Angiotensin receptor blockers are commonly used to treat hypertension. However, the toxicity of this medication can be life-threatening and can cause severe hypotension and refractory shock. There are no case reports or published guidelines for its management. We hereby present a case of a young female with telmisartan overdose who was managed with multiple vasopressors and rescue therapies like methylene blue, high-dose glucose-insulin infusion, ascorbic acid, thiamine, steroids, and other agents. Early detection and intensive management of refractory shock are necessary to prevent mortality.