Extracellular Vesicles in Cancer Progression: Are They Part of The Problem or Part of The Solution?

Scholl, Juliete Nathali; Dias, Camila Kehl; Müller, Laurent; Battastini, Ana Maria Oliveira; Figueiró, Fabrício

doi:10.2217/nnm-2020-0256

Cited by 8 publications

(7 citation statements)

References 153 publications

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“…It is known that the GBM microenvironment is rich in signaling pathways [ 12 ]. Extracellular vesicles (EVs) play a role as mediators of intercellular communication in the TME, which are able to modulate immune responses; however, their function in tumor growth is not clear [ 54 ]. In fact, it was demonstrated that glioma cells release microvesicles which can stimulate angiogenesis and promote tumor growth in a human glioma cell line [ 55 ].…”

Section: Glioma Microenvironmentmentioning

confidence: 99%

“…In fact, it was demonstrated that glioma cells release microvesicles which can stimulate angiogenesis and promote tumor growth in a human glioma cell line [ 55 ]. Otherwise, a recent study has shown that glioma-derived extracellular vesicles (GEVs) have antiproliferative properties and reduced regulatory T cells in the glioma microenvironment [ 54 ].…”

Section: Glioma Microenvironmentmentioning

confidence: 99%

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P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment

et al. 2021

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Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor’s aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) strongly increase in the extracellular space, and the purinergic signaling is triggered by nucleotides’ interaction in P2 receptors. Several cell types are present in the tumor microenvironment and can facilitate tumor growth. In fact, tumor cells can activate platelets by the ADP-P2Y12 engagement, which plays an essential role in the cancer context, protecting tumors from the immune attack and providing molecules that contribute to the growth and maintenance of a rich environment to sustain the protumor cycle. Besides platelets, the P2Y12 receptor is expressed by some tumors, such as renal carcinoma, colon carcinoma, and gliomas, being related to tumor progression. In this context, this review aims to depict the glioma microenvironment, focusing on the relationship between platelets and tumor malignancy.

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Section: Glioma Microenvironmentmentioning

confidence: 99%

Section: Glioma Microenvironmentmentioning

confidence: 99%

P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment

et al. 2021

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“…EVs are nanosized particles which are key players in intercellular communications [ 39 ] and have gathered a lot of attention as potential biomarkers of cancer development and progression [ 40 , 41 ]. For example, increased concentration of cancer-derived EVs was found in patients with many cancer types, including breast cancer [ 42 ], prostate cancer [ 43 ], or lung cancer [ 44 ].…”

Section: Anticancerogenic Effectmentioning

confidence: 99%

Pleiotropic Effects of Acetylsalicylic Acid after Coronary Artery Bypass Grafting—Beyond Platelet Inhibition

Siwik

Gajewska

Karoń

et al. 2021

JCM

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Acetylsalicylic acid (ASA) is one of the most frequently used medications worldwide. Yet, the main indications for ASA are the atherosclerosis-based cardiovascular diseases, including coronary artery disease (CAD). Despite the increasing number of percutaneous procedures to treat CAD, coronary artery bypass grafting (CABG) remains the treatment of choice in patients with multivessel CAD and intermediate or high anatomical lesion complexity. Taking into account that CABG is a potent activator of inflammation, ASA is an important part in the postoperative therapy, not only due to ASA antiplatelet action, but also as an anti-inflammatory agent. Additional benefits of ASA after CABG include anticancerogenic, hypotensive, antiproliferative, anti-osteoporotic, and neuroprotective effects, which are especially important in patients after CABG, prone to hypertension, graft occlusion, atherosclerosis progression, and cognitive impairment. Here, we discuss the pleiotropic effects of ASA after CABG and provide insights into the mechanisms underlying the benefits of treatment with ASA, beyond platelet inhibition. Since some of ASA pleiotropic effects seem to increase the risk of bleeding, it could be considered a starting point to investigate whether the increase of the intensity of the treatment with ASA after CABG is beneficial for the CABG group of patients.

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“…They are involved in cell-to-cell communication, immune response, angiogenesis, and signal transduction [ 14 ]. Many cancer cells release EVs, thereby affecting tumor microenvironments and suppressing or, surprisingly, stimulating immune responses, leading to a delicate balance of immune modulation [ 15 ]. Tumor-derived EVs were shown to avoid perforin-mediated elimination by CD8+ lymphocytes, a function in which their adenosine content seems to play a pivotal role [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Exosomes in Cancer Progression

Soltész

Buglyó

Nemeth

et al. 2021

IJMS

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Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the formation of tumor microenvironments and causing metastases. EVs were discovered more than seventy years ago. They have been tested recently as tools of drug delivery to treat cancer. Here we give a brief review on extracellular vesicles, exosomes, microvesicles and apoptotic bodies. Exosomes play an important role by carrying extracellular nucleic acids (DNA, RNA) in cell-to-cell communication causing tumor and metastasis development. We discuss the role of extracellular vesicles in the pathogenesis of cancer and their practical application in the early diagnosis, follow up, and next-generation treatment of cancer patients.

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Extracellular Vesicles in Cancer Progression: Are They Part of The Problem or Part of The Solution?

Cited by 8 publications

References 153 publications

P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment

P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment

Pleiotropic Effects of Acetylsalicylic Acid after Coronary Artery Bypass Grafting—Beyond Platelet Inhibition

The Role of Exosomes in Cancer Progression

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