2017
DOI: 10.3389/fmolb.2017.00050
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Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links

Abstract: The process of intercellular communication seems to have been a highly conserved evolutionary process. Higher eukaryotes use several means of intercellular communication to address both the changing physiological demands of the body and to fight against diseases. In recent years, there has been an increasing interest in understanding how cell-derived nanovesicles, known as extracellular vesicles (EVs), can function as normal paracrine mediators of intercellular communication, but can also elicit disease progre… Show more

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Cited by 104 publications
(91 citation statements)
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References 163 publications
(197 reference statements)
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“…Exosomes are small, 30-to 150-nm membrane vesicles that play a vital role in intercellular communication. [4][5][6][7] Tumor exosomes induce the activation and expansion of MDSCs, 8 and a recent study found that exosomes deliver noncoding RNAs, particularly microRNAs (miRNAs), 10 to recipient cells. 9 Interestingly, miRNAs play important roles in the expansion of functional MDSCs.…”
Section: Introductionmentioning
confidence: 99%
“…Exosomes are small, 30-to 150-nm membrane vesicles that play a vital role in intercellular communication. [4][5][6][7] Tumor exosomes induce the activation and expansion of MDSCs, 8 and a recent study found that exosomes deliver noncoding RNAs, particularly microRNAs (miRNAs), 10 to recipient cells. 9 Interestingly, miRNAs play important roles in the expansion of functional MDSCs.…”
Section: Introductionmentioning
confidence: 99%
“…Submicron structures are common in biology and can have various topologies. For example, submicron tubular structures are crucial for cellular communications 50 . They can usually not be studied with conventional fluorescence microscopes, the resolution of which is insufficient to differentiate, for instance, between stacked and hollow membrane tubes.…”
Section: Resolving Submicron Structures With Z-stedmentioning
confidence: 99%
“…TNTs are specialized filopodia that transport signals directly between cells. TNTs are composed of an actin core, although microtubules may also be involved in certain cell types [9]. Due to continuity of cytoplasm within the tube, larger cargo can be trafficked than could be shared via gap junctions [10][11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%