Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Failure. A Randomized Prospective Study

Zapol, Warren M.; Snider, Michael T.; Hill, J. Donald; Fallat, Robert J.; Bartlett, Robert H.; Edmunds, L. Henry; Morris, Alan H.; Peirce, E. Converse; Thomas, Arthur N.; Proctor, H. J.; Drinker, Philip; Pratt, Philip C.; Bagniewski, A.; Miller, Rod

doi:10.1097/00132586-198012000-00016

Cited by 205 publications

(250 citation statements)

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“…Several reports have shown a higher survival rate in ARDS patients treated with extracorporeal support [4,5]. However, randomized controlled trials have failed to demonstrate that ECMO improves outcome in ARDS [6,7]. Therefore, the indication of ECMO for ARDS is controversial.…”

Section: Discussionmentioning

confidence: 99%

Successful extracorporeal membranous oxygenation for a patient with life-threatening transfusion-related acute lung injury

et al. 2009

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A case of transfusion-related acute lung injury (TRALI) that was successfully treated with extracorporeal membranous oxygenation (ECMO) is reported. A 58-year-old male patient underwent hepatectomy, and pulmonary edema occurred after the administration of fresh-frozen plasma and packed red cells. In the postoperative period, the impaired oxygenation progressively worsened, resulting in life-threatening hypoxemia, despite vigorous treatments. ECMO was therefore applied to the patient as a method of safe emergency support. Aggressive treatments under ECMO led to the successful improvement of the impaired oxygenation. TRALI is recognized as part of acute respiratory distress syndrome (ARDS). As a treatment for ARDS, ECMO does not cure the underlying disease of the lungs, however, with ECMO, TRALI, usually improves within 96 h with respiratory support. ECMO for TRALI-induced lethal hypoxemia is useful for providing time to allow the injured lung to recover. It is suggested that ECMO might be a useful option for the treatment of TRALI-induced, potentially lethal hypoxemia.

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Section: Discussionmentioning

confidence: 99%

Successful extracorporeal membranous oxygenation for a patient with life-threatening transfusion-related acute lung injury

et al. 2009

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“…ECMO involves oxygenation of the patient's blood outside the body via a membrane oxygenator which acts as an artificial lung, allowing adequate gaseous exchange without vigorous mechanical ventilation. An earlier study conducted in the 1970s showed no survival benefit, with overall mortality exceeding >90% 68. A UK clinical trial (CESAR) randomised eligible patients with ARDS to ‘conventional’ treatment in the referring centre or transfer to the specialist centre for ECMO.…”

Section: Treatmentmentioning

confidence: 99%

Acute respiratory distress syndrome and acute lung injury

Dushianthan

Grocott

Postle

et al. 2011

Postgraduate Medical Journal

263

187

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Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases. Despite

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“…Due to negative outcomes reported by previous studies, ECMO has been considered to be a contraindication for patients waiting for future lung transplantation. [1,2] However, developments in techniques and devices have not only enabled patients to benefit from ECMO, but also have led to decreases in the risk of bleeding and lung injury from prolonged mechanical ventilation. [3] Accordingly, the role of ECMO as a bridge to lung transplantation has garnered greater interest in the field of transplantation, especially for ventilation-refractory patients.…”

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confidence: 99%

One Hundred Seven Days of ECMO as a Bridge to Lung Transplantation: The Longest Duration Among Elderly Patients

Kim

Paik

Park

et al. 2014

Korean J Crit Care Med

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Extracorporeal membrane oxygenation (ECMO) is a means for supporting adequate gas exchange in patients with severe respiratory failure and is the only therapeutic option for ventilation-refractory patients awaiting lung transplantation. Moreover, defining the patients likely to benefit from ECMO as a bridge to transplantation has recently become a point of interest. Here, we report a case of prolonged ECMO support to a patient awaiting lung transplantation. A 66-year-old woman was diagnosed with acute interstitial pneumonia and was placed on veno-venous (VV) ECMO due to unsatisfactory gas exchange despite maximal ventilator care. She underwent bilateral lung transplantation after 99 days of ECMO and was successfully weaned from it on the 107th ECMO day. This is the longest period of ECMO support to be reported among elderly patients.

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Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Failure. A Randomized Prospective Study

Cited by 205 publications

References 0 publications

Successful extracorporeal membranous oxygenation for a patient with life-threatening transfusion-related acute lung injury

Successful extracorporeal membranous oxygenation for a patient with life-threatening transfusion-related acute lung injury

Acute respiratory distress syndrome and acute lung injury

One Hundred Seven Days of ECMO as a Bridge to Lung Transplantation: The Longest Duration Among Elderly Patients

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