This case study evaluates the use of Extracorporeal Pulse Activation Therapy (EPAT) and Amniotic Extracellular Matrix Injection (AEMI) in a patient suffering unilateral post-traumatic subtalar joint (STJ) osteoarthritis. Following an injury he was not able to work or exercise secondary to subtalar joint pain. He had failed treatment with bracing, physical therapy, and PRP injections and was not interested in surgery. Following serial EPAT and AEMI the patient had a decrease in pain score (from 5/10 at rest, to 2/10 with activity and 0/10 at rest) and was able to return to work and activities. In conclusion, EPAT and AEMI are effective treatments for STJ arthritis, present a viable alternative to surgery, and should be explored for use in other degenerative conditions of the foot and ankle.