Extracorporeal membrane oxygenation for support of children after hematopoietic stem cell transplantation: the Extracorporeal Life Support Organization experience

Gow, Kenneth W.; Wulkan, Mark L.; Heiss, Kurt F.; Haight, Ann E.; Heard, Micheal; Rycus, Peter; Fortenberry, James D.

doi:10.1016/j.jpedsurg.2005.12.006

Cited by 63 publications

(71 citation statements)

References 45 publications

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“…Most clinical studies of ECMO have either been based on mixed groups of patients with various types of solid tumors or on pediatric patients [12][13][14]. Earlier studies The survival distribution of the two groups was compared using a log-rank test.…”

Section: Discussionmentioning

confidence: 99%

“…In these patients, the development of organ failure is a predictor of mortality [12]. The APACHE II score is used to predict mortality in critically ill patients with hematologic malignancies [9].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these were clinical studies involving either a mixture of patients with various types of solid tumors or pediatric patients, and the successful use of the technique in both settings was rare [12][13][14]. The present study provides a systematic assessment of the clinical outcomes of patients with hematologic malignancies who were treated with ECMO after the failure of optimal conventional therapy, based on a retrospective review of the patients' medical records.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Outcomes of Extracorporeal Membrane Oxygenation Support for Patients With Hematologic Malignancies

Kang

Lim²,

Lee³

et al. 2014

Chest

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Outcomes of Extracorporeal Membrane Oxygenation Support for Patients With Hematologic Malignancies

Kang

Lim²,

Lee³

et al. 2014

Chest

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“…3 Similarly, mortality following bone-marrow transplantation (a particularly immunodeficient population) was extremely high: only 1 of 19 patients treated with ECMO survived to hospital discharge in a review of the Extracorporeal Life Support Organization database from 1991 to 2004. 7 However, another well recognized cause of immunodeficiency is malignancy, and ECMO use is becoming more prevalent in that patient population. Gow et al 8 found, in a series of 86 patients with various malignancies and treated with ECMO, that survival to hospital discharge was better (35%) than in other immunodeficient patients.…”

Section: Ecmo In Immunodeficiencymentioning

confidence: 99%

Successful Extracorporeal Membrane Oxygenation for Respiratory Failure in an Infant With DiGeorge Anomaly, Following Thymus Transplantation

Hornik

Hartman²,

Markert³

et al. 2011

Respir Care

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We report the first successful use of venovenous extracorporeal membrane oxygenation (ECMO) for refractory respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation. A 23-month-old female with complete immune-incompetent DiGeorge anomaly 65 days after allogenic thymus transplantation was treated in our pediatric intensive care unit for acute respiratory failure secondary to bacterial sepsis. She subsequently developed acute hypercarbic respiratory failure unresponsive to conventional medical therapy. She was successfully managed with venovenous ECMO for 4 days, with complete resolution of her respiratory symptoms. This case demonstrates the complex decision making process regarding initiation of ECMO in patients with severe immunodeficiency.

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“…These findings might be due to improved management of ARDS, like prone positioning [6] and therapy with extracorporeal membrane oxygenation (ECMO) [7,8]. There are some experiences with ECMO treatment in paediatric oncologic patients [9,10,11] and 2 small studies on ECMO treatment in adult haematologic patients [2,12]. However, the data on adult cancer patients receiving ECMO are very limited.…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation in Predominantly Leuco- and Thrombocytopenic Haematologic/Oncologic Patients with Acute Respiratory Distress Syndrome - a Single-Centre Experience

et al. 2018

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Aims: The acute respiratory distress syndrome (ARDS) is a frequent condition following pneumonia in immunocompromised cancer patients. Extracorporeal membrane oxygenation (ECMO) may serve as a rescue therapy in refractory ARDS but has still not been studied in predominantly leuco- and thrombocytopenic cancer patients. Patients and Methods: In this monocentric, retrospective, observational study, we assessed all cancer patients treated with ECMO for ARDS between 2013 and 2017. Results: 25 patients, 11 of whom underwent haematopoietic stem cell transplantation (SCT), were analysed. The main reason for ARDS was pneumonia in 72%. All patients were under invasive ventilation at ECMO. All but 9/3 patients suffered from leuco-/thrombocytopenia due to anti-cancer treatment or underlying disease. Overall, 17 patients (68%) died on ECMO, whereas 5 patients survived to hospital discharge (20%). All patients after recent allogeneic (allo-)SCT have died. 4 patients experienced severe bleeding events. Conclusions: Discouraging survival rates in patients treated after allo-SCT do not support the use of ECMO for ARDS in this patient subgroup. On the contrary, cancer patients in at least stable disease otherwise eligible for full-code intensive care unit management, even those with severe thrombocytopenia, may be potential candidates for ECMO in case of severe ARDS failing conventional measures.

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Extracorporeal membrane oxygenation for support of children after hematopoietic stem cell transplantation: the Extracorporeal Life Support Organization experience

Cited by 63 publications

References 45 publications

Clinical Outcomes of Extracorporeal Membrane Oxygenation Support for Patients With Hematologic Malignancies

Clinical Outcomes of Extracorporeal Membrane Oxygenation Support for Patients With Hematologic Malignancies

Successful Extracorporeal Membrane Oxygenation for Respiratory Failure in an Infant With DiGeorge Anomaly, Following Thymus Transplantation

Extracorporeal Membrane Oxygenation in Predominantly Leuco- and Thrombocytopenic Haematologic/Oncologic Patients with Acute Respiratory Distress Syndrome - a Single-Centre Experience

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