Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010–2011 winter seasonal outbreak of influenza A (H1N1) in Spain

Bonastre, Juan; Suberviola, Borja; Pozo, Juan C.; Guerrero, José Eugenio; Torres, Alberto; Rodríguez, A.; Martín‐Loeches, Ignacio

doi:10.1016/j.medine.2012.05.001

Cited by 15 publications

(16 citation statements)

References 25 publications

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“…In patients with respiratory failure from H1N1 infection who required the use of ECMO, the survival rate varied considerably between studies ranging from 35 to 90% [15][16][17][18][19][20][21][22][23][24][25][26][27][28]. There was a large variation in survival rates, which could be explained by differences in patients' baseline characteristics and severity of illness.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

Alshahrani

Sindi

Alshamsi

et al. 2018

Ann. Intensive Care

166

181

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BackgroundMiddle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy in severely hypoxemic patients who failed conventional strategies.MethodsWe collected data retrospectively on MERS-CoV patients with refractory respiratory failure from April 2014 to December 2015 in 5 intensive care units (ICUs) in Saudi Arabia. Patients were classified into two groups: ECMO versus conventional therapy. Our primary outcome was in-hospital mortality; secondary outcomes included ICU and hospital length of stay.ResultsThirty-five patients were included; 17 received ECMO and 18 received conventional therapy. Both groups had similar baseline characteristics. The ECMO group had lower in-hospital mortality (65 vs. 100%, P = 0.02), longer ICU stay (median 25 vs. 8 days, respectively, P < 0.01), and similar hospital stay (median 41 vs. 31 days, P = 0.421). In addition, patients in the ECMO group had better PaO2/FiO2 at days 7 and 14 of admission to the ICU (124 vs. 63, and 138 vs. 36, P < 0.05), and less use of norepinephrine at days 1 and 14 (29 vs. 80%; and 36 vs. 93%, P < 0.05).ConclusionsECMO use, as a rescue therapy, was associated with lower mortality in MERS patients with refractory hypoxemia. The results of this, largest to date, support the use of ECMO as a rescue therapy in patients with severe MERS-CoV.

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Section: Discussionmentioning

confidence: 99%

Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

Alshahrani

Sindi

Alshamsi

et al. 2018

Ann. Intensive Care

166

181

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“…The recent experience in 2009 using ECMO for pandemic influenza A (H1N1)-associated acute respiratory distress syndrome (ARDS) revealed that many centers initiated ECMO programs without significant experience and with variable results (7,(9)(10)(11)(12)(13)(14)(15)(16). Because ECMO is a complex, high-risk, and costly modality, at present it should be conducted in centers with sufficient experience, volume, and expertise to ensure it is used safely.…”

mentioning

confidence: 99%

Position Paper for the Organization of Extracorporeal Membrane Oxygenation Programs for Acute Respiratory Failure in Adult Patients

Combes

Brodie

Bartlett

et al. 2014

Am J Respir Crit Care Med

426

324

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The use of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory failure (ARF) in adults is growing rapidly given recent advances in technology, even though there is controversy regarding the evidence justifying its use. Because ECMO is a complex, high-risk, and costly modality, at present it should be conducted in centers with sufficient experience, volume, and expertise to ensure it is used safely. This position paper represents the consensus opinion of an international group of physicians and associated health-care workers who have expertise in therapeutic modalities used in the treatment of patients with severe ARF, with a focus on ECMO. The aim of this paper is to provide physicians, ECMO center directors and coordinators, hospital directors, health-care organizations, and regional, national, and international policy makers a description of the optimal approach to organizing ECMO programs for ARF in adult patients. Importantly, this will help ensure that ECMO is delivered safely and proficiently, such that future observational and randomized clinical trials assessing this technique may be performed by experienced centers under homogeneous and optimal conditions. Given the need for further evidence, we encourage restraint in the widespread use of ECMO until we have a better appreciation for both the potential clinical applications and the optimal techniques for performing ECMO.

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“…Mortality rates ranged from 14 to 64% in the 16 studies from 11 countries reporting on the experience of ECMO for influenza A(H1N1)-associated ARDS (Tables 4 and 5) [15][16][17]33,[37][38][39][40][41][42][43][44][45][46][47][48]. The Australia and New Zealand collaborative group (ANZICS) was the first to report its experience [15].…”

Section: Results Of Ecmo For Pandemic Influenza a (H1n1)-associated Ardsmentioning

confidence: 99%

Extracorporeal Gas Exchange for Acute Respiratory Failure in Adult Patients: A Systematic Review

Schmidt

Hodgson

2015

Annual Update in Intensive Care and Emergency Medicine

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Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010–2011 winter seasonal outbreak of influenza A (H1N1) in Spain

Cited by 15 publications

References 25 publications

Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

Position Paper for the Organization of Extracorporeal Membrane Oxygenation Programs for Acute Respiratory Failure in Adult Patients

Extracorporeal Gas Exchange for Acute Respiratory Failure in Adult Patients: A Systematic Review

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