Extracorporeal shock wave therapy for delayed union of long bone fractures-Preliminary results of a prospective cohort study

Beutler, Sascha S.; Regel, G.; Pape, Hans‐Christian; Machtens, S.; Weinberg, Annelie M.; Kremeike, I.; Jonas, U.; Tscherne, H

doi:10.1097/00005131-200001000-00020

Cited by 5 publications

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“…19,20 It is important to remember that the level of applied energy was often given merely as the charge voltage of the shock-wave device and that the morphological observations were correlated with this value. [21][22][23] The charge voltage of the shock-wave device, however, gives no information about the amount of energy measurable in the focus zone of shock waves, which is responsible for the biological effects of ESWA. 24 As a result, contradictory findings in the literature of the effects of ESWA on bone may be due to different energy levels and are therefore difficult to interpret.…”

Section: Discussionmentioning

confidence: 99%

Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo

Maier¹,

Milz²,

Tischer³

et al. 2002

The Journal of Bone and Joint Surgery. British volume

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Section: Discussionmentioning

confidence: 99%

Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo

Maier¹,

Milz²,

Tischer³

et al. 2002

The Journal of Bone and Joint Surgery. British volume

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“…3 is indicated as an alternative, non-invasive but promising method for treatment of bone fractures, effective even in delayed fracture healing or nonunion (1)(2)(3)(4)(5)(6). The cure rate of the above disorders after ESW therapy has been reported to be 75-91% (7).…”

Section: Extracorporeal Shock Wave (Esw)mentioning

confidence: 99%

Optimal Intensity Shock Wave Promotes the Adhesion and Migration of Rat Osteoblasts via Integrin β1-mediated Expression of Phosphorylated Focal Adhesion Kinase

Chen

et al. 2012

Journal of Biological Chemistry

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Background:The effects of extracorporeal shock wave (ESW) on adhesion and migration of osteoblasts have not been reported until now. Results: Optimal intensity shock wave promotes osteoblast adhesion and migration. Conclusion: ESW promotes the adhesion and migration of osteoblasts via integrin ␤1-mediated expression of phosphorylated FAK.Significance: This provides a mechanistic basis for improving the effectiveness of ESW treatment in fracture healing and tissue engineering.

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“…Extracorporeal shock-wave (ESW) therapy has been shown to have a promising effect on the treatment of tendinopathies and the healing of fractures. [1][2][3][4][5] Experimental studies on cell lines or vessels have indicated that ESW can cause damage. 6,7 Haupt et al 8 first identified that ESW could enhance osteogenic activity, but the mechanism by which it promotes bone healing in fractures remains to be determined.…”

mentioning

confidence: 99%

Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1

Wang¹,

Yang²,

Chen³

et al. 2002

The Journal of Bone and Joint Surgery. British volume

112

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E xtracorporeal shock-wave (ESW) treatment has been shown to be effective in promoting the healing of fractures. We aimed to determine whether ESW could enhance the growth of bone-marrow osteoprogenitor cells. We applied ESW to the left femur of rats 10 mm above the knee at 0.16 mJ/mm 2 in a range of between 250 and 2000 impulses. Bone-marrow cells were harvested after ESW for one day and subjected to assessment of colony-forming unit (CFU) granulocytes, monocytes, erythocytes, megakaryocytes (CFU-Mix), CFU-stromal cells (CFU-S) and CFU-osteoprogenitors (CFU-O).We found that the mean value for the CFU-O colonies after treatment with 500 impulses of ESW was 168.2 CFU-O/well (SEM 11.3) compared with 88.2 CFU-O/well (SEM 7.2) in the control group. By contrast, ESW treatment did not affect haematopoiesis as shown by the CFU-Mix (p = 0.557). Treatment with 250 and 500 impulses promoted CFU-O, but not CFU-Mix formations whereas treatment with more than 750 impulses had an inhibiting effect. Treatment with 500 impulses also enhanced the activity of bone alkaline phosphatase in the subculture of CFU-O (p<0.01), indicating a selective promotion of growth of osteoprogenitor cells. Similarly, formation of bone nodules in the long-term culture of bone-marrow osteoprogenitor cells was also significantly enhanced by ESW treatment with 500 impulses. The mean production of TGF-␤1 was 610 pg/ml (SEM 84.6) in culture supernatants from ESW-treated rats compared with 283 pg/ml (SEM 36.8) in the control group.Our findings suggest that optimal treatment with ESW could enhance rat bone-marrow stromal growth and differentiation towards osteoprogenitors presumably by induction of TGF-␤1.

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Extracorporeal shock wave therapy for delayed union of long bone fractures-Preliminary results of a prospective cohort study

Cited by 5 publications

References 0 publications

Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo

Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo

Optimal Intensity Shock Wave Promotes the Adhesion and Migration of Rat Osteoblasts via Integrin β1-mediated Expression of Phosphorylated Focal Adhesion Kinase

Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1

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