Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Moghassemi, Saeid; Dadashzadeh, Arezoo; Sousa, Maria João; Vlieghe, Hanne; Yang, Jie; León-Félix, Cecibel María; Amorim, Christiani A.

doi:10.1016/j.bioactmat.2024.02.021

Cited by 8 publications

(3 citation statements)

References 459 publications

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“…Extracellular vesicles have been extensively studied as small membrane-bound vesicles released by cells into the extracellular environment. 33 They contain a range of biomolecules, including proteins, nucleic acids, and lipids, which typically range in diameter from 30–150 nanometres and are able to cross biological barriers such as the blood-brain barrier, making them promising vectors for drug delivery and disease diagnosis. 34 The unique composition and biocompatibility of NVs make it an attractive candidate for drug delivery systems and regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Mesenchymal Stem Cell-Derived Nanovesicles Containing H8 Improve Hepatic Glucose and Lipid Metabolism and Exert Ameliorative Effects in Type 2 Diabetes

Zhang,

Yuan,

Wang

et al. 2024

IJN

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Section: Discussionmentioning

confidence: 99%

Bone Marrow Mesenchymal Stem Cell-Derived Nanovesicles Containing H8 Improve Hepatic Glucose and Lipid Metabolism and Exert Ameliorative Effects in Type 2 Diabetes

Zhang,

Yuan,

Wang

et al. 2024

IJN

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“…Due to the similarity in structure and composition between the exosomal membrane and the cell membrane, recipient cells exhibit higher efficiency in uptaking exosomes compared to other nanocarriers. Additionally, surface proteins on the exosomal membrane can interact with surface receptors on cell membranes, directly activating signaling pathways in recipient cells and facilitating membrane fusion and internalization processes [ 161 ].…”

Section: Potential Applications Of Exosomes In Hepatitis Bmentioning

confidence: 99%

Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment

Wu,

Niu,

Shi

2024

J Nanobiotechnol

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Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its hepatotropism, the hepatitis B virus (HBV) cannot infect other cells. The mechanisms underlying the intercellular communication among different liver cells in HBV-infected individuals and the immune microenvironment imbalance remain elusive. Exosomes, as important intercellular communication and cargo transportation tools between HBV-infected hepatocytes and immune cells, have been shown to assist in HBV cargo transportation and regulate the immune microenvironment. However, the role of exosomes in hepatitis B has only gradually received attention in recent years. Minimal literature has systematically elaborated on the role of exosomes in reshaping the immune microenvironment of the liver. This review unfolds sequentially based on the biological processes of exosomes: exosomes’ biogenesis, release, transport, uptake by recipient cells, and their impact on recipient cells. We delineate how HBV influences the biogenesis of exosomes, utilizing exosomal covert transmission, and reshapes the hepatic immune microenvironment. And based on the characteristics and functions of exosomes, potential applications of exosomes in hepatitis B are summarized and predicted. Graphical Abstract

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“…Especially in tumor research, exosomes can be used as specific cancer biomarkers and diagnostic biomarkers for tumor diagnosis, treatment, efficacy assessment, and so on. 31 , 32 , 33 , 34 , 35 Similarly, studies have proved that exosomes play an important role as biomarkers in neurodegenerative diseases, 36 , 37 , 38 cardiovascular, 39 , 40 , 41 hepatic, 42 , 43 infectious diseases, 44 , 45 , 46 and autoimmune disease. 47 , 48 , 49 , 50 It is currently recognized as the most promising biomarker in the field of liquid biopsy.…”

Section: Introductionmentioning

confidence: 98%

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Xu,

Jiang,

et al. 2024

MedComm

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Exosomes are nanoscale vesicles of cellular origin. One of the main characteristics of exosomes is their ability to carry a wide range of biomolecules from their parental cells, which are important mediators of intercellular communication and play an important role in physiological and pathological processes. Exosomes have the advantages of biocompatibility, low immunogenicity, and wide biodistribution. As researchers’ understanding of exosomes has increased, various strategies have been proposed for their use in diagnosing and treating diseases. Here, we provide an overview of the biogenesis and composition of exosomes, describe the relationship between exosomes and disease progression, and focus on the use of exosomes as biomarkers for early screening, disease monitoring, and guiding therapy in refractory diseases such as tumors and neurodegenerative diseases. We also summarize the current applications of exosomes, especially engineered exosomes, for efficient drug delivery, targeted therapies, gene therapies, and immune vaccines. Finally, the current challenges and potential research directions for the clinical application of exosomes are also discussed. In conclusion, exosomes, as an emerging molecule that can be used in the diagnosis and treatment of diseases, combined with multidisciplinary innovative solutions, will play an important role in clinical applications.

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Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Cited by 8 publications

References 459 publications

Bone Marrow Mesenchymal Stem Cell-Derived Nanovesicles Containing H8 Improve Hepatic Glucose and Lipid Metabolism and Exert Ameliorative Effects in Type 2 Diabetes

Bone Marrow Mesenchymal Stem Cell-Derived Nanovesicles Containing H8 Improve Hepatic Glucose and Lipid Metabolism and Exert Ameliorative Effects in Type 2 Diabetes

Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

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