Extract of Pigs’ Heart Cryopreserved Fragments as a Regulator of State of Rats Heart Muscle in Myocardial Necrosis Model

Chyzh, Mykola; Babaieva, G. G.; Rohoza, L. A.; Halchenko, S. Ye.

doi:10.29254/2077-4214-2020-4-158-78-83

VPBM

2020

DOI: 10.29254/2077-4214-2020-4-158-78-83

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Extract of Pigs’ Heart Cryopreserved Fragments as a Regulator of State of Rats Heart Muscle in Myocardial Necrosis Model

Mykola Chyzh

G. G. Babaieva

L. A. Rohoza

et al.

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2022

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Cited by 2 publications

References 7 publications

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Cardioprotective Effect of Enkephalins Under Immobilization Stress

Shcheniavskyi¹

2022

Biotechnol. acta

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Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for two months, by the use of immobilization stress. The experimental results indicated that the applied model allowed to induce the development of myocardial infarction within one three days, which was confirmed by electrocardiography, enzyme-linked immunosorbent assay and histological examination. Results: Pre-treatment of rats with dalargin had no prevented myocardial infarction, however, it increased the resistance to immobilization stress and reduced infarction-induced myocardial lesions. Simultaneous administration of naloxone, an opiate receptor antagonist, together with dalargin eliminated its cardioprotective effect in experimental animals. Conclusion: The use of synthetic leu-enkephalin dalargin significantly reduced the risk of myocardial infarction caused by excessive neuromuscular stress. The dalargin effect on the myocardium was mediated by opiate receptors.

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Cardioprotective Effect of Enkephalins Under Immobilization Stress

Shcheniavskyi¹

2022

Biotechnol. acta

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Cardioprotective Effect of Low Molecular Weight (Below 5 kDa) Fraction of Cattle Cord Blood Cryohemolysate

Shcheniavsky¹,

Kovalenko²,

Gulevsky³

2022

Probl Cryobiol Cryomed

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In this report, we have studied a cardioprotective effect of low molecular weight (below 5 kDa) fraction derived from cattle cord blood in a rat model of infarction-like cardiovasopathy. The myocardial infarction development was initiated in the animals, maintained for two months on a diet with excessive intake of fat, calcium and sodium salts, by making hypoxia-hypercapnia in them. The use of this model allowed inducing the infarction-like cardiovasopathy, comparable by many respects with the clinical picture of myocardial infarction, which was confirmed by electrocardiography, enzyme-linked immunosorbent assay and histological analysis. Preliminary administration of low molecular weight (below 5 kDa) fraction of cattle cord blood, as well as Actovegin did not prevent the heart attack, but increased the endurance of rats to hypoxia-hypercapnia and reduced the damage rate to myocardium. A preventive administration of low molecular weight fraction of cord blood was proven to mitigate the risk of hypoxia-induced damages to myocardium.

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Extract of Pigs’ Heart Cryopreserved Fragments as a Regulator of State of Rats Heart Muscle in Myocardial Necrosis Model

Cited by 2 publications

References 7 publications

Cardioprotective Effect of Enkephalins Under Immobilization Stress

Cardioprotective Effect of Enkephalins Under Immobilization Stress

Cardioprotective Effect of Low Molecular Weight (Below 5 kDa) Fraction of Cattle Cord Blood Cryohemolysate

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