2019
DOI: 10.1016/j.cca.2019.09.002
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Extracellular vesicles in vascular calcification

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Cited by 42 publications
(40 citation statements)
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“…Collagen acts as a scaffold in controlling size and shape during this growth process [96]. However, in pathological environments (e.g., CKD (hyperphosphatemia), inflammation-driven atherosclerosis), VSMCs release extracellular vesicles, which contain more calcification-associated markers, and less calcification inhibitors [97]. In atherosclerotic plaques, collagen receptor-deficient VSMCs show increased release of calcified extracellular vesicles, and precipitation of collagen and minerals [97].…”
Section: Extracellular Vesiclesmentioning
confidence: 99%
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“…Collagen acts as a scaffold in controlling size and shape during this growth process [96]. However, in pathological environments (e.g., CKD (hyperphosphatemia), inflammation-driven atherosclerosis), VSMCs release extracellular vesicles, which contain more calcification-associated markers, and less calcification inhibitors [97]. In atherosclerotic plaques, collagen receptor-deficient VSMCs show increased release of calcified extracellular vesicles, and precipitation of collagen and minerals [97].…”
Section: Extracellular Vesiclesmentioning
confidence: 99%
“…However, in pathological environments (e.g., CKD (hyperphosphatemia), inflammation-driven atherosclerosis), VSMCs release extracellular vesicles, which contain more calcification-associated markers, and less calcification inhibitors [97]. In atherosclerotic plaques, collagen receptor-deficient VSMCs show increased release of calcified extracellular vesicles, and precipitation of collagen and minerals [97]. In this situation, transported proteins, in calcified EVs, possess the ability to uptake Ca 2+ and inhibit Fet-A activity [66].…”
Section: Extracellular Vesiclesmentioning
confidence: 99%
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“…However, the pathogenesis of atherosclerosis-related coronary calcification is complex and involves particularly extracellular calcification. Such calcification is initiated by extracellular microcalcification, which is promoted by calcification of microvesicles and exosomes secreted by VSMCs of synthetic phenotype typical of atherosclerotic lesions [182]. However, as indicated in Table 2, statins may also result in an increase of coronary Ca 2+ compared with other interventions [160,162,163,183].…”
Section: Therapeutic Aspectsmentioning
confidence: 99%
“…Exosomes are rich in biomolecules such as protein, mRNA and non-coding RNA such as miRNA, and have also emerged as both regulators and biomarkers of CVD progression [31]. For further information please refer to reviews [32][33][34][35][36][37].…”
Section: Microvesiclesmentioning
confidence: 99%