Extracorporeal photopheresis in the treatment of acute graft-versus-host disease: A multicenter experience

Batgi, Hikmetullah; Dal, Mehmet Sinan; Erkurt, Mehmet Ali; Kuku, İrfan; Kurtoğlu, Erdal; Hindilerden, İpek Yönal; Kaya, Emin; Berber, İlhami; Ulaş, Turgay; Altuntaş, Fevzi

doi:10.1016/j.transci.2021.103242

Cited by 7 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Twenty-seven (36%) patients survived and 48 (64%) patients died. 13 The final result of the study, in the univariate Cox regression analysis, the degree of aGVHD, the duration of ECP administration after aGVHD, and the duration of steroid use were found to be significant. Patients with lower grades (≤2) according to CM results had a significantly longer survival.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Effect of extracorporeal photopheresis on survival in acute graft versus host disease

Kaya

Erkurt

Kuku

et al. 2023

J of Clinical Apheresis

Self Cite

View full text Add to dashboard Cite

BackgroundExtracorporeal photopheresis (ECP) is the main non‐pharmacological approach accompanying systemic medical treatments in steroid‐resistant acute or chronic graft versus host disease. The study aimed to examine the effect of ECP on survival in acute graft versus host disease (aGVHD).MethodsA total of 35 patients who were followed up in the adult hematology clinic of İnönü University Turgut Özal Medical Center for aGVHD were included in the study. Stem cell transplantation and ECP application parameters that may affect the survival of the patients were examined.ResultsIn aGVHD using ECP, the degree of involvement affects survival. Involvements with a clinical and laboratory score (Glucksberg system) of 2 and above significantly reduced survival. The duration of ECP use is associated with survival. Especially, 45 days and longer use increases survival (hazard ratio, P‐value <.05). The duration of steroid use was found to be effective in survival in aGVHD (P < .001). ECP administration day (P = .003), duration of steroid use (P < .001), duration of ECP use (P = .001), and grade of aGVHD (P < .001) affect survival.ConclusionECP use is effective in survival in patients with aGVHD score ≥2. In patients with aGVHD, especially the use of 45 days and longer has a positive effect on survival. The duration of steroid use is associated with survival in aGVHD.

show abstract

Section: Discussionmentioning

confidence: 90%

“…Median follow‐up was 6 months; median overall survival was 5 months for nonresponders and 68 months for responders. Twenty‐seven (36%) patients survived and 48 (64%) patients died 13 …”

Section: Discussionmentioning

confidence: 99%

Effect of extracorporeal photopheresis on survival in acute graft versus host disease

Kaya

Erkurt

Kuku

et al. 2023

J of Clinical Apheresis

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to these considerations, ECP is regarded as an immunomodulatory treatment rather than an immunosuppressive therapy. [30][31][32] The therapy was developed as an alternative for those individuals who showed unresponsiveness to their primary treatment options. It is a leukapheresis-based therapy.…”

Section: Role Of Photopheresis In the Management Of Gvhd Overview Abo...mentioning

confidence: 99%

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Berhan,

Damtie,

Almaw

et al. 2024

ITT

View full text Add to dashboard Cite

Hematopoietic stem cell donation is a method used to treat both blood-related and non-blood-related malignancies. Graft-versus-host disease is a potentially life-threatening complication that can occur following a stem cell transplant from a donor. This happens after the transplanted grafts attack the recipient’s body as foreign cells, causing significant morbidity and mortality. Clinically, this condition can be classified as acute or chronic based on onset and pathophysiology. This review aims to provide an overview of recent studies on extracorporeal photopheresis as a treatment strategy option for graft-versus-host-diseased patients. It will explain how it treats graft-versus-host disease, summarize its promising effects, and provide future recommendations for its use in treating this illness. Extracorporeal photopheresis is used to treat graft-versus-host disease by collecting and separating white blood cells from the patient. This blood is fractionated into different parts, and white blood cells undergo treatment with 8-methoxy psoralen, a photoactivable drug, before exposure to ultraviolet light A. Lastly, the cells that have been treated are reinfused into the recipient’s body. It prompts the programmed cell death of lymphocytes and the engulfment of cellular debris by host antigen-presenting, leading to a subsequent rise in T regulatory cells. However, more experimental and randomized controlled studies are required to identify the best patient selection requirements, environments, and treatment regimens for graft-versus-host disease.

show abstract

“…La fotoresis extracorpórea (FEC) es una terapia inmunomoduladora atractiva que evita la inmunosupresión generalizada, siendo este el tratamiento de segunda línea refractario a esteroides. Es por esto que la FEC consiste en infundir linfocitos irradiados con radiación ultravioleta e incubarlos con 8 -metoxipsoraleno, para regular los clones de células T activos y aumentar las células T reguladoras; aunque el número de estudios publicados es limitado, se demuestra eficacia 17,18 .…”

Section: Tratamiento De Eichunclassified

Pacientes con enfermedad injerto contra huésped e infecciones asociadas al rechazo de trasplante

Jaramillo¹

2023

cysa

View full text Add to dashboard Cite

Introducción: durante muchos años las células madre hematopoyéticas han sido el tratamiento para muchos trastornos hematológicos, pero su eficacia está limitada por la enfermedad injerto contra huésped (EICH); una de las principales complicaciones del trasplante alogénico se encuentra asociado con morbilidad y mortalidad, por lo tanto, la prevención es importante para el éxito del trasplante alogénico. Objetivo: realizar una revisión acerca del reconocimiento clínico de una EICH para brindar el tratamiento correcto y evitar ciertas complicaciones, como infecciones que llevan al rechazo del injerto y ponen en riesgo la calidad de vida del paciente. En la mayoría de los casos las pruebas de laboratorio como biomarcadores y biopsias, son buenos predictores para procesos biológicos o patológicos que confirmen el diagnóstico y establezcan el estadio de la enfermedad. Metodología: se realizó una revisión bibliográfica en bases de datos, tales como Pubmed y ClinicalKey, con base en los siguientes términos MeSH: cirugía, mortalidad, patología, complicaciones, virología. Conclusión: la prevención y tratamiento de esta enfermedad predispone a infecciones y diferentes complicaciones que ponen en riesgo la vida del paciente.

show abstract

Extracorporeal photopheresis in the treatment of acute graft-versus-host disease: A multicenter experience

Cited by 7 publications

References 24 publications

Effect of extracorporeal photopheresis on survival in acute graft versus host disease

Effect of extracorporeal photopheresis on survival in acute graft versus host disease

The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Pacientes con enfermedad injerto contra huésped e infecciones asociadas al rechazo de trasplante

Contact Info

Product

Resources

About