2021
DOI: 10.1080/15563650.2020.1870123
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Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup

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Cited by 23 publications
(22 citation statements)
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“…Finally, the preparation of albumin dialysate is labor-intensive and costly. 23 , 24 The optimal concentration of albumin necessary to achieve benefit while limiting unnecessary excess albumin is currently unknown. Churchwell et al showed a relationship between the albumin concentration and the clearance of valproic acid and carbamazepine, but not phenytoin.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, the preparation of albumin dialysate is labor-intensive and costly. 23 , 24 The optimal concentration of albumin necessary to achieve benefit while limiting unnecessary excess albumin is currently unknown. Churchwell et al showed a relationship between the albumin concentration and the clearance of valproic acid and carbamazepine, but not phenytoin.…”
Section: Discussionmentioning
confidence: 99%
“…Haemodialysis and haemofiltration are ineffective modes of therapy due to the large volume of CCBs distribution (5.5 l/ kg for verapamil) and their predilection to bind to plasma proteins [3]. Although the use of extracorporeal treatments has been suggested, the work group recommend against this method in CCBs poisoning [34]. Lipid emulsion therapy (LET) involves the intravenous injection of lipid emulsion, which creates lipid phase within the blood and binds to lipidsoluble drugs, thus reducing their volume of distribution.…”
Section: Discussionmentioning
confidence: 99%
“…Eğer kalsiyum kanalları tamamen kalsiyum kanal blokerleriyle (verapamil, diltiazem) doyurulmuşsa L tipi kanallarda %100'e yakın kapalı olacaktır ve yüksek plazma kalsiyum seviyesi kardiyak fonksiyonları arttırmayacaktır. Kalsiyum infüzyonu kusmaya, akut ritm bozuklukları (özellikle hızlı verildiğinde, asistole kadar varan) ve lokal irritasyona neden olabileceğinden infüzyon esnasında komplikasyonlar açısından dikkatli olunmalıdır (3,4,(6)(7)(8)10,13,17). Glukagon: Kalsiyum infüzyonuna klinik cevap yetersiz ise hastanın hipotansiyonu devam ediyorsa tedaviye glukagon eklenmelidir.…”
Section: Antidotlar Kalsiyumunclassified