Extracranial Hypothermia During Cardiac Arrest and Cardiopulmonary Resuscitation Is Neuroprotective <i>In Vivo</i>

Hutchens, Michael P.; Fujiyoshi, T.; Koerner, Ines P.; Herson, Paco S.

doi:10.1089/ther.2014.0003

Cited by 9 publications

(4 citation statements)

References 59 publications

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“…The 2010 AHA Guidelines for CPR strongly recommended to monitor the quality of the CPR and identify ROSC, and indeed P ET CO 2 has more clinical operability than CPP. Although the optimal target for P ET CO 2 during CPR had not been established[ 21 ], a value of less than 10mmHg had been associated with a failure to achieve ROSC and might indicate that the quality of chest compressions should be improved[ 22 ]. Studies also showed that P ET CO 2 directly correlated with cardiac output in the cardiac arrest patient[ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Pulse Oximetry: A Non-Invasive, Novel Marker for the Quality of Chest Compressions in Porcine Models of Cardiac Arrest

Zheng

et al. 2015

PLoS ONE

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ObjectivePulse oximetry, which noninvasively detects the blood flow of peripheral tissue, has achieved widespread clinical use. We have noticed that the better the quality of cardiopulmonary resuscitation (CPR), the better the appearance of pulse oximetry plethysmographic waveform (POP). We investigated whether the area under the curve (AUC) and/or the amplitude (Amp) of POP could be used to monitor the quality of CPR.DesignProspective, randomized controlled study.SettingAnimal experimental center in Peking Union Medical Collage Hospital, Beijing, China.SubjectsHealthy 3-month-old male domestic swine.Interventions34 local pigs were enrolled in this study. After 4 minutes of untreated ventricular fibrillation, animals were randomly assigned into two resuscitation groups: a “low quality” group (with a compression depth of 3cm) and a “high quality” group (with a depth of 5cm). All treatments between the two groups were identical except for the depth of chest compressions. Hemodynamic parameters [coronary perfusion pressure (CPP), partial pressure of end-tidal carbon dioxide (PETCO2)] as well as AUC and Amp of POP were all collected and analyzed.Measurements and FindingsThere were statistical differences between the “high quality” group and the “low quality” group in AUC, Amp, CPP and PETCO2 during CPR (P<0.05). AUC, Amp and CPP were positively correlated with PETCO2, respectively (P<0.01). There was no statistical difference between the heart rate calculated according to the POP (FCPR) and the frequency of mechanical CPR at the 3rd minute of CPR. The F CPR was lower than the frequency of mechanical CPR at the 6th and the 9th minute of CPR.ConclusionsBoth the AUC and Amp of POP correlated well with CPP and PETCO2 in animal models. The frequency of POP closely matched the CPR heart rate. AUC and Amp of POP might be potential noninvasive quality monitoring markers for CPR.

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Section: Discussionmentioning

confidence: 99%

Pulse Oximetry: A Non-Invasive, Novel Marker for the Quality of Chest Compressions in Porcine Models of Cardiac Arrest

Zheng

et al. 2015

PLoS ONE

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“…Previous studies have demonstrated the sensitivity and accuracy of utilizing brain‐body temperature differences for detecting disease processes (e.g., cardiac arrest, 47 stroke 48 ). Body temperatures, which were not collected in the present study, could therefore be helpful for establishing the reproducibility of whole‐brain temperature mapping.…”

Section: Limitationsmentioning

confidence: 99%

Reproducibility of whole‐brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopy

et al. 2020

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Assessing brain temperature can provide important information about disease processes (e.g., stroke, trauma) and therapeutic effects (e.g., cerebral hypothermia treatment). Whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) is increasingly used to quantify brain metabolites across the entire brain. However, its feasibility and reliability for estimating brain temperature needs further validation.Therefore, the present study evaluates the reproducibility of WB-MRSI for temperature mapping as well as metabolite quantification across the whole brain in healthy volunteers. Ten healthy adults were scanned on three occasions 1 week apart. Brain temperature, along with four commonly assessed brain metabolites-total N-acetylaspartate (tNAA), total creatine (tCr), total choline (tCho) and myo-inositol (mI)-were measured from WB-MRSI data. Reproducibility was evaluated using the coefficient of variation (CV). The measured mean (range) of the intra-subject CVs was 0.9% (0.6%-1.6%) for brain temperature mapping, and 4.7% (2.5%-15.7%), 6.4%(2.4%-18.9%) and 14.2% (4.4%-52.6%) for tNAA, tCho and mI, respectively, with reference to tCr. Consistently larger variability was found when using H 2 O as the reference for metabolite quantifications: 7.8% (3.3%-17.8%), 7.8% (3.1%-18.0%), 9.8% (3.7%-31.0%) and 17.0% (5.9%-54.0%) for tNAA, tCr, tCho and mI, respectively. Further, the larger the brain region (indicated by a greater number of voxels within that region), the better the reproducibility for both temperature and metabolite estimates. Our results demonstrate good reproducibility of whole-brain temperature and metabolite measurements using the WB-MRSI technique. K E Y W O R D Sbrain temperature, magnetic resonance spectroscopy, reproducibility, whole-brain magnetic resonance spectroscopy Abbreviations used: 1 H-MRS, proton magnetic resonance spectroscopy; CRLB, Cramer-Rao lower bound; CV, coefficient of variation; EPSI, echo-planar spectroscopic imaging; FOV, field of view; mI, myo-inositol; MIDAS, Metabolic Imaging and Data Analysis System; MINT, Map INTegrated; ROI, region of interest; SVS, single voxel spectroscopy; tCho, total choline; tCr, total creatine; tNAA, total N-acetyl-aspartate; WB-MRSI, whole-brain magnetic resonance spectroscopic imaging.

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“…CA/CPR and sham procedure. Eight-minute normothermic CA/CPR leading to AKI has previously been described by our group and was conducted identically to prior experiments (10,(42)(43)(44)(45). Following induction of anesthesia with isoflurane, mice (male C57BL/6, 8-12 weeks old, n = 16) were orotracheally intubated with a 22-gauge catheter.…”

Section: Methodsmentioning

confidence: 99%

Glomerular filtrate proteins in acute cardiorenal syndrome

Wakasaki¹,

Matsushita²,

Golgotiu³

et al. 2019

JCI Insight

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Extracranial Hypothermia During Cardiac Arrest and Cardiopulmonary Resuscitation Is Neuroprotective In Vivo

Cited by 9 publications

References 59 publications

Pulse Oximetry: A Non-Invasive, Novel Marker for the Quality of Chest Compressions in Porcine Models of Cardiac Arrest

Pulse Oximetry: A Non-Invasive, Novel Marker for the Quality of Chest Compressions in Porcine Models of Cardiac Arrest

Reproducibility of whole‐brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopy

Glomerular filtrate proteins in acute cardiorenal syndrome

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