Extract-mediated biosynthesis and characterization of gold nanoparticles: Exploring their protective effect against cyclophosphamide-induced oxidative stress in rat testis

Mobaraki, Fahimeh; Momeni, Mohsen; Barghbani, Maryam; Far, Bahareh Farasati; Hosseinian, Sara; Hosseini, Seyed Mousalreza

doi:10.1016/j.jddst.2022.103306

Cited by 9 publications

(7 citation statements)

References 83 publications

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“…These studies highlight the advantages of using plant extracts in NP synthesis, such as their low hazardous effects on the environment and low toxicity for the human body. 51 Green synthesis of NPs using plant extracts has gained attention due to its clean, eco-friendly, cost-effective, and safe nature. Plant extracts contain reducible phytoconstituents like alkaloids, flavonoids, and tannins, which can effectively reduce metal ions and facilitate the synthesis of NPs.…”

Section: Synthesis Techniquesmentioning

confidence: 99%

Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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Section: Synthesis Techniquesmentioning

confidence: 99%

Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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“…37,38 The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption rate, which is caused by an imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms. 39 The brain comprises readily oxidized lipids and has fewer enzymatic defenses against oxidative stress. Neurological conditions like AD may arise because of this harm to proteins, DNA, and the 47 (B) depicting a schematic illustration of the potential mechanism for gradually targeting cell membrane biomimetic nanoparticles (NPs) that have been modified with targeting peptides.…”

Section: Curcumin Benefiting Ad: Mechanism Of Actionmentioning

confidence: 99%

“…The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption rate, which is caused by an imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms . The brain comprises readily oxidized lipids and has fewer enzymatic defenses against oxidative stress.…”

Section: Curcumin Benefiting Ad: Mechanism Of Actionmentioning

confidence: 99%

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Far,

Safaei,

Pourmolaei

et al. 2024

ACS Appl. Bio Mater.

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Alzheimer's disease (AD) is a neurological condition currently with 47 million people suffering from it globally. AD might have many reasons such as genetic issues, environmental factors, and Aβ accumulation, which is the biomarker of the disease. Since the primary reason is unknown, there is no targeted treatment at the moment, but ongoing research aims to slow its progression by managing amyloid-beta peptide production rather than symptomatic improvement. Since phytochemicals have been demonstrated to possess antioxidant, anti-inflammatory, and neuroprotective properties, they may target multiple pathological factors and can reduce the risk of the disease. Curcumin, as a phytochemical found in turmeric known for its antioxidant, free radical scavenging properties, and as an antiamyloid in treating AD, has come under investigation. Although its low bioavailability limits its efficacy, a prominent drug delivery system (DDS) is desired to overcome it. Hence, the potency of lipid-based nanoparticles encapsulating curcumin (LNPs-CUR) is considered in this study as a promising DDS. In vivo studies in animal models indicate LNPs-CUR effectively slow amyloid plaque formation, leading to cognitive enhancement and reduced toxicity compared to free CUR. However, a deeper understanding of CUR's pharmacokinetics and safety profile is crucial before LNPs-CUR can be considered as a medicine. Future investigations may explore the combination of NPs with other therapeutic agents to increase their efficacy in AD cases. This review provides the current position of CUR in the AD therapy paradigm, the DDS suggestions for CUR, and the previous research from the point of analytical view focused on the advantages and challenges.

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“…[ 10 ] Animal studies have shown that CP leads to decreased testicular weight and transient oligospermia. [ 11 ] It also reduces DNA synthesis in spermatogonia and protein synthesis in spermatids. [ 12 ] Other testicular side effects of CP are including extensive bleeding in the interstitial seminiferous tubules (ST), complete separation between different stages of spermatogenic cells, the presence of vacuoles in spermatogenic lineage cells, and other changes in the tissue structure of the testis.…”

Section: Introductionmentioning

confidence: 99%

Piperine mitigates oxidative stress, inflammation, and apoptosis in the testicular damage induced by cyclophosphamide in mice

Fani,

Hosseinimehr,

Zargari

et al. 2024

J Biochem & Molecular Tox

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Although cyclophosphamide (CP) has been approved as an anticancer drug, its toxic effect on most organs, especially the testis, has been established. Piperine (PIP) is an alkaloid that has antioxidant, antiapoptotic, and anti‐inflammatory activities. This study was investigated the protective effects of PIP on CP‐induced testicular toxicity in the mice. In this experimental study, 48 adult male BALB/c mice (30−35 g) were divided into six groups (n = 8), receiving normal saline (C), 5 mg/kg of PIP (PIP5), 10 mg/kg of PIP (PIP10), 200 mg/kg of CP, 200 mg/kg of CP + PIP5, and 200 mg/kg of CP + PIP10. On the eighth day of the study, blood and testis samples were prepared for serum testosterone hormone quantification, sperm analysis, histological, and immunohistochemical assays. The results of this study showed that CP induced testicular toxicity with the decrease of sperm count, motility, and viability. Also, CP treatment caused histological structure alterations in the testis, including exfoliation, degeneration, vacuolation of spermatogenic cells, and reducing the thickness of the epithelium and the diameter of the seminiferous tubule. In addition, CP decreased glutathione (GSH) levels, increased malondialdehyde (MDA) levels, Caspase‐3, and NF‐κB. At the same time, PIP treatment reduced testicular histopathological abnormalities, oxidative stress, and apoptosis that were induced by CP. These results showed that PIP improved CP‐induced testicular toxicity in mice, which can be related to its antioxidant, antiapoptotic, and anti‐inflammatory activities.

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Extract-mediated biosynthesis and characterization of gold nanoparticles: Exploring their protective effect against cyclophosphamide-induced oxidative stress in rat testis

Cited by 9 publications

References 83 publications

Biomedical applications of cerium vanadate nanoparticles: a review

Biomedical applications of cerium vanadate nanoparticles: a review

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Piperine mitigates oxidative stress, inflammation, and apoptosis in the testicular damage induced by cyclophosphamide in mice

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