Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools

Cela, Ilaria; Capone, Emily; Trevisi, Gianluca; Sala, Gianluca

doi:10.1016/j.semcancer.2024.04.003

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2024

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Cited by 5 publications

References 200 publications

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Extracellular vesicles and biomarker discovery

Falasca,

Manfredi

2024

Seminars in Cancer Biology

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Extracellular vesicles and biomarker discovery

Falasca,

Manfredi

2024

Seminars in Cancer Biology

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An updated review on the development of a nanomaterial-based field-effect transistor-type biosensors to detect exosomes for cancer diagnosis

An,

Park,

et al. 2024

Talanta

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GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment

Zheng,

Ke,

Zhao

et al. 2024

Preprint

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Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing to challenging hindrances in conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping the immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated with doxorubicin (DOX), and Angiopep-2 (Ang) for the magnetic resonance imaging-guided enhanced chemotherapy of glioma. The role of Ang promotes BBB penetration and tumor cell targeting, while TPP allows for an increased concentration of the Ang-PMT NPs in the mitochondria. Upon exposure to high concentration of glutathione (GSH) within the TME, the Ang-PMT NPs disintegrate rapidly, resulting in the production of Mn2+ and the subsequent release of DOX. The released DOX directly eradicates tumor cells and catalyzes mitochondrial DNA release, leading to immunogenic cell death (ICD) and the activation of the cGAS-STING pathway. Furthermore, the produced Mn2+ also activates the cGAS-STING pathway, thereby reshaping the TME and enhancing chemotherapy for glioma. The multifunctional nanoplatform demonstrated a notable inhibition of tumor growth in comparison to the control groups. It is anticipated that this innovative approach may offer promising prospects for the management of malignant glioma in clinical management.

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Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools

Cited by 5 publications

References 200 publications

Extracellular vesicles and biomarker discovery

Extracellular vesicles and biomarker discovery

An updated review on the development of a nanomaterial-based field-effect transistor-type biosensors to detect exosomes for cancer diagnosis

GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment

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