2022
DOI: 10.1002/jev2.12221
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Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation

Abstract: Tumour‐associated angiogenesis plays a critical role in metastasis, the main cause of malignancy‐related death. Extracellular vesicles (EVs) can regulate angiogenesis to participate in tumour metastasis. Our previous study showed that EVs rich in HAX1 are associated with in metastasis of nasopharyngeal carcinoma (NPC). However, the mechanism by which HAX1 of EVs promotes metastasis and angiogenesis is unclear. In this study, we demonstrated that EVs rich in HAX1 promote angiogenesis phenotype by activating the… Show more

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Cited by 29 publications
(18 citation statements)
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“…Endothelial cell-specific expression of the FAK Y397F mutant reduces tumor angiogenesis ( Pedrosa et al, 2019 ), where FAK affects VEGFR2 transcription through its kinase activity ( Sun et al, 2018b ; Shiau et al, 2021 ). This has also been demonstrated in recent studies, where phosphorylated Try397-FAK was found to be an important part of angiogenesis promotion in experiments in which protrudin ( Arora et al, 2022 ) and HAX1 ( You et al, 2022 ) affected angiogenesis. Try397-FAK can affect angiogenesis via ERG ( D'Amico et al, 2022 ).…”
Section: Mechanism By Which Focal Adhesion Kinase Regulates Tumor Pro...supporting
confidence: 76%
“…Endothelial cell-specific expression of the FAK Y397F mutant reduces tumor angiogenesis ( Pedrosa et al, 2019 ), where FAK affects VEGFR2 transcription through its kinase activity ( Sun et al, 2018b ; Shiau et al, 2021 ). This has also been demonstrated in recent studies, where phosphorylated Try397-FAK was found to be an important part of angiogenesis promotion in experiments in which protrudin ( Arora et al, 2022 ) and HAX1 ( You et al, 2022 ) affected angiogenesis. Try397-FAK can affect angiogenesis via ERG ( D'Amico et al, 2022 ).…”
Section: Mechanism By Which Focal Adhesion Kinase Regulates Tumor Pro...supporting
confidence: 76%
“…Recently, You et al (You et al 2022) demonstrated, among other things, that HAX1 levels correlate with ribosome formation and that HAX1 promotes translation of the transcript encoding integrin subunit beta 6 in endothelial cells, which partially tallies with the findings presented here.…”
Section: Discussionsupporting
confidence: 89%
“…Previously, it was reported that HAX1 has an interaction with PELO, a protein involved in ribosomal rescue during ribosome stalling, but no mechanism for HAX1 involvement was proposed and no physiological effect was observed (Burnicka-Turek et al 2010). Recently, You et al (You et al 2022) demonstrated, among other things, that HAX1 levels correlate with ribosome formation and that HAX1 promotes translation of the transcript encoding integrin subunit beta 6 in endothelial cells, which partially tallies with the findings presented here.…”
Section: Discussionsupporting
confidence: 89%
“…NPC-EVs characterization and quantitation were determined by transmission electron microscope analysis and western blotting analysis as shown in our previous study [ 24 , 61 ].…”
Section: Methodsmentioning
confidence: 99%