Extracorporeal blood purification is associated with improvement in biochemical and clinical variables in the critically‐ill <scp>COVID</scp>‐19 patients

Premužić, Vedran; Babel, Jakša; Gardijan, Danilo; Lapić, Ivana; Gabelica, Rajka; Ostojić, Zvonimir; Lozić, Marin; Pavliša, Gordana; Hrabak, Maja; Knežević, Josip; Rogić, Dunja; Mihaljević, Slobodan

doi:10.1111/1744-9987.13730

Cited by 22 publications

(20 citation statements)

References 30 publications

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“…With the aid of blood purification, the excess fluid could be efficiently eliminated to achieve negative volume balance. Consistently, current studies have also indicated the application of the absorbing filter Oxiris in moderate or severe or critically-ill COVID-19 patients with acute respiratory distress syndrome (ARDS), CSS or secondary infections (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 78%

Blood Purification in Severe and Critical COVID-19 Patients: A Case Series of 5 Patients

Chen

Zhang

et al. 2021

Front. Public Health

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Objective: The ongoing coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic. Currently, supportive care measures remain the standard of care for severe and critical COVID-19 patients, such as ventilation oxygenation, fluid management and blood purification. In this study, we aimed to evaluate the effects of early blood purification therapy upon severe and/or critical COVID-19 patients.Patients and Methods: From January 31, 2020 to March 1, 2020, a total 5 patients with COVID-19 (3 critical type cases and 2 severe type cases) received early blood purification treatment in the intensive care unit (ICU) of Affiliated Hospital of Zunyi Medical University. Clinical indexes, including oxygen concentration, blood gas analysis, oxygenation index, and laboratory test as well as disease scores were recorded and analyzed before and after the treatment with blood purification.Results: Among the 5 patients, 4 were males ranging from 35 to 80 year old (Mean age = 63 ± 17.87). All cases with characteristics of OI <300 mm Hg, decline in lymphocyte (LYMPH)%, boost in lactate dehydrogenase (LDH), troponin T (TNT), B-type brain natriuretic peptide (BNP), interleukin-6 (IL-6) and interferon-alpha (IFN-a), three with high flow nasal cannula (HFNC), two with non-invasive ventilation (NIV) and acute kidney injury (AKI), and one with shock and IV. Blood purification therapy significantly decreased the serum levels of inflammatory cytokine, ameliorated the concomitant symptoms and complications. Finally, one case was discharged from the hospital, 4 cases were transferred to the general ward, and all the 5 cases survived.Conclusion: Continuous blood purification therapy held promising prospects for alleviating the deteriorative progression of severe and critical types of COVID-19 in the early stage, together with ameliorating the accumulation of inflammatory cytokine and the concomitant symptoms and complications by efficacious immunoadsorption.Trial Registration:www.chictr.org.cn, Identifier (ChiCTR2000031930).

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Section: Discussionmentioning

confidence: 78%

Blood Purification in Severe and Critical COVID-19 Patients: A Case Series of 5 Patients

Chen

Zhang

et al. 2021

Front. Public Health

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“…Biosky MG350 has a blood flow of 400 mL/min with an operating time of 2 h depending on the mode of operation. Compared to other adsorbers, Biosky MG350 requires a long rinsing procedure (Table 4 [ 84 - 88 ]).…”

Section: Extracorporeal Therapy In Sepsismentioning

confidence: 99%

Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements

Mehta¹,

Paul²,

Ansari³

et al. 2023

World J Crit Care Med

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BACKGROUND Despite various therapies to treat sepsis, it is one of the leading causes of mortality in the intensive care unit patients globally. Knowledge about the pathophysiology of sepsis has sparked interest in extracorporeal therapies (ECT) which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory mediators. AIM To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical outcomes. METHODS In this review, an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis. A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only abstracts. RESULTS Results showed that ECT techniques such as high-volume hemofiltration, coupled plasma adsorption/filtration, resin or polymer adsorbers, and CytoSorb ® are emerging as adjunct therapies to improve hemodynamic stability in sepsis. CytoSorb ® has the most published data in regard to the use in the field of septic shock with reports on improved survival rates and lowered sequential organ failure assessment scores, lactate levels, total leucocyte count, platelet count, interleukin- IL-6, IL-10, and TNF levels. CONCLUSION Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical trials. In addition to patient-tailored therapies, future research developments with therapies targeting the cellular level of the immune response are expected.

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“…Extracorporeal therapies were studied as potential treatment for the removal of cytokines in patients with sepsis. Therefore, they are potentially considered to prevent cytokine release syndrome‐induced organ damage in critically ill patients with COVID‐19 [146].…”

Section: Acute Kidney Injurymentioning

confidence: 99%

Kidneys in SARS‐CoV‐2 era: A challenge of multiple faces

et al. 2022

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Introduction: With the evolution of SARS-CoV-2 pandemic, it was believed to be a direct respiratory virus. But, its deleterious effects were observed on different body systems, including kidneys. Aim of Work: In this review, we tried as much as we can to summarize what has been discussed in the literature about the relation between SARS-CoV-2 infection and kidneys since December, 2019.Methods: Each part of the review was assigned to one or two authors to search for relevant articles in three databases (Pubmed, Scopus, and Google scholar) and collected data were summarized and revised by two independent researchers. Conclusion:The complexity of COVID-19 pandemic and kidney could be attributed to the direct effect of SARS-CoV-2 infection on the kidneys, different clinical presentation, difficulties confronting dialysis patients, restrictions of the organ transplant programs, poor outcomes and bad prognosis in patients with known history of kidney diseases who got infected with SARS-CoV-2.

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Extracorporeal blood purification is associated with improvement in biochemical and clinical variables in the critically‐ill COVID‐19 patients

Cited by 22 publications

References 30 publications

Blood Purification in Severe and Critical COVID-19 Patients: A Case Series of 5 Patients

Blood Purification in Severe and Critical COVID-19 Patients: A Case Series of 5 Patients

Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements

Kidneys in SARS‐CoV‐2 era: A challenge of multiple faces

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