Extract of Carica papaya L. leaves: Standardising its use in dengue fever

Ansari, Reshma Mohamed

doi:10.4103/0253-7613.182892

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…Carica papaya displayed antimalarial effect this has ability to reduce the erythrocytes stages (merozoites, schizonts and gametocytes) of P. berghei and hence justify its traditional usage of malaria remedy. This is in tandem with previous research that C. papaya L. extracted from leaf was reported having antidengue, anti-inflammatory and antimalarial (Charan et al, 2016;Pandey et al, 2016;Ansari, 2016).…”

Section: Discussionsupporting

confidence: 90%

Evaluation of Antimalarial Activity of Methanolic Extract of Carica Papaya (Carecaccaea) Yellow Leaf in Mice

2023

Russian Journal of Biological Research

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Malaria still remains a public health problem in developing countries. Malaria is one of the most prevalent diseases as people still rely on traditional medicine as source of treatment for this disease. Malaria causes mortality and morbidity with social economic impact in developing countries where the burden is high. Reports showed that the high global health challenges is partly due to multidrug resistance P. falciparum develop on existing and available antimalarial drugs and that has spur the search of alternate treatment with low or less side effect. The purpose of this study is to evaluate the antimalarial potential of methanolic extract of Carica papaya yellow leaf on animal model. In vivo screening for antimalarial drug discovery is of the recommended stream line process for new compound in path from drug discovery to developing. The Rane's curative method of established infection was employed in vivo for assessing antimalarial activity. Swiss albino mice of both sexes weighing between 23-27 g and aged 6 weeks were infected with 1x10 -7 P. berghei (NK-65) RBC/ml intraperitoneally and were treated with various dose (100, 200 and 400mg/lg bt.wt) of C. papaya yellow leaf methanolic extract. Acute oral toxicity test was employed using OECD method. The mice treated with 400 mg/kg b.wt of C. papaya yellow leaf extract showed significant (P < 0.05) antimalarial activity. In acute oral toxicity result showed that the maximum tolerated dose was found to be 5000 mg/kg body weight. C. papaya leaf extract showed antimalarial activity and study has validated its use by locals in the treatment of malaria in most developing countries. Recommendations are made for the isolation and identification of bioactive substance for possible drug development.

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Section: Discussionsupporting

confidence: 90%

Evaluation of Antimalarial Activity of Methanolic Extract of Carica Papaya (Carecaccaea) Yellow Leaf in Mice

2023

Russian Journal of Biological Research

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“…Certain platelet type genes Arachidonate 12lipoxygenase (ALOX 12) too recognized as lipoxygenase (ALOX 12) help in megakaryocyte production and differentiation which lead to 12hydroxyeicosatetraenoic acid production and in that production of platelet [9] and Platelet-Activating Factor Receptor (PTAFR) gene expression in megakaryocytes indicate that it will probably be a forerunner for platelet production in addition it also involved in aggregation of platelet [67].…”

Section: Overview Of Dengue Fevermentioning

confidence: 99%

Advancement and Future Directions towards Herbal Treatment for Various Diseases

Ghani¹,

Batool²,

Rafeeq³

et al. 2019

SJMPS

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The purpose of review article is to find herbal drug for treatment of some diseases. Several side effects came from chemical drugs. Use of non-chemical, non-invasive natural remedies have no major adverse effect because contain naturally active biological components, therefore they have paying much attention within recent years. Possible usage of leaf extract of Papaya for treatment of dengue fever promising cure for dengue patients. Pomegranate contains high level of antioxidants which make it one of the best fruits for boosting blood count. Phenolic compound extraction from extra virgin olive oil has immune modulatory and anti-inflammatory effects in Systemic lupus erythematosus (SLE) patients. Wound healing properties are exerted from aloe Vera gel. Fenugreek seed best natural remedy for Poly ovarian cyst syndrome (POCS). Garlic and ginger are organosulfur compounds consisting upon its bio actives having an important role in cardiovascular diseases and cancer respectively.Nigella sativa recently demonstrates the role in diabetes mellitus. Allium cepa. L (Onion) contain phytochemicals that have antidiabetic, anticarcinogenic, anti-inflammatory, antibiotic, antioxidant, antimicrobial and antiplatelet effects on the human health.

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“…[ 13 , 14 , 15 ] or through an immune response [ 16 , 17 , 18 ]. Several studies have concluded that papaya leaves can significantly increase platelet count [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Carica papaya (CP), a member of the family Caricaceae, grows in the West Indies, the Philippines, Sri Lanka, India, Bangladesh, Malaysia and other countries in tropical America.…”

Section: Introductionmentioning

confidence: 99%

Papaya Leaf Extracts as Potential Dengue Treatment: An In-Silico Study

Madushanka

Verma

Freindorf

et al. 2022

IJMS

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Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) cause serious public health problems, with nearly 390 million people affected and 20,000 deaths per year in tropical and subtropical countries. Despite numerous attempts, no antiviral drug or vaccine is currently available to combat the manifestation. The challenge of discovering an efficient vaccine is enhanced by the surplus presence of efficient vectors and drug resistance from the virus. For centuries, papaya (Carica papaya) extracts have been traditionally used to treat DF, DHF, and DSS. In the present study, we systematically investigated seven compounds isolated from papaya leaf extract with regard to their potential as inhibitors for non-structural (NS) proteins, NS3 and NS5, which play a crucial role in viral RNA replication. The computational tools applied stretched across classical molecular docking, molecular dynamics (MD) simulations and SwissADME used to calculate binding affinities; binding free energies; Absorption, Distribution, Metabolism, and Excretion (ADME); and drug-likeness properties, thus, identifying Kaempferol, Chlorogenic acid, and Quercetin as potential candidates, with Kaempferol and Quercetin scoring best. Therefore, for the Kaempferol and Quercetincomplexes, hybrid quantum mechanical/molecular mechanical (QM/MM) geometry and frequency calculations were performed, followed by the local mode analysis developed in our group to quantify Kaempferol-NS and Quercetin-NS hydrogen bonding. Given the non-toxic nature and the wide availability of the Kaempferol and Quercetin papaya extract in almost all of the susceptible regions, and our results showing high NS3 and NS5 binding affinities and energies, strong hydrogen bonding with both NS3 and NS5, and excellent ADME properties, we suggest Kaempferol and Quercetin as a strong NS3 and NS5 inhibitor to be further investigated in vitro.

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Extract of Carica papaya L. leaves: Standardising its use in dengue fever

Cited by 7 publications

References 4 publications

Evaluation of Antimalarial Activity of Methanolic Extract of Carica Papaya (Carecaccaea) Yellow Leaf in Mice

Evaluation of Antimalarial Activity of Methanolic Extract of Carica Papaya (Carecaccaea) Yellow Leaf in Mice

Advancement and Future Directions towards Herbal Treatment for Various Diseases

Papaya Leaf Extracts as Potential Dengue Treatment: An In-Silico Study

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