Extracranial Skeletal Metastasis in Anaplastic Oligodendroglioma: Case Report and Review of the Literature

Wu, Yan; Liu, B; Qu, Limei; Tao, H

doi:10.1177/147323001103900331

Cited by 11 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall survival ranged from 3–288 months, with a median of 38 months. These data are consistent with the recent reports of AOs [57,63]. The survival time of our patient was relatively shorter than the median, although he was given the standard regimen recommended by the National Comprehensive Cancer Net (NCCN) guidelines [73].…”

Section: Discussionsupporting

confidence: 92%

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

Zhang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

BackgroundIt is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.MethodsWe described in detail the clinical story of one patient with anaplastic OGD, which metastasized to lymph nodes, bone marrowand bones Genetic analyses included detection of 1p and 19q chromosomal arms, methylation status of MGMT promoter, and PTEN exon mutations. A search of worldwide literature was conducted for reports of metastatic OGDs using NCBI-PubMed, with the keywords “extracranial”, “extraneural”, “oligodendroglioma”, “oligodendrogliomas”, “metastatic”, “metastasis”, and “metastases”, in different combinations.ResultsAn open biopsy of the infiltrated bones in our patient revealed that malignant cells had replaced the patient’s marrow. Moreover, the diagnosis of multiple-organ metastases of anaplastic OGD was confirmed based on immunohistochemical staining. Genetic analyses showed that the tumors originated from previously resected brain lesions. None of the lesions had 1p and 19q deletions, but hypermethylation of MGMT promoter, and the G → A transversion at codon 234 of PTEN exon 2 were detected. Literatures review yielded 60 reports of metastatic OGDs from 1951 to the present, which with our patient makes 61 cases. Concerning these 61 patients, there were 110 infiltrated sites correlated closely with primary OGDs. The most frequent metastatic sites were bone and bone marrow (n = 47; 42.7%), lymph nodes (n = 22; 20.0%), liver (n = 7; 6.4%), scalp (n = 6; 5.5%), lung (n = 6; 5.5%), pleura (n = 4; 3.6%), chest wall (n = 3; 2.7%), iliopsoas muscle (n = 2; 1.8%), soft tissue (n = 2; 1.8%), and parotid gland (n = 2; 1.8%).ConclusionsExtracranial metastases in anaplastic OGD are very rare but they do occur; bone and bone marrow may be the most common sites. Detection of certain molecular markers such as deletion of 1p and 19q chromosomal arms, hypermethylation of MGMT promoter, and characteristic PTEN exon mutations may help differentiate subtypes which are more prone to extracranial metastases.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8749838611478560.

show abstract

Section: Discussionsupporting

confidence: 92%

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

Zhang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

show abstract

“…After initial MRI diagnosis of a brainstem mass lesion, staging was declined by the owner. While staging should always be offered before treatment, metastasis of primary brain tumours is rarely reported in dogs 22 . Gemistocytic astrocytomas metastasis in people has been reported in 1.01% of affected patients 23 .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic imaging, treatment and outcome in a 14‐month‐old Dobermann with brainstem gemistocytic astrocytoma

Manzanedo‐Delgado¹,

Mason²,

Pumarola

et al. 2021

Vet Record Case Reports

View full text Add to dashboard Cite

A 14-month-old male neutered Dobermann presented for investigations into lingual paresis, dysphagia and proprioceptive ataxia of the pelvic limbs. Magnetic resonance imaging (MRI) revealed a mass lesion in the brainstem. Treatment with glucocorticoids and radiation therapy (RT) achieved a good quality of life for 6 months, after which deterioration occurred. Repeated MRI revealed an expansion of the mass lesion, after which the owners elected for the patient to be euthanised. Postmortem histological examination and immunohistochemistry confirmed the presence of a gemistocytic astrocytoma. This case report describes the first case in the veterinary literature of a young dog with a brainstem gemistocytic astrocytoma treated with RT and glucocorticoids, with remission of clinical signs and excellent quality of life for 6 months after treatment.

show abstract

“…17,27,28,30 Lungs and lymph nodes are the most involved sites with distant metastasis from primary CNS tumors suggesting hematogenous and lymphogeneous pathways of dissemination.…”

Section: Discussionmentioning

confidence: 99%

Osteosclerosis Secondary to Metastatic Oligodendroglioma

et al. 2016

View full text Add to dashboard Cite

This paper reviews a case of metastatic 1p/19q codeleted oligodendrioglioma causing diffuse osteosclerosis and pain. Primary central nervous system (CNS) tumors rarely metastasize outside the CNS, and metastatic oligodendroglioma is rarer still. The patient in this study had relief of pain after being treated with temozolomide. We discuss this rare presentation and potential treatment options, and review the literature in regards to metastatic oligodendrogliomas.

show abstract

Extracranial Skeletal Metastasis in Anaplastic Oligodendroglioma: Case Report and Review of the Literature

Abstract: A case of anaplastic oligodendroglioma with femoral metastasis is presented in a 37-year old male with a 2-year history of progressive headaches and dizziness associated with a 2-month history of epilepsy and right hemiparesis.

Cited by 11 publications

References 40 publications

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

Diagnostic imaging, treatment and outcome in a 14‐month‐old Dobermann with brainstem gemistocytic astrocytoma

Osteosclerosis Secondary to Metastatic Oligodendroglioma

Contact Info

Product

Resources

About