Extract of Tagetes erecta L., a medicinal plant rich in lutein, promotes gastric healing and reduces ulcer recurrence in rodents

Meurer, Mariane; Gonçalves, Beatriz; Cury, Benhur Judah; Jerônimo, Daniele T.; Venzon, Larissa; França, Tauani Caroline Santos; Mariott, Marihá; Nunes, Ruan Kaio da Silva; Santos, Ana Caroline dos; Roman-Junior, Walter A.; Oliveira, Ruberlei Godinho de; Arunachalam, Karuppusamy; Santin, José Roberto; Benvenutti, Larissa; Souza, Priscila de; Mejía, Jennyfer Andrea Aldana; Silva, Luísa Mota da

doi:10.1016/j.jep.2022.115258

Cited by 17 publications

(6 citation statements)

References 44 publications

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“… DSS Vehicle (10 mL/kg water + 1% Tween 80) contained DSS as a negative control and 5-aminosalicylic acid (ASA) (100 mg/kg) for the positive control Ranitidine 9 The extract reduced the ulcerated area by 66%, expedited the healing of stomach ulcers, increased GST activity and mucin quantity, decreased LOOH levels, SOD, CAT, and MPO activities, and decreased the lesion area in the recurrence model by 94%, decreased the thickness of the stomach wall and TNF levels, and raised the amount of IL-10. Strong activity [ 41 ] Taraxacum officinale (Asteraceae); 2018 Root; Water In vivo on C57BL/6 mice ( M. musculus ) aged 6–8 weeks old (n= 40) Bethanechol Vehicle (water 2% w/v contained DSS) as a negative control and for the positive control is not applicable. 10 The extract effectively reduces progressive acute injury as evidenced by decreased body weight loss, reduced disease index severity scores, and shorter colon length during DSS treatment.…”

Section: Resultsmentioning

confidence: 99%

Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies

Prayoga,

Aulifa,

Budiman

et al. 2024

DDDT

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Ulcer disorders including the oral mucosa, large intestine, and stomach mucosa, cause significant global health burdens. Conventional treatments such as non-steroid anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), histamine H 2 receptor antagonists (H 2 RAs), and cytoprotective agents have drawbacks like mucosal injury, diminish gastric acid secretion, and interact with concurrent medications. Therefore, alternative therapeutic approaches are needed to tackle this health concern. Plants are rich in active metabolites in the bark, roots, leaves, fruits, and seeds, and have been utilized for medicinal purposes since ancient times. The use of herbal therapy is crucial, and regulations are necessary to ensure the quality of products, particularly in randomized studies, to assess their efficacy and safety in treating ulcer disorders. This study aims to explore the anti-ulcer activity of medicinal plants in treating peptic ulcer disease, ulcerative colitis, and aphthous ulcers. Articles were searched in Scopus and PubMed, and filtered for publication from 2013 to 2023, resulting in a total of 460 from Scopus and 239 from PubMed. The articles were further screened by title and abstract and resulted in 55 articles. Natural products, rich in active metabolites, were described to manage ulcer disease by protecting the mucosa, reducing ulcer effects, inhibiting pro-inflammatory factors, and reducing bacterial load, thus improving patients’ quality of life. Natural extracts have proven effective in managing other health problems, including ulcers by reducing pain and decreasing lesions. This review provides an overview of preclinical and clinical studies on medicinal plants, focusing on their effectiveness in treating conditions like peptic ulcers, ulcerative colitis, and aphthous ulcers.

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Section: Resultsmentioning

confidence: 99%

Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies

Prayoga,

Aulifa,

Budiman

et al. 2024

DDDT

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show abstract

“…The resulting supernatant was cultured in 80 mM phosphate buffer (pH 5.4), containing 1.6 mM tetramethylbenzidine and 0.3 mM hydrogen peroxide. The quantity of MPO activity in the pancreas was measured by determining the absorbance at 460 nm after the addition of a 0.2 M sulfuric acid solution, with duration of 2 min [ 51 ]. The absorbance at 585 nm was measured in order to determine the 5-LO activity, according to Wu [ 52 ].…”

Section: Methodsmentioning

confidence: 99%

Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential

Abdella,

Toumi,

Boudriga

et al. 2024

Heliyon

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“…Some authors have studied the possible biological activities of extracts obtained from the petals of Mexican marigolds [ 5 ]. They reported effects against Alzheimer’s disease-related amyloidosis in worms [ 6 ] and described its gastric healing activity in a murine model [ 7 ]. These activities could be associated with various chemical components including carotenoids [ 7 ] and polyphenols [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…They reported effects against Alzheimer’s disease-related amyloidosis in worms [ 6 ] and described its gastric healing activity in a murine model [ 7 ]. These activities could be associated with various chemical components including carotenoids [ 7 ] and polyphenols [ 6 ]. Some authors have identified lutein (a carotenoid) and laricitrin (a flavonoid) as the main chemical structures abundant in T. erecta and responsible for its biological activities [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Properties of Tagetes erecta Edible Flowers: Polyphenol and Antioxidant Characterization and Therapeutic Activity against Ovarian Tumoral Cells and Caenorhabditis elegans Tauopathy

Rivas-García,

Crespo-Antolín,

Forbes-Hernández

et al. 2023

IJMS

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Tagetes erecta is an edible flower deeply rooted in traditional Mexican culture. It holds a central role in the most popular and iconic Mexican celebration, “the Day of the Dead”. Furthermore, it is currently receiving interest as a potential therapeutic agent, motivated mainly by its polyphenol content. The present study aims to evaluate the biological activity of an extract synthesized from the petals of the edible flower T. erecta. This extract showed significant antioxidant scores measured by the most common in vitro methodologies (FRAP, ABTS, and DPPH), with values of 1475.3 μM trolox/g extr, 1950.3 μM trolox/g extr, and 977.7 μM trolox/g extr, respectively. In addition, up to 36 individual polyphenols were identified by chromatography. Regarding the biomedical aspects of the petal extract, it exhibited antitumoral activity against ovarian carcinoma cells evaluated by the MTS assay, revealing a lower value of IC50 compared to other flower extracts. For example, the extract from T. erecta reported an IC50 value half as low as an extract from Rosa × hybrida and six times lower than another extract from Tulbaghia violacea. This antitumoral effect of T. erecta arises from the induction of the apoptotic process; thus, incubating ovarian carcinoma cells with the petal extract increased the rate of apoptotic cells measured by flow cytometry. Moreover, the extract also demonstrated efficacy as a therapeutic agent against tauopathy, a feature of Alzheimer’s disease (AD) in the Caenorhabditis elegans experimental model. Treating worms with the experimental extract prevented disfunction in several motility parameters such as wavelength and swimming speed. Furthermore, the T. erecta petal extract prevented the release of Reactive Oxygen Species (ROS), which are associated with the progression of AD. Thus, treatment with the extract resulted in an approximate 20% reduction in ROS production. These findings suggest that these petals could serve as a suitable source of polyphenols for biomedical applications.

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Extract of Tagetes erecta L., a medicinal plant rich in lutein, promotes gastric healing and reduces ulcer recurrence in rodents

Cited by 17 publications

References 44 publications

Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies

Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies

Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential

Bioactive Properties of Tagetes erecta Edible Flowers: Polyphenol and Antioxidant Characterization and Therapeutic Activity against Ovarian Tumoral Cells and Caenorhabditis elegans Tauopathy

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