2020
DOI: 10.1111/jon.12777
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Extracranial Carotid Artery Stenosis: The Effects on Brain and Cognition with a Focus on Resting‐State Functional Connectivity

Abstract: Extracranial carotid artery stenosis (ECAS) due to the presence of atherosclerotic plaque is a well-known risk factor for stroke. Several structural imaging studies have investigated the effect of ECAS on the brain, focusing on structural damage (in particular cerebral small vessel disease) and on the rearrangement of the cerebral circulation. For example, it is known from the literature an association between carotid stenosis and cerebral small vessel disease, and it is also noted that a series of compensator… Show more

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Cited by 13 publications
(17 citation statements)
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References 103 publications
(222 reference statements)
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“…Carotid plaque and carotid stenosis reflect different stages of carotid atherosclerosis. A recent review of the effects of carotid stenosis on the brain and cognition (Porcu et al, 2020) summarized the disrupted functional connectivity and cognitive impairment in patients with carotid stenosis (Wang and Xiao, 2017;Gao et al, 2019). Many studies have reported that the cerebrovascular system activates a series of compensatory mechanisms to overcome the cerebral hypoperfusion that is induced by carotid stenosis (Shakur et al, 2014;Zarrinkoob et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
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“…Carotid plaque and carotid stenosis reflect different stages of carotid atherosclerosis. A recent review of the effects of carotid stenosis on the brain and cognition (Porcu et al, 2020) summarized the disrupted functional connectivity and cognitive impairment in patients with carotid stenosis (Wang and Xiao, 2017;Gao et al, 2019). Many studies have reported that the cerebrovascular system activates a series of compensatory mechanisms to overcome the cerebral hypoperfusion that is induced by carotid stenosis (Shakur et al, 2014;Zarrinkoob et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Previous imaging studies have investigated the effects of carotid stenosis on the brain, focusing on structural damage and functional connectivity (Porcu et al, 2020). Asymptomatic carotid stenosis has been shown to have a detrimental effect on neuronal activity and regional functional connections (Rocque et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Rao et al (36) compared the different neuropsychological approaches and found that findings were too contrasting and inhomogeneous to be correctly interpreted and compared. In general, the findings about this topic, underline an impact on general cognitive functions and some more involvement of memory, attention, and executive functions but without a specific domain compromise (34,36,54,61).…”
Section: Possible Pathogenetic Mechanismsmentioning
confidence: 92%
“…Recently, several studies showed, with the use of MRI or digital subtraction angiography, the relevance of collateral circles in preserving cognitive functions in patients with carotid stenosis (34). In the presence of a failure of the collateral vessels system, blood flow derangement occurs and it can induce a worsening of cerebral functions, including cognitive activities.…”
Section: Possible Pathogenetic Mechanismsmentioning
confidence: 99%
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