Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis

Zhao, Zhe; Ji, Hui-Ru; Ru-fang, Jing; Liu, Chunmei; Wang, Ming-Bo; Zhai, Ling; Bai, Xiaodong; Xing, Gengyan

doi:10.1007/s00402-012-1586-4

Cited by 57 publications

(49 citation statements)

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“…Prior studies reported that ESWT has chondroprotective effects in ACLT-induced OA knee in rats [20-22]. Zhao and his colleagues [22] reported that ESWT reduces the progression of knee OA in rabbits by reducing the nitric oxide level and chondrocyte apoptosis.…”

Section: Discussionmentioning

confidence: 99%

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Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals

et al. 2014

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IntroductionThis study investigated the effectiveness of extracorporeal shockwave therapy (ESWT) in osteoporotic (OP) osteoarthritis (OA) of rat knee.MethodsFifty-six rats were divided into seven groups including sham, OA, OP, OA + OP, OA + ESWT, OP + ESWT, and OA + OP + ESWT groups. The evaluations included gross pathology, bone mineral density (BMD), micro-computed tomography (micro-CT) scan, bone-strength test, histopathologic examination, and immunohistochemical analysis.ResultsOn gross pathology, group OA + OP showed larger areas of osteoarthritic changes than did groups OA and OP, as compared with the sham group. BMD and bone strength significantly decreased in groups OA, OP, and OA + OP relative to the sham group, and ESWT significantly improved BMD and bone-strength changes. On micro-CT scan, the subchondral plate thickness significantly decreased, and the bone porosity increased in groups OA, OP, and OA + OP, and ESWT significantly improved the changes in subchondral-plate thickness and bone porosity. In histopathologic examination, Mankin score and safranin O score significantly increased in groups OA and group OA + OP, but not in group OP relative to the sham group, and ESWT significantly improved the changes. In immunohistochemical analysis, Dickkopf-1 (DKK-1) significantly increased, but vessel endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), and bone morphogenetic protein 2 (BMP-2) decreased in groups OA, OP, and OA + OP relative to the sham group, and ESWT significantly reversed the changes.ConclusionsOsteoporosis increased the severity of cartilage damage in osteoarthritis of the knee. ESWT showed effectiveness in the reduction of osteoporotic osteoarthritis of the knee in rats.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies demonstrated that application of ESWT to subchondral bone of the proximal tibia shows a chondroprotective effect in the initiation of OA of the knee and induces regression of established OA of the knee in rats [20-22]. ESWT was noted to have multifunctional effects in bone and cartilage.…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals

et al. 2014

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“…Although proliferative effects were indicated, some studies have reported no significant effects but some of the recent animal experiments have indicated that ESWT application has chondroprotective effects and relieves symptoms such as pain by improving motor functions (21-24). Zhao et al (25) suggested that these effects were due to the inhibition of nitric oxide (NO) release and partial apopytosis. Mayer-Wagner et al (26) reported that ESWT down-regulates Tenascin-C whose expression increases at the superficial layer of the joint cartilage in OA.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of extracorporeal shockwave therapy and lowintensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial

et al. 2017

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Objective: This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees.Material and Methods: Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0.09% saline solution was delivered to the left knees in group 1 for control. Twenty-four hours after the delivery, ESWT was applied once on the right knees in the group 2 rats to the medial tibia plateu with a 1 Hz frequency and 800 impulses. LIPUS was applied to the right knees in the group 2 rats to the medial tibia plateu with a 3 mHz frequency and 40 mW/cm2 intensity for 20 minutes over a period of 15 days. Pain scores were measured with a knee bend test. Bone mineral density measurements and scintigraphic bone scans were performed. Histopathological examination was done using a modified Mankin scale.Results: There was no difference among the right knee subchondral bone osteoblastic activities (p>0.05). The left knee osteoblastic activities in the LIPUS and extracorporeal shockwave therapy (ESWT) groups were higher than those in the control group (p<0.05), but there was no difference between the LIPUS and ESWT groups. There was no difference among the groups for both knee subchondral bone BMD values (p>0.05). The modified Mankin scores of both the right and left knees of the ESWT and LIPUS groups were lower than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. The pain scores of both knees of the ESWT and LIPUS groups at day 7 were higher than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. There was no difference among the pain scores of the right knees at day 14 (p<0.05).Conclusion: ESWT and LIPUS have systemic proliferative and regenerative effects on cartilage and tissue.

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“…Положительное действие ударной волны на соединительнотканные структуры, костную, мышечную и хрящевую ткани [41][42][43][44][45][46][47][48] [50].…”

Section: виды реабилитационной помощи при па-тологиях суставовunclassified

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2016

JCMK

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The article provides literature review that reflect a modern view on the problem of articular pathology treatment and rehabilitation.Step-by-step osteoarthritis management schemes, published in the leading recommendations (NICE, OARSI, HKOA) are presented. The results of modern clinical trials, systematic reviews and meta-analyzes on the use of various methods of physical therapy for joints diseases treatment from the standpoint of evidence-based medicine are analyzed. Etiopathogenetic and clinical substantiation for inclusion of physiotherapy measures in rehabilitation programs were given to help maximizing the impact on all links of the pathological process chain.The use of different methods and techniques of physical therapy for osteoarthritis is currently debated, because of the contradictory literature data. Low level of evidence does not allow including physical therapy in the leading guidelines of osteoarthritis management. The reasons for low level of evidence might be small samples and insufficient degree of randomization in the majority of studies. Different sensitivity of patients to physical therapy and presence of associated diseases necessitate individualization of rehabilitation program that makes further large-scale assessment of impact of the physical factors difficult.However, considering physical therapy infinite possibilities, scientists continue to actively explore, constantly improve and implement a lot of new, highly effective methods of physiotherapy in rehabilitation process of osteoarthritis, proving the prospects of this type of conservative therapy.Keywords: osteoarthritis -physiotherapy -rehabilitation. J Clin Med Kaz 2016; 2(40):6-13Автор для корреспонденции: Минбаева Лариса Сергеевна, Карагандинский государственный медицинский университет. Адрес: г. Караганда, ул. Ержа-нова, 53-42. Тел.: +77053142637. E-mail: minbayeva_larissa@mail.ru.Буын пАтологиясы реАБилитАциясының мәселелеріне зАмАнуи көзқАрАс Шевелева н.и., минбаева л.с.Қарағанды мемелекеттік медицина университеті, медициналық реабилитология және дене тәрбиесі кафедрасы, Қарағанды, Қазахстан ТұжырымдамаМақалада буын патологиясының реабилитациясы және емдеу мәселеріне замануи көзқарастың көрінісінің, әдебиеттік шолудың мәліметтері көрсетілген.Остеоартроз менеджменті бойынша (NICE, OARSI, HKOA) жетекші нұсқауларда көрсетілген терапияның кезекті үлгісі жарықта көрсетілген. Дәлелді медицина ұстанынымен буын сырқаттарын емдеу үшін физиотерапияның әр түрлі үлгісін, үлгілі шолу және мета-анализді қолданумен замануи клиникалық зерттеулердің қорытындылары келтірілген. Патологиялық үдірістің барлық буындарына мейлінше тиімді әсер беру үшін, қалпына келтіру бағдарламасына физиотерапия құралын қосу үшін клиникалық және этиопатогенетикалық негіздеме берілген.Әдебиетте көрсетілген мағлұматтар қарама қайшы болғандықтан, остеоартроз кезінде әр түрлі физиотерапия үлгісін және әдісін қолдану қазіргі уақытта пікірталас тудырады. Дәлелдік деңгейдің төменділігі, остеоартрит менеджменті бойынша жетекші басшылыққа фи-зиотерапияны қосуға мүм...

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Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis

Abstract: ESWT reduced the progression of OA in rabbits. This effect may be related to decreased level of NO and is likely mediated by reduced chondrocyte apoptosis. ESWT may be a useful treatment for knee OA.

Cited by 57 publications

References 23 publications

Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals

Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals

Efficacy of extracorporeal shockwave therapy and lowintensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial

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