Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito

Bezerra-Silva, Patrícia Cristina; Santos, Jefferson Cleriston Barros dos; Santos, Geanne K.N.; Dutra, Kamilla A.; Santana, Andréa Lopes Bandeira Delmiro; Maranhão, Claudia A.; Nascimento, Márcia Silva do; Navarro, Daniela Maria do Amaral Ferraz; Bieber, Lothar W.

doi:10.1016/j.exppara.2015.03.018

Cited by 18 publications

(16 citation statements)

References 42 publications

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“…In popular medicine, there are reports of the use of its bark and seeds in the form of an infusion to treat various diseases, such as arthritis, diabetes, bronchitis, and skin wounds [ 16 ]. Phytochemical studies revealed that the bark and roots contain a large number of alkaloids and terpenoids, such as lupeol [ 17 , 18 ], volatile constituents and flavonoids [ 19 , 20 ], and anthocyanins [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways

et al. 2018

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Skin wound healing is a dynamic and complex process involving several mediators at the cellular and molecular levels. Lupeol, a phytoconstituent belonging to the triterpenes class, is found in several fruit plants and medicinal plants that have been the object of study in the treatment of various diseases, including skin wounds. Various medicinal properties of lupeol have been reported in the literature, including anti-inflammatory, antioxidant, anti-diabetic, and anti-mutagenic effects. We investigated the effects of lupeol (0.1, 1, 10, and 20 μg/mL) on in vitro wound healing assays and signaling mechanisms in human neonatal foreskin keratinocytes and fibroblasts. Results showed that, at high concentrations, Lupeol reduced cell proliferation of both keratinocytes and fibroblasts, but increased in vitro wound healing in keratinocytes and promoted the contraction of dermal fibroblasts in the collagen gel matrix. This triterpene positively regulated matrix metalloproteinase (MMP)-2 and inhibited the NF-κB expression in keratinocytes, suggesting an anti-inflammatory effect. Lupeol also modulated the expression of keratin 16 according to the concentration tested. Additionally, in keratinocytes, lupeol treatment resulted in the activation of Akt, p38, and Tie-2, which are signaling proteins involved in cell proliferation and migration, angiogenesis, and tissue repair. These findings suggest that lupeol has therapeutic potential for accelerating wound healing.

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Section: Introductionmentioning

confidence: 99%

Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways

et al. 2018

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“…The interest as well as the utilization of natural products as potential larvicides have been increasing, as these products are less harmful to non-target organisms (Ali, Ravikumar, & Beula, 2013), besides regulating the growth of insects (Bezerra-Silva et al, 2015). Furthermore, they stand out as alternatives to conventional chemical pesticides, for instance organochlorides and organophosphates, which, upon indiscriminate use, lead to the selection of more resistant vectors, such as Aedes aegypti L. (Belinato & Valle, 2015).…”

Section: Introductionmentioning

confidence: 99%

<b>Larvicidal, cytotoxic and genotoxic effects of aqueous leaf extract of <i>Jatropha mollissima</i> (Pohl) Baill

Araujo

Costa

Oliveira

et al. 2018

Acta Sci. Biol. Sci.

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ABSTRACT. The present study aimed to evaluate the larvicidal effect of aqueous leaf extract from Jatropha mollissima on the larvae of Aedes aegypti and analyze its cytotoxic and genotoxic activity in the Allium cepa test. Larvae of the mosquito were exposed to the negative and positive controls (distilled water and diflubenzuron, 0.003 mg mL -1 , respectively) and to leaf extract concentrations of 0.001, 0.005, 0.01, 0.02, 0.04, 0.06, 0.08 and 0.1 mg mL -1 . The mortality rate was evaluated every 24 hours over five days. For the cytotoxic and genotoxic analyses, roots of A. cepa were exposed to the negative (distilled water) and positive control (trifluralin, 0.84 ppm) and to different leaf extract concentrations (0.01, 0.1, 1 and 10 mg mL Efeitos larvicida, citotóxico e genotóxico do extrato aquoso das folhas de Jatropha mollissima (Pohl) Baill RESUMO. O presente estudo teve como objetivo avaliar o efeito larvicida do extrato aquoso das folhas de Jatropha mollissima sobre as larvas de Aedes aegypti e analisar sua atividade citotóxica e genotóxica no teste Allium cepa. As larvas do mosquito foram expostas aos controles negativo e positivo (água destilada e diflubenzuron, 0,003 mg mL -1 , respectivamente) e ao extrato foliar nas concentrações de 0,001; 0,005; 0,01; 0,02; 0,04; 0,06; 0,08 e 0,1 mg mL -1 . A taxa de mortalidade foi avaliada a cada 24horas durante cinco dias. Para as análises citotóxica e genotóxica, as raízes de A. cepa foram expostas ao controle negativo (água destilada) e positivo (trifluralina, 0,84 ppm) e nas concentrações (0,01; 0,1; 1 e 10 mg mL -1 ) do extrato foliar por 24 horas. Análises estatísticas foram realizadas pelo teste de Kruskal-Wallis (p < 0,05). O extrato foliar apresentou atividade larvicida promissora nas concentrações de 0,08 e 0,1 mg mL -1 , e nenhuma das concentrações avaliadas em A. cepa exibiu efeito citotóxico ou genotóxico. Uma vez demonstrada a ação larvicida de J. mollissima e a ausência de toxicidade celular, mais estudos são recomendados para determinar o mecanismo de ação do extrato como um possível larvicida natural.

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“…Some studies have reported the insecticidal potential of C. brasiliense against the grain-infesting insects S. zeamais and Callosobruchus maculatus (Coitinho et al, 2006;Pereira et al, 2008) and of angico against S. zeamais (Lima- Mendonça et al, 2013). Furthemore, we highlight the studies on the insecticidal potential of A. colubrina, P. macroloba, and V. polysphaera on insect vectors of human diseases (Macêdo et al, 1997;Santiago et al, 2005;Bezerra-Silva et al, 2015).…”

Section: Discussionmentioning

confidence: 96%

Use of plant oils from the southwestern Amazon for the control of maize weevil

Santos

Fernandes

Lopes

et al. 2015

Journal of Stored Products Research

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Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito

Cited by 18 publications

References 42 publications

Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways

Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways

<b>Larvicidal, cytotoxic and genotoxic effects of aqueous leaf extract of <i>Jatropha mollissima</i> (Pohl) Baill

Use of plant oils from the southwestern Amazon for the control of maize weevil

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