Extracellular Vesicles in Metabolism and Metabolic Diseases

Marzan, Akbar L.; Nedeva, Christina

doi:10.1007/978-3-030-67171-6_15

Cited by 12 publications

(9 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More specifically, Troponin, LDH, CK-Mb, and CPK levels were significantly higher in the EAC group than in the control group. LDH plays a major role in tumor onset and metabolism [13]. In the present study, excessive levels of LDH were observed in mice carrying EAC, which could have been due to cardiac toxicity, or rapid tumor cell metabolism.…”

Section: Discussionsupporting

confidence: 48%

The Effect of Vitamin B17 on Cardiomyopathy against Ehrlich Tumor Development in Female Mice

El-Malla

Elmetwalli²,

Rizk

et al. 2021

Biochemistry Letters

View full text Add to dashboard Cite

The transplantable tumor model of Ehrlich ascites tumor (EAC), which is a cancer simulation, is frequently used to study the antineoplastic effects of amygdalin (VB17). This study aims to find out how cardiac toxicity and oxidative stress triggered by EAC could be countered with VB17 in female mice. Twenty-five female mice were included and divided into 5 groups namely, the control group (Gp1), EAC (Gp2), VB17 control group (Gp3), EAC+VB17 (Gp4), EAC+VB17+SOR IP (Gp5). All groups underwent cardiac marker assessment in addition to oxidative stress marker MDA determination and the evaluation of the anti-oxidative stress marker of SOD. By comparison with the naïve control group, the EAC positive control group had a significantly higher level of Troponin, serum lactate dehydrogenase (LDH), CK-MB, CPK, and MDA content. On the other hand, the EAC group had significantly lower levels of cardiac SOD than the control group. Furthermore, better improvement in cardiac toxicity and oxidative stress was displayed by the cotreated (VB17+SOR) group 5 than by the (EAC + VB17) group 4. This led to the conclusion that VB17 conferred cardiac protective and antioxidant effects against EAC. This finding necessitates further research into the benefits of VB17 as adjuvant agents in the prevention and treatment of cardiac toxicity.

show abstract

Section: Discussionsupporting

confidence: 48%

The Effect of Vitamin B17 on Cardiomyopathy against Ehrlich Tumor Development in Female Mice

El-Malla

Elmetwalli²,

Rizk

et al. 2021

Biochemistry Letters

View full text Add to dashboard Cite

show abstract

“…All eukaryotes can secrete EVs and exhibit a snapshot of the secreting cells, encapsulating active and specific biomolecules from the donor cell ( Marzan and Stewart, 2021 ). Once EVs are produced in the extracellular space, these nanosized particles can be uptake by recipient cells, and in turn act as messengers and perform biological functions via the delivery of plenty of functional biomolecules including proteins, nucleic acids, lipids, and metabolites, into recipient cells, both near and far from the secreting cell ( Palviainen et al, 2019 ; Marzan et al, 2021 ). Currently, there are three main subsets of EVs: exosomes, microvesicles, and apoptotic bodies.…”

Section: The Characteristics and Biogenesis Of Extracellularvesiclesmentioning

confidence: 99%

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

Kang

Xin

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Neurons and neurogliocytes (oligodendrocytes, astrocytes, and microglia) are essential for maintaining homeostasis of the microenvironment in the central nervous system (CNS). These cells have been shown to support cell-cell communication via multiple mechanisms, most recently by the release of extracellular vesicles (EVs). Since EVs carry a variety of cargoes of nucleic acids, lipids, and proteins and mediate intercellular communication, they have been the hotspot of diagnosis and treatment. The mechanisms underlying CNS disorders include angiogenesis, autophagy, apoptosis, cell death, and inflammation, and cell-EVs have been revealed to be involved in these pathological processes. Ischemic stroke is one of the most common causes of death and disability worldwide. It results in serious neurological and physical dysfunction and even leads to heavy economic and social burdens. Although a large number of researchers have reported that EVs derived from these cells play a vital role in regulating multiple pathological mechanisms in ischemic stroke, the specific interactional relationships and mechanisms between specific cell-EVs and stroke treatment have not been clearly described. This review aims to summarize the therapeutic effects and mechanisms of action of specific cell-EVs on ischemia. Additionally, this study emphasizes that these EVs are involved in stroke treatment by inhibiting and activating various signaling pathways such as ncRNAs, TGF-β1, and NF-κB.

show abstract

“…89 Exosomes can be internalized by adjacent or distant cells to regulate multiple target genes in recipient cells, they can participate in intercellular communication, and cell microenvironment interactions, and they can mediate cell signaling and metabolism. 94 The characteristics and dynamic changes of exosome cargo molecules directly reflect those of the parental tumor cells, 95 which constitutes the foundation for applying exosomes in cancer diagnosis and prognosis as well as for predicting an individual's response to antitumor therapy. 96 The Composition and Application of Exosomes in HCC…”

Section: Molecular Biological Characteristics Of Exosomesmentioning

confidence: 99%

The Application of Liquid Biopsy Techniques in High-Risk Population for Hepatocellular Carcinoma

Ding¹,

Zhao²

2022

CMAR

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system and has a 5-year overall survival rate of 14.1%. Many HCC patients are diagnosed at an advanced stage, and thus early screening is essential for reducing the mortality of HCC. In addition to commonly used detection indicators such as serum alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) and abnormal prothrombin (protein induced by vitamin K absence II, PIVKA-II), liquid biopsy techniques have been demonstrated to have diagnostic value in HCC detection. Compared with invasive procedures, liquid biopsy can detect circulatory metabolites of malignant neoplasms. Liquid biopsy techniques can detect circulating tumor cells, circulating tumor DNA, circulating RNA and exosomes and have been used in the early screening, diagnosis and prognostic evaluation of HCC. This paper reviews the molecular biological characteristics and application of different liquid biopsy techniques, and aim to highlight promising biomarkers that may be feasible options for early-stage HCC evaluation to improve early screening in populations at high risk for HCC.

show abstract

Extracellular Vesicles in Metabolism and Metabolic Diseases

Cited by 12 publications

References 94 publications

The Effect of Vitamin B17 on Cardiomyopathy against Ehrlich Tumor Development in Female Mice

The Effect of Vitamin B17 on Cardiomyopathy against Ehrlich Tumor Development in Female Mice

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

The Application of Liquid Biopsy Techniques in High-Risk Population for Hepatocellular Carcinoma

Contact Info

Product

Resources

About