2023
DOI: 10.3390/biology12081138
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Extracellular Vesicles: Investigating the Pathophysiology of Diabetes-Associated Hypertension and Diabetic Nephropathy

Abstract: Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. EVs are released by all cell types and are found in biological fluids including plasma and urine. Urinary extracellular vesicles (uEVs) are a mixed population of EVs that comprise small EVs that are filtered and excreted, EVs secreted by tubular epithelial cells, and EVs released from the bladder, urethra, and prostate. The packaged cargo within uEVs includes bioactive molecules such as metabolites, lipids, proteins, mRNAs, and… Show more

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“…Extracellular vesicles (EVs) are nano-sized vesicles secreted by various cell types including renal epithelial cells. EVs have been shown to have beneficial roles and, in other cases, can contribute to pathophysiology [1]. These nano-sized vesicles carry various types of lipids, proteins, and nucleic acids from one cell to another to allow for intercellular communication [2,3] and intracellular signaling [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Extracellular vesicles (EVs) are nano-sized vesicles secreted by various cell types including renal epithelial cells. EVs have been shown to have beneficial roles and, in other cases, can contribute to pathophysiology [1]. These nano-sized vesicles carry various types of lipids, proteins, and nucleic acids from one cell to another to allow for intercellular communication [2,3] and intracellular signaling [4,5].…”
Section: Introductionmentioning
confidence: 99%