Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges

De Stefano, Nicola; Calleri, Alberto; Faini, Angelo Corso; Navarro-Tableros, Victor; Martini, Silvia; Deaglio, Silvia; Patrono, Damiano; Romagnoli, Renato

doi:10.3390/ijms241713547

Cited by 4 publications

(1 citation statement)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(33)(34)(35). Exosome cytoplasm involves microRNA (miRNA), long noncoding RNA (lncRNA), messenger RNA (mRNA), proteins, lipids, and lots of other active ingredients (36)(37)(38). Exosomes may deliver the active ingredients, which they convey to the target cells through mutual fusion with the cell membranes of the recipient cells, cytosis, and other modes of action to impact the function of recipient cells (39)(40)(41).…”

Section: Introductionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment within which the cancer cells reside. Tumor-associated macrophages (TAMs) primarily differentiate from peripheral blood monocytes and can be broadly categorized into M1 and M2 subtypes. M2-type TAMs have been shown to promote tumor growth, tissue remodeling, and angiogenesis. Furthermore, they can actively suppress acquired immunity, leading to a poorer prognosis and reduced tolerance to chemotherapy. Exosomes, which contain a myriad of biologically active molecules including lipids, proteins, mRNA, and noncoding RNAs, have emerged as key mediators of communication between tumor cells and TAMs. The exchange of these molecules via exosomes can markedly influence the tumor microenvironment and consequently impact tumor progression. Recent studies have elucidated a correlation between TAMs and various clinicopathological parameters of GC, such as tumor size, differentiation, infiltration depth, lymph node metastasis, and TNM staging, highlighting the pivotal role of TAMs in GC development and metastasis. In this review, we aim to comprehensively examine the bidirectional communication between GC cells and TAMs, the implications of alterations in the tumor microenvironment on immune escape, invasion, and metastasis in GC, targeted therapeutic approaches for GC, and the efficacy of potential GC drug resistance strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Extracellular vesicles

Gonçalves,

Di Iorio,

Marin

et al. 2024

Current Topics in Membranes

View full text Add to dashboard Cite

Liver transplantation for tumor entities

Patrono,

De Stefano,

Romagnoli

2024

Current Opinion in Organ Transplantation

Self Cite

View full text Add to dashboard Cite

Purpose of review Tumor entities represent an increasing indication for liver transplantation (LT). This review addresses the most contentious indications of LT in transplant oncology. Recent findings Patient selection based on tumor biology in LT for colorectal cancer liver metastases (CRLM) demonstrated promising long-term outcomes and preserved quality of life despite high recurrence rates. In selected cases, LT for intrahepatic cholangiocarcinoma (iCCA) is feasible, with acceptable survival even in high-burden cases responsive to chemotherapy. LT following a strict neoadjuvant protocol for perihilar cholangiocarcinoma (pCCA) resulted in long-term outcomes consistently surpassing benchmark values, and potentially outperforming liver resection. Summary While preliminary results are promising, prospective trials are crucial to define applications in routine clinical practice. Molecular profiling and targeted therapies pave the way for personalized approaches, requiring evolving allocation systems for equitable LT access.

show abstract

Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges

Cited by 4 publications

References 125 publications

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Extracellular vesicles

Liver transplantation for tumor entities

Contact Info

Product

Resources

About