glucose metabolism are discussed.

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Section: Ceramides and Extracellular Vesiclesmentioning

confidence: 99%

Circulating Sphingolipids and Glucose Homeostasis: An Update

Ali-Berrada,

Guitton,

Tan-Chen

et al. 2023

IJMS

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“…Still, there are relatively few studies that have investigated whether sEV mediate the connections between AT and the brain and influence central inflammation ( 130 , 131 ) ( Figure 1 ). Currently, researchers are also studying the role of native ( 132 ), stem cell-derived ( 127 , 133 ), and bioengineered sEVs ( 134 – 136 )in other metabolic tissues, which may lead to improved understanding of whole-body metabolic control and therapeutic approaches to obesity.…”

Section: Small Extracellular Vesicles In Cellular- and Tissue Crosstalkmentioning

confidence: 99%

Peripheral and central macrophages in obesity

Mukherjee,

Skrede,

Haugstøyl

et al. 2023

Front. Endocrinol.

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Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells from the circulation as well as activation of cells that are residing in the adipose tissue. In particular, the adipose tissue macrophages (ATMs) are important in the pathogenesis of obesity. A pro-inflammatory activation is also found in other organs which are important for energy metabolism, such as the liver, muscle and the pancreas, which may stimulate the development of obesity-related co-morbidities, including insulin resistance, type 2 diabetes (T2D), cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Interestingly, it is now clear that obesity-induced pro-inflammatory signaling also occurs in the central nervous system (CNS), and that pro-inflammatory activation of immune cells in the brain may be involved in appetite dysregulation and metabolic disturbances in obesity. More recently, it has become evident that microglia, the resident macrophages of the CNS that drive neuroinflammation, may also be activated in obesity and can be relevant for regulation of hypothalamic feeding circuits. In this review, we focus on the action of peripheral and central macrophages and their potential roles in metabolic disease, and how macrophages interact with other immune cells to promote inflammation during obesity.

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“…Extracellular vesicles (EVs), as one type of membrane-enclosed nanoparticle, are attractive mediators of intercellular and inter-organ communication in various diseases, including HF [46][47][48][49]. Currently, EVs are divided into three types of vesicles in terms of their origin and mechanisms of biogenesis [50] (see Figure 1): (1) Exosomes (EXOs) (50-160 nm);…”

Section: Mirnas and Extracellular Vesicle Biogenesismentioning

confidence: 99%

Extracellular Vesicle MicroRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Tian,

Ziegler,

Zucker

2023

Cells

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Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs is tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, particularly circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.

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Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Cited by 13 publications

References 120 publications

Circulating Sphingolipids and Glucose Homeostasis: An Update

Circulating Sphingolipids and Glucose Homeostasis: An Update

Peripheral and central macrophages in obesity

Extracellular Vesicle MicroRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

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