Extract of Ocimum canum lowers blood glucose and facilitates insulin release by isolated pancreatic β-islet cells

Nyarko, Alexander Kwadwo; Asare‐Anane, Henry; Ofosuhene, Mark; Addy, Marian E.

doi:10.1078/0944-7113-00124

Cited by 45 publications

(20 citation statements)

References 16 publications

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“…ADD-199 like glibenclamide and metformin increased plasma insulin levels in the diabetic mice in a dose-dependent fashion. This plant preparation may therefore act like Ocimum canum, another antidiabetic plant extract and the sulphonylureas to promote insulin release by ␤-cells of the pancreas (BNF, 1995;Nyarko et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

The antidiabetic activity of the herbal preparation ADD-199 in mice: a comparative study with two oral hypoglycaemic drugs

Okine

Nyarko

Osei-Kwabena

et al. 2005

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

The antidiabetic activity of the herbal preparation ADD-199 in mice: a comparative study with two oral hypoglycaemic drugs

Okine

Nyarko

Osei-Kwabena

et al. 2005

Journal of Ethnopharmacology

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“…(Lamiaceae), commonly known, as hoary basil, is widely distributed in tropical and subtropical parts of the world, but most prevalent throughout Indian subcontinent (Paton et al 1999). Traditionally, this species is widely used for medicinal propose as well as source of aromatic compounds and essential oils containing biologically active constituents against diabetes (Nyarko et al 2002), various bacteria, fungi (Hassane et al 2012;Saha et al 2013) and parasites (Jayaseelan and Rahuman 2012). However, a major difficulty in the use of Lamiaceous species like Ocimum spp.…”

Section: Introductionmentioning

confidence: 99%

Micropropagation and analysis of genetic stability in regenerated plantlets of Ocimum canum Sims.

Saha

Roy

Sengupta

et al. 2014

Ind J Plant Physiol.

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An efficient and improved plant regeneration protocol has been developed from nodal explants of Ocimum canum Sims., a medicinally important herbaceous plant species belonging to the family Lamiaceae. Murashige and Skoog (MS) basal medium supplemented with 0.5 mg l -1 N 6 -benzyladenine (BA) showed maximum percentage of shoot multiplication (91.1 %) with 5.32 shoots per explant. Rooting of shoots occurred on 1/2 MS medium supplemented with 1.0 mg l -1 indole-3-butyric acid (IBA). Well-developed plantlets, transferred to plastic pots containing sand, soil and compost (2:2:1) showed 80.9 % survival rate under field condition. The genetic fidelity of in vitro raised field-grown plants to the donor plant was ascertained from histological, cytological and two PCR based molecular markers, i.e., random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR). Histological study showed direct organogenesis on epidermal and sub epidermal layer, where as cytological studies showed no visible anomalies within its chromosome compliments. Both RAPD and ISSR analysis revealed high degree of monomorphism, similar to those of the mother plants. This method of in vitro clonal propagation of O. canum Sims. may, therefore, could be an avenue of its sustainable commercial exploitation and conservation.

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“…It belongs to the family Lamiaceae, subfamily Ocimoideae, and comprises more than 30 species distributed in tropical and subtropical regions of Asia, Africa, and Central and South America (Paton 1992). Traditionally, the genus Ocimum is widely used for the treatment of various ailments including rheumatism, paralysis, epilepsy, high fever, diarrhea, sunstroke, influenza, gonorrhea, mental illness, abdominal pains, colds, coughs, measles, and has also antipyretic, antihelmentic, stomatic, anti-emetic, and antimalarial effects (Caceres et al 1990;Obeng-Ofori et al 1998;Nyarko et al 2002;Ezekwesili et al 2004). It is also a source of aroma compounds and essential oils containing biologically active constituents that possess insecticidal (Deshpande et al 1997), nematicidal (Chaterjee et al 1982), and fungistatic properties (Reuveni et al 1984).…”

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confidence: 99%

Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria

Saha¹,

Dhar²,

Sengupta³

et al. 2013

Czech J. Food Sci.

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Saha S., Dhar T.N., Sengupta C., Ghosh P.D. (2013): Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria. Czech J. Food Sci., 31: 194-202.The essential oils and methanol extracts of Ocimum basilicum L., Ocimum kilimandscharicum Guerke, Ocimum gratissimum L, Ocimum canum Sims, and Ocimum tenuiflorum L. (green type) were examined for their potential antibacterial activities. The chemical composition of essential oils of Ocimum species was analysed by GC-MS. The inhibitory effects of essential oils and methanol extracts were studied on two Gram-positive (Bacillus subtilis, Micrococcus luteus) and five Gram-negative (pseudomonas aeruginosa, Shigella dysenteriae, escherichia coli, Vibrio cholera, and Shigella flexneri) bacteria using disc-diffusion method. Minimum inhibitory concentration (MIC) was assessed by micro broth dilution method. The antibacterial test results showed that the essential oils of Ocimum basilicum L., Ocimum kilimandscharicum Guerke, and Ocimum gratissimum L. strongly inhibited the growth of all of the microorganisms studied, especially of the Gram-negative strains, whereas other two essential oils showed moderate activities. The result may suggest that the essential oils of Ocimum possess compounds with antibacterial activities, and therefore could be used as natural preservative ingredients in food and/or pharmaceutical industries.

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Extract of Ocimum canum lowers blood glucose and facilitates insulin release by isolated pancreatic β-islet cells

Cited by 45 publications

References 16 publications

The antidiabetic activity of the herbal preparation ADD-199 in mice: a comparative study with two oral hypoglycaemic drugs

The antidiabetic activity of the herbal preparation ADD-199 in mice: a comparative study with two oral hypoglycaemic drugs

Micropropagation and analysis of genetic stability in regenerated plantlets of Ocimum canum Sims.

Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria

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