Extracranial germ cell tumours in children and adolescents: Results from the French TGM13 protocol

Faure‐Conter, Cécile; Orbach, Daniel; Sudour-Bonnange, Hélène; Vérité, Cécile; Mansuy, L; Rome, Angélique; Dumesnil, C.; Thébaud, Estelle; Renard, Marleen; Hameury, F.; Fléchon, Aude; Blanc, Ellen; Dijoud, Frédérique; Fresneau, Brice; Chabaud, Sylvie

doi:10.1002/pbc.30117

Cited by 1 publication

(1 citation statement)

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“…According to the French TGM 95 study conducted by Freseneau et al, the predicted time to normalization of AFP did not have significant prognostic value [61]. On the other hand, a study by Faure-Conter et al on the TGM13-NS protocol, which aimed to achieve high cure rates with minimized chemotherapy doses in children with GCT, demonstrated that AFP normalization had a prognostic impact on EFS (HR = 1.003 [1000-1007]) [62]. O'Neill et al, analyzing data from the Children's Oncology Group (COG) AGCT0132 protocol, showed that children who had a satisfactory decrease in AFP (with normalization of any of the first two measurements more than 7 days after starting chemotherapy or an AFP half-life of ≤7 days) had a lower cumulative 3-year recurrence rate compared to those with an unsatisfactory decrease (11 vs. 38%) [63].…”

Section: Germ Cell Tumorsmentioning

confidence: 99%

Role of Alpha-Fetoprotein (AFP) in Diagnosing Childhood Cancers and Genetic-Related Chronic Diseases

Głowska-Ciemny,

Szymanski,

Kuszerska

et al. 2023

Cancers

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Alpha-fetoprotein (AFP) is a protein commonly found during fetal development, but its role extends beyond birth. Throughout the first year of life, AFP levels can remain high, which can potentially mask various conditions from the neurological, metabolic, hematological, endocrine, and early childhood cancer groups. Although AFP reference values and clinical utility have been established in adults, evaluating AFP levels in children during the diagnostic process, treatment, and post-treatment surveillance is still associated with numerous diagnostic pitfalls. These challenges arise from the presence of physiologically elevated AFP levels, inconsistent data obtained from different laboratory tests, and the limited population of children with oncologic diseases that have been studied. To address these issues, it is essential to establish updated reference ranges for AFP in this specific age group. A population-based study involving a statistically representative group of patients could serve as a valuable solution for this purpose.

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Section: Germ Cell Tumorsmentioning

confidence: 99%