Extracorporeal Shock Wave Therapy for Management of Chronic Ulcers in the Lower Extremities

Saggini, Raoul; Figus, Andrea; Troccola, Antonietta; Cocco, V. Garcia; Saggini, Andrea; Scuderi, Nicolò

doi:10.1016/j.ultrasmedbio.2008.01.010

Cited by 105 publications

(111 citation statements)

References 58 publications

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“…Recently, several studies are reported that showed the beneficial effects of low-energy SW therapy in other disorders, including skin flap model in rodents (Stojadinovic et al 2008;Yan et al 2008) and patients with refractory chronic skin ulcers (Saggini et al 2008;Moretti et al 2009). Also, low to high energy levels of SW is widely used for the treatment of certain orthopedic conditions, such as nonunions, tendinosis calcarea, epicondylitis and calcaneal spur (Birnbaum et al 2002;Wang et al 2003).…”

Section: Sw Therapy For Other Disordersmentioning

confidence: 99%

Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy

Ito

Shimokawa

2009

Tohoku J. Exp. Med.

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Section: Sw Therapy For Other Disordersmentioning

confidence: 99%

Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy

Ito

Shimokawa

2009

Tohoku J. Exp. Med.

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“…In addition to the accelerated healing rates in patients treated with ESWT, this therapeutic approach is noninvasive and cost-effective. Despite the growing evidence of the beneficial clinical effects of ESWT in treating musculoskeletal disorders and soft tissue wounds in animal models and clinical studies (3)(4)(5)(6)(7)(8)(9)(10), the underlying mechanisms of how ESWT exerts these beneficial effects have remained unclear.…”

mentioning

confidence: 99%

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Weihs

Fuchs

Teuschl

et al. 2014

Journal of Biological Chemistry

143

124

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Background: Signaling pathways underlying beneficial effects of extracorporeal shock wave treatment (ESWT) remain to be completely elucidated. Results: ESWT enhances cell proliferation in vitro and wound healing in vivo. Conclusion: ESWT-induced ATP release and subsequent extracellular signal-regulated kinase (ERK) activation are prerequisites for enhanced cell proliferation and wound healing. Significance: Deciphering the involved signaling cascades provides the basis for ESWT as clinical wound healing treatment.

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“…Initially, high-energy ESW was used to fragmentize urinary stones. Recently, low-energy ESW was shown to be beneficial in the treatment of various chronic wounds, including bedsores, burn wounds, diabetic and vascular ulcers (Meirer et al 2005;Schaden et al 2007;Saggini et al 2008;Larking et al 2010;Wolff et al 2011). Clinical studies demonstrated that low-energy ESW treatment (ESWT) accelerated the healing of chronic diabetic foot ulcers and displayed no treatment-related toxicity, infection, or deterioration of wounds (Moretti et al 2009).…”

mentioning

confidence: 99%

Extracorporeal Shock Wave Treatment Improves Incisional Wound Healing in Diabetic Rats

Yang

Luo

Yan

et al. 2011

Tohoku J. Exp. Med.

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Impaired wound healing in surgical patients with diabetes increases the incidence of infection, prolongs hospitalization, and even increases the rate of mortality. Low-energy extracorporeal shock wave treatment (ESWT) was reported to accelerate chronic wound healing by promoting revascularization and tissue regeneration; however, it is not known if ESWT could also improve healing of acute surgical incisional wounds in diabetes. In this study, using a rat model of diabetes, we investigated the effect of low-energy ESWT on collagen content in wound tissues and its efficacy in incisional wound healing. A single dorsal incisional wound was inflicted in streptozotocin-induced diabetic rats, and they received ESWT at different time post-wounding. Rats were sacrificed on days 7 and 14 post-wounding. Wound breaking strength, hydroxyproline content, histological characteristics and the expression of transforming growth factor beta 1 (TGF-β1) were analyzed. As a result, the wound breaking strength was significantly enhanced and the hydroxyproline content in wound tissues was increased at each time point examined. The number of fibroblasts was significantly increased, and the new collagen fibers were more abundant at the wound site after ESWT. Furthermore, the expression of TGF-β1 was up-regulated after ESWT on day 7 post-wounding. These results suggest that low-energy ESWT can increase collagen content, enhance wound breaking strength and improve the healing of incisional wound in diabetic rats. The increased collagen content may be attributed, at least in part, to the up-regulation of TGF-β1 expression in wound tissues.

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Extracorporeal Shock Wave Therapy for Management of Chronic Ulcers in the Lower Extremities

Cited by 105 publications

References 58 publications

Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy

Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Extracorporeal Shock Wave Treatment Improves Incisional Wound Healing in Diabetic Rats

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