2024
DOI: 10.3390/cimb46040204
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Extracellular Vesicles Isolated from Equine Adipose-Derived Stromal Stem Cells (ASCs) Mitigate Tunicamycin-Induced ER Stress in Equine Corneal Stromal Stem Cells (CSSCs)

Justyna M. Meissner,
Aleksandra Chmielińska,
Ron Ofri
et al.

Abstract: Corneal ulcers, characterized by severe inflammation of the cornea, can lead to serious, debilitating complications and may be vision-threatening for horses. In this study, we aimed to investigate the role of endoplasmic reticulum (ER) stress in corneal stem progenitor cell (CSSC) dysfunction and explore the potential of equine adipose-derived stromal stem cell (ASC)-derived extracellular vesicles (EVs) to improve corneal wound healing. We showed that CSSCs expressed high levels of CD44, CD45, and CD90 surface… Show more

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“…The secreted factors can exert anti-inflammatory effects by regulating the activity of immune cells and reducing oxidative stress. Additionally, the secretome contains growth factors and cytokines that stimulate the proliferation and migration of corneal epithelial cells, facilitating reepithelialization [25][26][27]. Furthermore, the extracellular vesicles present in the secretome can transfer bioactive molecules, such as proteins, lipids, and nucleic acids, to target cells, influencing their behavior and promoting tissue repair [28,29].…”
Section: Discussionmentioning
confidence: 99%
“…The secreted factors can exert anti-inflammatory effects by regulating the activity of immune cells and reducing oxidative stress. Additionally, the secretome contains growth factors and cytokines that stimulate the proliferation and migration of corneal epithelial cells, facilitating reepithelialization [25][26][27]. Furthermore, the extracellular vesicles present in the secretome can transfer bioactive molecules, such as proteins, lipids, and nucleic acids, to target cells, influencing their behavior and promoting tissue repair [28,29].…”
Section: Discussionmentioning
confidence: 99%