Extract identification and evaluation of the cytotoxic activity of Polygala fallax Hemsl in Heilongjiang ethnic medicine against tumors

Yang, Guang; Lang, Yan

doi:10.3233/thc-236050

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Recently, the extracts of P. fallax Hemsl. (Polygalaceae) were reported to be used for the treatment of endometriosis [35], perimenopausal syndrome [36], diabetic nephropathy [3], and tumors [37]. Previous studies have focused on the effects of total saponins, flavones, and flavones in P. fallax Hemsl.…”

Section: Compounds Extractive Fractions Referencementioning

confidence: 99%

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Research Progress on the Medicinal and Edible Polygala fallax Hemsl. (Polygalaceae) Plant

et al. 2023

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Polygala fallax Hemsl., a species belonging to the genus Polygala and the family Polygalaceae, is primarily distributed in southern China. Wild P. fallax Hemsl. (Polygalaceae) is currently endangered, but its utilization value has not yet been thoroughly investigated. The present review summarizes the morphological and structural characteristics, wild resource distribution, chemical constituents and pharmacological efficacy, artificial breeding and cultivation techniques, and utilization value of P. fallax Hemsl. (Polygalaceae) to facilitate future studies on the conservation and use of P. fallax Hemsl plants. We conclude that (i) P. fallax Hemsl. (Polygalaceae) is a medicinal and edible plant, and also has eco-economic and ornamental value; (ii) roots are the primary medicinal parts, which contain pharmacologically active compounds such as saponins, flavones, oligosaccharide polyesters, polysaccharides, sterols, organic acids, etc.; and (iii) P. fallax Hemsl. (Polygalaceae) shows various pharmacological efficacies including anti-inflammatory effects, antivirus effects, antioxidative effects, an immunity-boosting function, hepatic-protective effects, hypolipidemic effect, blood-activating, stasis-eliminating effects, and antitumor, etc. More research on the applications of P. fallax Hemsl. (Polygalaceae) are needed, especially efforts to identify its effective constituents, pharmacological efficacy, quality control, and clinical applications. The use of P. fallax Hemsl. (Polygalaceae) resources should be enhanced, especially the use of the aboveground parts, and the pharmacological efficacy of other chemical constituents, such as flavones and polysaccharides, should be further explored.

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Section: Compounds Extractive Fractions Referencementioning

confidence: 99%

“…Saponins, polysaccharides [40,45] Antitumor The isolated flavones show tumor cytotoxic activity. Flavones [37] Anti-inflammatory effects The extracts inhibit the increase of vascular permeability caused by inflammatory mediators and inflammatory reactions and inhibit the immune inflammatory process.…”

Section: Hypolipidemic Effectmentioning

confidence: 99%

Research Progress on the Medicinal and Edible Polygala fallax Hemsl. (Polygalaceae) Plant

et al. 2023

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Undergraduates’ comparative assessment, utilizing a structured rubric, of hands-on versus video-supported presentation in class II cavity preparation

Mittal,

Jadhav,

Abdul Kader M

et al. 2024

THC

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BACKGROUND: Dental education is considered as a complex, challenging and often stressful educational procedure. Acquisition of psychomotor skills by undergraduate students is an important step in many health professions to become a successful professional. During under graduation, class II cavity preparation exercise is of utmost important in dentistry. OBJECTIVE: To compare class II cavities prepared by students after hands-on live demonstration and pre-recorded video demonstration using well-organised evaluation rubrics. METHOD: Preclinical dental students (n= 50) were divided into two groups. The students in group I (n= 25) attended a hands-on live demonstration performed by one faculty while students in group II (n= 25) watched a 15-minute pre-recorded procedural video on the projector. Both groups were appealed to prepare class II cavity for amalgam involving disto-occlusal surface of mandibular second molar articulated on jaw model (TRU LON study model, Jayna industries, Ghaziabad U.P., India). Following completion of the preparations, all teeth were collected, and labelled grades of prepared cavities were given according to prespecified rubrics. The data of scores were presented as means and standard deviation. Statistical analysis of data was executed using SPSS software. A paired t-test was used to compare scores between groups. RESULTS: The study shows that the video-supported demonstration of a cavity preparation was better than the live hands-on demonstration. A higher mean response for the procedural video group was found compared to the live demonstration group (p= 0.000133). CONCLUSION: Pre-recorded video-supported demonstration along with guidance by a tutor may be a viable alternative to hands-on live demonstration in cavity preparation procedures during undergraduate dental training. Moreover, rubric methods can be implemented in the teaching of various preclinical exercises for conservative dentistry and endodontics.

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Extract identification and evaluation of the cytotoxic activity of Polygala fallax Hemsl in Heilongjiang ethnic medicine against tumors

Cited by 2 publications

References 32 publications

Research Progress on the Medicinal and Edible Polygala fallax Hemsl. (Polygalaceae) Plant

Research Progress on the Medicinal and Edible Polygala fallax Hemsl. (Polygalaceae) Plant

Undergraduates’ comparative assessment, utilizing a structured rubric, of hands-on versus video-supported presentation in class II cavity preparation

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