Extract of white button mushroom affects skin healing and angiogenesis

Lam, Wai Ping; Wang, C.M.; Tsui, TY; Wai, Maria S. M.; Tang, Hong; Wong, Yee-Lok; Lam, L.H.; Hui, L.K.; Yew, David T.

doi:10.1002/jemt.22071

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Especially, polysaccharides are considered to be one of the major active substances in C. militaris and possess various physiological activities; it has been used for multiple medicinal purposes such as hypoglycemic, hypolipidemic, anti-inflammatory, antitumor, anti-metastatic, immunomodulatory, and antioxidant effect [14,15,16,17,18]. In recent years, many cosmetics and skin care products have been supplemented with natural products including mushroom has claimed much attention [19,20]. However, there have been no reports on the preventive effects of C .…”

Section: Introductionmentioning

confidence: 99%

Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Park

Lee

et al. 2014

Nutrients

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Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs). Our results showed that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CME was increased in a dose-dependent manner. We found that hydrogen peroxide treatment in HDFs increased ROS generation and cell death as compared with the control. However, CME improved the survival of HDFs against hydrogen peroxide-induced oxidative stress via inhibition of intracellular ROS production. CME treatment inhibited hydrogen peroxide-induced apoptotic cell death and apoptotic nuclear condensation in HDFs. In addition, CME prevented hydrogen peroxide-induced SA-β-gal-positive cells suggesting CME could inhibit oxidative stress-induced premature senescence. Therefore, these results suggest that CME might have protective effects against oxidative stress-induced premature senescence via scavenging ROS.

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Section: Introductionmentioning

confidence: 99%

Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Park

Lee

et al. 2014

Nutrients

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“…The methods of hematoxylin and eosin (H&E) staining for histopathological observation [14], terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay (Merck, Darmstadt, Germany) for apoptotic cell detection, immunohistochemistry (IHC) [15] and statistical analysis [14] were described in our previous research reports. Immunohistochemical reactions targeting cleaved caspase-3 for apoptotic cells, proliferating cell nuclear antigen (PCNA) for proliferative cells, catalase and brain derived neurotrophic factor (BDNF) were performed with anti-cleaved caspase-3 (Cell Signaling, Massachusetts, USA), anti-PCNA (Merck, Darmstadt, Germany), anti-catalase (Abcam, Cambridge, UK) and anti-BDNF (Life Technologies, California, USA) antibodies respectively.…”

Section: Methodsmentioning

confidence: 99%

Penetrating Ocular Trauma in a Goldfish Model after Chloramphenicol or Traditional Medicine Angong Niuhuang Pill Treatment: An Analysis of Retinal Responses after 7 Days

Cheng¹,

Wai²,

Chow³

et al. 2022

OJOph

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Purpose: While there were numerous clinical examples of ocular damage, the histopathology of retinal responses was poorly characterized, and animal model research was limited. The consequences of retinal lesions with traditional medicine treatment were mostly unknown. In this work, goldfish was employed as a model for penetrating injury of the eyes to study the ocular trauma with antibiotic and traditional medicine treatments. Materials and Methods: The penetration of the eyes was performed at 2mm above the midline of the limbus in the superior quadrant with an 18-gauge sterile needle, all the way to the retina but avoiding the lens while the animals were anaesthetized in water containing 100 mg/L ethyl 3-aminobenzoate methanesulfonate (MS-222). The animals were divided into three groups and received treatments of saline, chloramphenicol, and Angong Niuhuang pill (Angong) eyedrops twice a day respectively. Angong after seven days, the animals were sacrificed. Immunohistochemical evaluation of proliferative cell nuclear antigen (PCNA), brain-derived neurotrophic factor (BDNF), catalase, and cleaved caspase-3, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) for apoptotic cells were performed on the fish's superior quadrants of the retinae. The whole experiment was repeated two times. Result: It was evident that both the retinae treated with chloramphenicol and Angong had fewer apoptotic cells and more proliferative cells, particularly in the cases of the Angong treatment. BDNF was in the inner nuclear layer and ganglion cell layer of all groups. In the chloramphenicol and Angong groups, some cells in

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“…In a report by Lam et al. [ 51 ], the incision wound model was used and performed on ICR mice, with 0.5 mg of A. bisporus extract mixed with 100 IU of vitamin E that was applied twice daily for 6 days. Immunochemistry, TUNEL assay, and Western blotting techniques were adopted to reveal an increased expression of epidermal growth factor (EGF) and proliferative cell nuclear antigen (PCNA), but the expression of TGF-β was not significant and few immune factor CD4 T cells were observed.…”

Section: The Utilization Of Macrofungi For Wound Healingmentioning

confidence: 99%

The Wound Healing Potential of Lignosus rhinocerus and Other Ethno-myco Wound Healing Agents

et al. 2023

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Wound care has become increasingly important over the years. Various synthetic products for wound care treatment have been reported to cause toxic side effects and therefore natural products are in significant demand as they have minimal side effects. The presence of bioactive compounds in medicinal mushrooms contributes to various biological activities which assist in the early inflammatory phase, keratinocyte proliferation, and its migration enhancement which are pertinent to wound rehabilitation. Lignosus rhinocerus (tiger milk mushroom) can reduce the inflammation phase in wound healing by fighting off bacterial infection and modulating pro-inflammatory cytokines expression in the early stage to avoid prolonged inflammation and tissue damage. The antibacterial, immunomodulating, and anti-inflammatory activities exhibited by most macrofungi play a key role in enhancing wound healing. Several antibacterial and antifungal compounds sourced from traditional botanicals/products may prevent further complications and reoccurrence of injury to a wounded site. Scientific studies are actively underway to ascertain the potential use of macrofungi as a wound healing agent.

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Extract of white button mushroom affects skin healing and angiogenesis

Cited by 6 publications

References 30 publications

Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Penetrating Ocular Trauma in a Goldfish Model after Chloramphenicol or Traditional Medicine Angong Niuhuang Pill Treatment: An Analysis of Retinal Responses after 7 Days

The Wound Healing Potential of Lignosus rhinocerus and Other Ethno-myco Wound Healing Agents

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