Extracorporeal Membrane Oxygenation in Pediatric Liver Transplantation: A Multicenter Linked Database Analysis and Systematic Review of the Literature

Abstract

The data reported here have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the US Government.

Emergency living donor liver transplantation under extracorporeal membrane oxygenation in an infant with biliary atresia-polysplenia syndrome

“…In the present patient, sudden occurrence of pulmonary hemorrhage led to acute respiratory distress syndrome, warranting veno-venous ECMO to enhance oxygenation before LDLT [9,10]. ECMO was continued for 17 days until recovery of oxygenation through ventilator support.…”

“…BAPS is regarded as a high-risk factor for LT because of technical difficulties associated with anomaly in LT operation and frequent posttransplant vascular complications [4][5][6][7][8]. Extracorporeal membrane oxygenation (ECMO) is a form of life support used for patients with life-threatening heart and/or lung problems [9][10][11]. We present a case of emergency living donor liver transplantation (LDLT) using a left lateral section graft successfully performed in a 10-month-old patient with BAPS under ECMO.…”

Peri-operative extracorporeal membrane oxygenation in adult and pediatric living donor liver transplantation: a single-center experience

“…The more commonly reported causes of peri-operative cardiovascular failure in LT include reperfusion-associated right ventricular failure, intra-cardiac thrombosis, and massive pulmonary embolism ( 6 ). In our study, three patients suffered from cardiogenic shock leading to initiation of ECMO.…”

“…Prior to the utilization of extracorporeal membrane oxygenation (ECMO) in LT, the aforementioned conditions carried a very high mortality rate ( 2 ). Though initial reports showed dismal prognosis despite utilization of ECMO, technological innovations and accumulation of experience have resulted in better survival rates ( 6 ). ECMO is a potential rescue therapy for severe cardiopulmonary failure following LT for both adult and pediatric recipients with survival rates ranging from 28.6% to 68.2% ( 4 - 6 ).…”

“…Though initial reports showed dismal prognosis despite utilization of ECMO, technological innovations and accumulation of experience have resulted in better survival rates ( 6 ). ECMO is a potential rescue therapy for severe cardiopulmonary failure following LT for both adult and pediatric recipients with survival rates ranging from 28.6% to 68.2% ( 4 - 6 ). To date, a few studies have examined the role and outcome of ECMO in LT and due to the rarity of its use, the majority of these studies are case reports, case series and center-linked database analysis ( 4 - 9 ) ( Table S1 ).…”