Extracorporeal photopheresis in chronic graft-versus-host disease: clinical description and economic study

Vargas, Dora Fraga; Pereira, Mariana Pinto; Silva, Tatiana Schnorr; David, Caroline Nespolo de; Paz, Alessandra Aparecida; Astigarraga, Cláudia Cáceres

doi:10.1016/j.htct.2021.08.014

Cited by 1 publication

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…While uncommon, grave clinical manifestations of chronic GVHD may comprise polyserositis, characterized by pleural and pericardial effusions, and polymyositis, characterized by serious weaknesses in muscles and raised levels of muscle enzymes. 24 , 25 …”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…This process leads to the cross-linking of pyrimidine bases in Deoxy Ribonucleic Acid (DNA), resulting in significant mortality of the treated (patient) cells. 1 , 14 , 24 …”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…This is due to its efficacy exceeding 80% and substantial enhancement in chronic GVHD with sclerosis. 13 , 24 , 32 …”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…22,23 Chronic GVHD may develop in up to 50% of patients, and in moderate to severe cases, systemic immunosuppressive therapy is necessary for individuals who are undergoing allogeneic HSCT. 1,22,24 Individuals who have survived allogeneic HSCT for more than two years face the risk of non-relapse-related illness and death, with chronic being the predominant cause. Even as procedures for transplantation improve, there is a potential https://doi.org/10.2147/ITT.S457366…”

Section: Destruction Of the Target Tissues By Effector T Cellsmentioning

confidence: 99%

See 4 more Smart Citations

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Berhan,

Damtie,

Almaw

et al. 2024

ITT

View full text Add to dashboard Cite

Hematopoietic stem cell donation is a method used to treat both blood-related and non-blood-related malignancies. Graft-versus-host disease is a potentially life-threatening complication that can occur following a stem cell transplant from a donor. This happens after the transplanted grafts attack the recipient’s body as foreign cells, causing significant morbidity and mortality. Clinically, this condition can be classified as acute or chronic based on onset and pathophysiology. This review aims to provide an overview of recent studies on extracorporeal photopheresis as a treatment strategy option for graft-versus-host-diseased patients. It will explain how it treats graft-versus-host disease, summarize its promising effects, and provide future recommendations for its use in treating this illness. Extracorporeal photopheresis is used to treat graft-versus-host disease by collecting and separating white blood cells from the patient. This blood is fractionated into different parts, and white blood cells undergo treatment with 8-methoxy psoralen, a photoactivable drug, before exposure to ultraviolet light A. Lastly, the cells that have been treated are reinfused into the recipient’s body. It prompts the programmed cell death of lymphocytes and the engulfment of cellular debris by host antigen-presenting, leading to a subsequent rise in T regulatory cells. However, more experimental and randomized controlled studies are required to identify the best patient selection requirements, environments, and treatment regimens for graft-versus-host disease.

show abstract

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…This process leads to the cross-linking of pyrimidine bases in Deoxy Ribonucleic Acid (DNA), resulting in significant mortality of the treated (patient) cells. 1 , 14 , 24 …”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…This is due to its efficacy exceeding 80% and substantial enhancement in chronic GVHD with sclerosis. 13 , 24 , 32 …”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

Section: Destruction Of the Target Tissues By Effector T Cellsmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Berhan,

Damtie,

Almaw

et al. 2024

ITT

View full text Add to dashboard Cite

show abstract

Extracorporeal photopheresis in chronic graft-versus-host disease: clinical description and economic study

Cited by 1 publication

References 28 publications

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Contact Info

Product

Resources

About